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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Chloride intracellular channel 1

CLIC1, G-6, chloride intracellular channel 1, NCC27
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, fibrillin-1, ACID, V1a, H1
Papers on CLIC1
Molecular identity of cardiac mitochondrial chloride intracellular channel proteins.
Singh et al., Philadelphia, United States. In Mitochondrion, Feb 2016
In this study, we report the presence of unique dimorphic Chloride Intracellular Channel proteins (CLICs) namely CLIC1, CLIC4 and CLIC5 as abundant CLICs in the rodent heart.
Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo.
Ahnfelt-Rønne et al., Denmark. In Mol Endocrinol, Jan 2016
These included several proteins, not previously associated with pregnancy-induced islet expansion, such as CLIC1, STMN1, MCM6, PPIB, NEDD4, and HLTF.
Characterization and sub-cellular localization of GalNAc-binding proteins isolated from human hepatic stellate cells.
Li et al., Xi'an, China. In Biochem Biophys Res Commun, Jan 2016
The western blotting showed the expression levels of COX17, and PRMT1 were significantly up-regulated, while, the expression level of CLIC1(B5) was down-regulated in the activated HSCs and liver cirrhosis tissues.
Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway.
Zhang et al., Laiwu, China. In Mol Med Report, Dec 2015
Chloride intracellular channel 1 (CLIC1) has been demonstrated to be overexpressed in gastric cancer, and elevated CLIC1 expression levels are markedly associated with the processes of tumor cell migration and invasion.
MAPRE1 as a Plasma Biomarker for Early-Stage Colorectal Cancer and Adenomas.
Hanash et al., Houston, United States. In Cancer Prev Res (phila), Nov 2015
Three other biomarkers (AK1, CLIC1, and SOD1) were significantly increased in both adenoma and early colorectal cancer patient plasma samples and in plasma from colorectal cancer mouse models at preclinical stages compared with controls.
Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth.
Pelicci et al., Milano, Italy. In Oncotarget, Nov 2015
Recently we have demonstrated that Chloride Intracellular Channel-1 (CLIC1) is overexpressed in GBM compared to normal tissues, with highest expression in patients with poor prognosis.
Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets.
Mazzanti et al., Milano, Italy. In Biochim Biophys Acta, Oct 2015
In light of this, a new protein family, the chloride intracellular channels (CLICs), could be a promising class of therapeutic targets for its intrinsic individualities: CLIC1 and CLIC4, in particular, not only are overexpressed in specific tumor types or their corresponding stroma but also change localization and function from hydrophilic cytosolic to integral transmembrane proteins as active ionic channels or signal transducers during cell cycle progression in certain cases.
CLIC1 a novel biomarker of intraperitoneal metastasis in serous epithelial ovarian cancer.
Lou et al., Harbin, China. In Tumour Biol, Jun 2015
Here, we found that the expression of chloride intracellular channel 1 (CLIC1) is highly correlative with intraperitoneal metastasis.
Chloride intracellular channel 1 (CLIC1) is activated and functions as an oncogene in pancreatic cancer.
Gu et al., Shanghai, China. In Med Oncol, Jun 2015
Chloride intracellular channel 1 (CLIC1), a newly discovered member of the chloride channel protein family, has been implicated in multiple human cancers.
Reversible redox modifications in the microglial proteome challenged by beta amyloid.
Schininà et al., Roma, Italy. In Mol Biosyst, Jun 2015
Moreover, the redox modulation we observed on chloride intracellular channel protein 1 (CLIC1) strengthens the structural and functional relationship between the oxidative stress and the metamorphic transition of this protein from a soluble form to an integral membrane form.
Identification of prognosis-related proteins in gingival squamous cell carcinoma by twodimensional gel electrophoresis and mass spectrometry-based proteomics.
Giudice et al., In Ann Ital Chir, 2014
Among the differentially expressed proteins, we focused our attention on Chloride intracellular channel 1 (CLIC1).
Actin directly interacts with different membrane channel proteins and influences channel activities: AQP2 as a model.
Noda et al., Tokyo, Japan. In Biochim Biophys Acta, 2014
The 10 membrane channel proteins covered in this review are aquaporin 2 (AQP2), cystic fibrosis transmembrane conductance regulator (CFTR), ClC2, short form of ClC3 (sClC3), chloride intracellular channel 1 (CLIC1), chloride intracellular channel 5 (CLIC5), epithelial sodium channel (ENaC), large-conductance calcium-activated potassium channel (Maxi-K), transient receptor potential vanilloid 4 (TRPV4), and voltage-dependent anion channel (VDAC), with particular attention to AQP2.
Function of chloride intracellular channel 1 in gastric cancer cells.
Li et al., Nanning, China. In World J Gastroenterol, 2012
High CLIC1 expression can efficiently inhibit proliferation and enhance apoptosis, migration and invasion of gastric cancer cells in vitro.
Regulation of colon cancer cell migration and invasion by CLIC1-mediated RVD.
Xu et al., Anqing, China. In Mol Cell Biochem, 2012
CLIC1 regulates the migration and invasion of colon cancer cells.
PA28β regulates cell invasion of gastric cancer via modulating the expression of chloride intracellular channel 1.
Lin et al., Fuzhou, China. In J Cell Biochem, 2012
knockdown of PA28beta could enhance tumor invasion and metastasis, at least in part, through up-regulation of CLIC1 in gastric adenocarcinoma
Chloride intracellular channel 1 is an important factor in the lymphatic metastasis of hepatocarcinoma.
Tang et al., Dalian, China. In Biomed Pharmacother, 2012
The down-regulation of CLIC1 enhanced proliferative activity.
Role of individual histidines in the pH-dependent global stability of human chloride intracellular channel 1.
Dirr et al., Johannesburg, South Africa. In Biochemistry, 2012
Both histidine (His)74 and His185 are involved in triggering pH changes to the conformational stability of wild-type CLIC1 via their protonation, which stabilizes the intermediate state.
Ion channels on microglia: therapeutic targets for neuroprotection.
Skaper, Padova, Italy. In Cns Neurol Disord Drug Targets, 2011
A second example can be found in the chloride intracellular channel 1 (CLIC1), whose expression is related to macrophage activation, undergoes translocation from the cytosol to the plasma membrane (activation) of microglia exposed to amyloid β-peptide, and participates in amyloid β-peptide-induced neurotoxicity through the generation of reactive oxygen species.
Chloride intracellular channel 1 (CLIC1): Sensor and effector during oxidative stress.
Mazzanti et al., Milano, Italy. In Febs Lett, 2010
In this review, we consider the role of the intracellular chloride channel 1 (CLIC1) in microglial cells during oxidative stress.
The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins?
Curmi et al., Sydney, Australia. In Febs Lett, 2010
Chloride intracellular channel proteins (CLICs) are distinct from most ion channels in that they have both soluble and integral membrane forms.
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