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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Chloride intracellular channel 2

CLIC2, XAP121, chloride intracellular channel 2
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family; the protein is detected in fetal liver and adult skeletal muscle tissue. This gene maps to the candidate region on chromosome X for incontinentia pigmenti. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, CLIC1, GST, RyR2, Actin
Papers on CLIC2
A Fluorescent Live Imaging Screening Assay Based on Translocation Criteria Identifies Novel Cytoplasmic Proteins Implicated in G Protein-coupled Receptor Signaling Pathways.
New
Galzi et al., Illkirch-Graffenstaden, France. In Mol Cell Proteomics, May 2015
The Chloride intracellular Channel protein, CLIC2, translocated from actin-enriched plasma membrane bundles to cell-cell junctions upon activation of NK2 receptors.
Clinical characterization of int22h1/int22h2-mediated Xq28 duplication/deletion: new cases and literature review.
Cheung et al., Houston, United States. In Bmc Med Genet, 2014
Increased dosage of CLIC2 may also contribute to the phenotype.
Xq28 duplication overlapping the int22h-1/int22h-2 region and including RAB39B and CLIC2 in a family with intellectual and developmental disability.
Lamb et al., Salt Lake City, United States. In Am J Med Genet A, 2014
We compare our clinical findings to patients with int22h-1/int22h-2-mediated duplications and discuss the potential pathogenicity of genes within the duplicated region, including those within the shared region of overlap, RAB39B and CLIC2.
XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing.
Mandel et al., Illkirch-Graffenstaden, France. In Am J Hum Genet, 2013
We also highlight 15 other genes (CCDC22, CLIC2, CNKSR2, FRMPD4, HCFC1, IGBP1, KIAA2022, KLF8, MAOA, NAA10, NLGN3, RPL10, SHROOM4, ZDHHC15, and ZNF261) for which replication studies are warranted.
The regulation of gene expression involved in TGF-β signaling by ZNF804A, a risk gene for schizophrenia.
Takeda et al., Suita, Japan. In Schizophr Res, 2013
We found that ZNF804A-overexpression up-regulated four genes (ANKRD1, INHBE, PIK3AP1, and DDIT3) and down-regulated three genes (CLIC2, MGAM, and BIRC3).
2D DIGE analysis of the bursa of Fabricius reveals characteristic proteome profiles for different stages of chicken B-cell development.
Härtle et al., München, Germany. In Proteomics, 2013
Strongest protein expression difference (10.8-fold) was observed for chloride intracellular channel 2. This protein was thus far not associated with B-cell biology but our data suggest an important function in bursa B-cell development.
Differential gene expression of cardiac ion channels in human dilated cardiomyopathy.
Rivera et al., Valencia, Spain. In Plos One, 2012
SCN2B was upregulated, while KCNJ5, KCNJ8, CLIC2, CLCN3, CACNB2, and CACNA1C were downregulated.
An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity.
Dulhunty et al., Greenwood, United States. In Hum Mol Genet, 2012
Chloride intracellular channel 2 (CLIC2) protein is a member of the glutathione transferase class of proteins.
Novel systemic lupus erythematosus autoantigens identified by human protein microarray technology.
Wu et al., Beijing, China. In Biochem Biophys Res Commun, 2012
We then selected CLIC2 for further verification by ELISA in an extended cohort including 110 SLE, 121 non-AD, 118 RA, 117 SSc, and 105 pSS patients.
A missense mutation in CLIC2 associated with intellectual disability is predicted by in silico modeling to affect protein stability and dynamics.
Alexov et al., United States. In Proteins, 2011
Large-scale next generation resequencing of X chromosome genes identified a missense mutation in the CLIC2 gene on Xq28 in a male with X-linked intellectual disability (XLID) and not found in healthy individuals.
Refinement of the X-linked nonsyndromic high-grade myopia locus MYP1 on Xq28 and exclusion of 13 known positional candidate genes by direct sequencing.
Radhakrishna et al., Omaha, United States. In Invest Ophthalmol Vis Sci, 2011
Mutation search in exons and splice junctions of candidate genes CTAG2, GAB3, MPP1, F8Bver, FUNDC2, VBP1, RAB39B, CLIC2, TMLHE, SYBL, IL9R, SPRY3, and CXYorf1 did not detect a pathogenic or predisposing variant.
Regulation of the cardiac muscle ryanodine receptor by glutathione transferases.
Review
Board et al., Canberra, Australia. In Drug Metab Rev, 2011
We discuss interactions between a nonenzymatic member of the GST structural family, the CLIC-2 (type 2 chloride intracellular channel) protein, which inhibits both RyR1 and RyR2.
Epigenetic investigation of variably X chromosome inactivated genes in monozygotic female twins discordant for primary biliary cirrhosis.
LaSalle et al., Davis, United States. In Epigenetics, 2011
Transcript levels of the 125 variable XCI status genes was determined by quantitative RT-PCR analysis and two genes (CLIC2 and PIN4) were identified as consistently downregulated in the affected twin of discordant pairs.
Interaction of Sedlin with PAM14.
Fan et al., Hefei, China. In J Cell Biochem, 2010
We have previously shown that Sedlin interacts with the intracellular chloride channel proteins CLIC1 and CLIC2 in the cytoplasm.
CLIC2-RyR1 interaction and structural characterization by cryo-electron microscopy.
Yin et al., Albany, United States. In J Mol Biol, 2009
Chloride intracellular channel 2 (CLIC2), a newly discovered small protein distantly related to the glutathione transferase (GST) structural family, is highly expressed in cardiac and skeletal muscle, although its physiological function in these tissues has not been established.
The crystal structure of human chloride intracellular channel protein 2: a disulfide bond with functional implications.
GeneRIF
Su et al., Beijing, China. In Proteins, 2008
crystal structure of soluble human CICL2 and implications for function
Structure of the Janus protein human CLIC2.
GeneRIF
Parker et al., Australia. In J Mol Biol, 2007
CLIC2 forms pH-dependent chloride channels in vitro with higher channel activity at low pH levels and that the channels are subject to redox regulation
Expression, purification, crystallization and preliminary X-ray diffraction analysis of chloride intracellular channel 2 (CLIC2).
GeneRIF
Parker et al., Australia. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2007
Human CLIC2 was crystallized in 2 different forms, in presence of GSSH. Form A displayed P2(1)2(1)2(1) symmetry, with unit-cell parameters a=44.0, b=74.7, c=79.8 A. Form B displayed P2(1) symmetry, with unit-cell parameters a=36.0, b=66.9, c=44.1 A.
CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels.
GeneRIF
Dulhunty et al., Canberra, Australia. In Int J Biochem Cell Biol, 2004
CLIC2 inhibited cardiac ryanodine receptor Ca2+ release channels in lipid bilayers when added to the cytoplasmic side of the channels and inhibited Ca2+ release from cardiac sarcoplasmic reticulum vesicles
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