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Cleavage and polyadenylation specific factor 4

cleavage and polyadenylation specificity factor
human homolog is an RNA binding protein involved in 3 end cleavage and polyadenylation of pre-mRNAs [RGD, Feb 2006] (from NCBI)
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Top mentioned proteins: CPSF, POLYMERASE, CAN, ACID, NS1
Papers on cleavage and polyadenylation specificity factor
Global analysis of CPSF2-mediated alternative splicing: Integration of global iCLIP and transcriptome profiling data.
New
Green et al., United States. In Genom Data, Dec 2015
Using a genome-wide RNA interference screening strategy, we identified cleavage and polyadenylation specificity factor (CPSF) and symplekin (SYMPK) as cofactors of the well-known splicing regulator RBFOX2.
The Y3** ncRNA promotes the 3' end processing of histone mRNAs.
New
Hüttelmaier et al., Halle, Germany. In Genes Dev, Nov 2015
We demonstrate that the Y3/Y3** noncoding RNAs (ncRNAs) bind to the CPSF (cleavage and polyadenylation specificity factor) and that Y3** associates with the 3' untranslated region (UTR) of histone pre-mRNAs.
Global Promotion of Alternative Internal Exon Usage by mRNA 3' End Formation Factors.
New
Green et al., Worcester, United States. In Mol Cell, Jul 2015
Unexpectedly, we find that two mRNA 3' end formation factors, cleavage and polyadenylation specificity factor (CPSF) and SYMPK, are RBFOX2 cofactors for both inclusion and exclusion of internal exons.
Characterization of plant polyadenylation complexes by using tandem affinity purification.
Li et al., Nanjing, China. In Methods Mol Biol, 2014
Based on homology analyses, Arabidopsis cleavage and polyadenylation specificity factor (AtCPSF) complex should play a critical role in pre-mRNA 3' end processing.
A model for cofactor use during HIV-1 reverse transcription and nuclear entry.
Review
Towers et al., London, United Kingdom. In Curr Opin Virol, 2014
We present a model that may explain how the capsid protein has a fundamental role in the early part of the viral lifecycle by utilising cyclophilin A (CypA), cleavage and polyadenylation specificity factor-6 (CPSF6), Nup358 and TNPO3 to orchestrate a coordinated process of DNA synthesis, capsid uncoating and integration targeting that evades innate responses and promotes integration into preferred areas of chromatin.
Integration of developmental and environmental signals via a polyadenylation factor in Arabidopsis.
Li et al., Xiamen, China. In Plos One, 2013
Previously, it was found that the 30 kD subunit of Arabidopsis cleavage and polyadenylation specificity factor (AtCPSF30) is a calmodulin-regulated RNA-binding protein.
HIV-1 evades innate immune recognition through specific cofactor recruitment.
Impact
Towers et al., London, United Kingdom. In Nature, 2013
Here we show that HIV-1 capsid mutants N74D and P90A, which are impaired for interaction with cofactors cleavage and polyadenylation specificity factor subunit 6 (CPSF6) and cyclophilins (Nup358 and CypA), respectively, cannot replicate in primary human monocyte-derived macrophages because they trigger innate sensors leading to nuclear translocation of NF-κB and IRF3, the production of soluble type 1 IFN and induction of an antiviral state.
The influenza virus NS1 protein as a therapeutic target.
Review
Engel, Charlottesville, United States. In Antiviral Res, 2013
Cellular RNA processing is also targeted by NS1, through recognition of cleavage and polyadenylation specificity factor 30 (CPSF30), leading to inhibition of IFN-β mRNA processing as well as that of other cellular mRNAs.
Structural biology of poly(A) site definition.
Review
Doublié et al., Burlington, United States. In Wiley Interdiscip Rev Rna, 2011
In mammalian cells, three well-studied sequence elements, UGUA, AAUAAA, and GU-rich, are recognized by three multisubunit factors: cleavage factor I(m) (CFI(m) ), cleavage and polyadenylation specificity factor (CPSF), and cleavage stimulation factor (CstF), respectively.
The hunt for the 3' endonuclease.
Review
Dominski, Chapel Hill, United States. In Wiley Interdiscip Rev Rna, 2010
Subsequent experimental studies supported the notion that CPSF-73 does function as the endonuclease in the formation of polyadenylated mRNAs, but some controversy still remains as a different cleavage and polyadenylation specificity factor (CPSF) subunit, CPSF-30, displays an endonuclease activity in vitro while recombinant CPSF-73 is inactive.
Translational control by cytoplasmic polyadenylation in Xenopus oocytes.
Review
de Moor et al., Nottingham, United Kingdom. In Biochim Biophys Acta, 2008
The cytoplasmic polyadenylation machinery such as CPEB, the subunits of cleavage and polyadenylation specificity factor (CPSF), symplekin, Gld-2 and poly(A) polymerase (PAP).
Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease.
Impact
Tong et al., New York City, United States. In Nature, 2007
Recent analyses indicated that the 73-kDa subunit of cleavage and polyadenylation specificity factor (CPSF-73) might be the endonuclease for this and related reactions, although no direct data confirmed this.
Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.
Impact
Shiekhattar et al., Philadelphia, United States. In Cell, 2005
Two of the Integrator subunits display similarities to the subunits of the cleavage and polyadenylation specificity factor (CPSF) complex.
A candidate prostate cancer susceptibility gene at chromosome 17p.
Impact
Cannon-Albright et al., Salt Lake City, United States. In Nat Genet, 2001
The gene product bears amino acid sequence similarity to two better understood protein families, namely the PSO2 (SNM1) DNA interstrand crosslink repair proteins and the 73-kD subunit of mRNA 3' end cleavage and polyadenylation specificity factor (CPSF73).
Dependence of yeast pre-mRNA 3'-end processing on CFT1: a sequence homolog of the mammalian AAUAAA binding factor.
Impact
Domdey et al., München, Germany. In Science, 1996
A CFII component, designated CFT1 (cleavage factor two) was identified by its sequence similarity to the AAUAAA-binding subunit of the mammalian cleavage and polyadenylation specificity factor (CPSF), even though the AAUAAA signal sequence appears to play no role in yeast pre-mRNA 3' processing.
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