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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa

CLE, EIF2B5, CACH, cytosolic acetyl-CoA hydrolase
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, eIF2B, V1a
Papers on CLE
Urea and lipid extraction treatment effects on δ(15) N and δ(13) C values in pelagic sharks.
New
Dai et al., Shanghai, China. In Rapid Commun Mass Spectrom, Feb 2016
Mathematical normalization of urea and lipid-extracted δ(15) NLE+DW and δ(13) CLE+DW values using the lipid-extracted δ(15) NLE and δ(13) CLE data were established for all pelagic shark species.
No evidence for a role of Ile587Val polymorphism of EIF2B5 gene in multiple sclerosis in Kashmir Valley of India.
New
Haq et al., Srīnagar, India. In J Neurol Sci, Jan 2016
Moreover, a recent study has implicated EIF2B5 Ile587Val (rs843358) polymorphism as a susceptibility factor for MS.
The TDIF signaling network.
Review
New
Fukuda et al., Tokyo, Japan. In Curr Opin Plant Biol, Dec 2015
CLAVATA3 (CLV3)/EMBRYO SURROUNDING REGION-related (CLE) peptides are crucial intercellular signaling molecules that control plant meristem maintenance.
Dual RNA-seq reveals Meloidogyne graminicola transcriptome and candidate effectors during the interaction with rice plants.
New
Fernandez et al., Montpellier, France. In Mol Plant Pathol, Dec 2015
Combined to expression data, this pipeline enabled identification of 15 putative effector genes, including two homologs of well-characterized effectors from cyst nematodes (CLE-like and VAP1), and a metallothionein.
Tumor neoangiogenesis detection by confocal laser endomicroscopy and anti-CD105 antibody: Pilot study.
New
Gruionu et al., Craiova, Romania. In World J Gastrointest Oncol, Dec 2015
AIM: To evaluate neoangiogenesis in patients with colon cancer by two fluorescently labeled antibodies on fresh biopsy samples imaged with confocal laser endomicroscopy (CLE).
CLE peptide signaling in plants - the power of moving around.
Review
New
Nilsson et al., Umeå, Sweden. In Physiol Plant, Sep 2015
The CLAVATA3 (CLV3)/EMBRYO SURROUNDING REGION (ESR)-RELATED (CLE) gene family encodes small secreted peptide ligands in plants.
The role of cytokines in the pathogenesis of cutaneous lupus erythematosus.
Review
New
Werth et al., Philadelphia, United States. In Cytokine, Jun 2015
Cutaneous lupus erythematosus (CLE) is an inflammatory disease with a broad range of cutaneous manifestations that may be accompanied by systemic symptoms.
Dynamics of long-distance signaling via plant vascular tissues.
Review
Okamoto et al., Nagoya, Japan. In Front Plant Sci, 2014
Recent studies have revealed that CLE and CEP peptides secreted in the roots are transported to above ground via the xylem in response to plant-microbe interaction and soil nitrogen starvation, respectively.
[Consecutive formation of the functions of high-, low-density and very-low-density lipoproteins during phylogenesis. Unique algorithm of the effects of lipid-lowering drugs].
Review
Aripovsky et al., In Ter Arkh, 2014
Active uptake of polyenoic FA (PUFA) required the following: a) PUFA re-esterified from polar phospholipids into nonpolar cholesteryl polyesters (poly-CLE), b) a novel protein, cholesteryl ester transfer protein (CETP), initiated poly-CLE transformation from HDL to LDL.
CLE Peptide Signaling and Crosstalk with Phytohormones and Environmental Stimuli.
Wu et al., Xi'an, China. In Front Plant Sci, 2014
The CLE (CLAVATA3/Endosperm surrounding region-related) peptide family is one of the best-studied secreted peptide families in plants.
A Role of TDIF Peptide Signaling in Vascular Cell Differentiation is Conserved Among Euphyllophytes.
Bowman et al., Melbourne, Australia. In Front Plant Sci, 2014
During Arabidopsis thaliana vascular development, a CLE (CLAVATA3/EMBRYO SURROUNDING REGION-related) family peptide hormone, TDIF (tracheary element differentiation inhibitory factor), regulates procambial cell fate by its inhibitory activity on xylem differentiation.
Cellular human CLE/C14orf166 protein interacts with influenza virus polymerase and is required for viral replication.
GeneRIF
Nieto et al., Madrid, Spain. In J Virol, 2011
Silencing of CLE causes reduction of influenza A virus polymerase activity, viral RNA transcription and replication, virus titer, and viral particle production.
Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein.
GeneRIF
Wang et al., Zhengzhou, China. In J Proteome Res, 2011
spatial interactions of hnRNPH1, NF45, and C14orf166 with HCVc174 likely modulate HCV or cellular functions during acute and chronic HCV infection
[Vanishing white matter disease: a stress-related leukodystrophy].
GeneRIF
Weber et al., In Nervenarzt, 2011
Also a mutation c.1913G>A[p.Arg638 His] in exon 14 of the EIF2B5-Gens as single nucleotide polymorphism.
Functional analysis of recently identified mutations in eukaryotic translation initiation factor 2Bɛ (eIF2Bɛ) identified in Chinese patients with vanishing white matter disease.
GeneRIF
Jiang et al., Beijing, China. In J Hum Genet, 2011
Functional analysis of recently identified mutations in eukaryotic translation initiation factor 2Bepsilon (eIF2Bepsilon) identified in Chinese patients with vanishing white matter disease
Crystal structure of the C-terminal domain of the ɛ subunit of human translation initiation factor eIF2B.
GeneRIF
Gong et al., Beijing, China. In Protein Cell, 2010
crystal structure of the guanine nucleotide exchange factor for elf2
Arabidopsis CLV3 peptide directly binds CLV1 ectodomain.
Impact
Matsubayashi et al., Nagoya, Japan. In Science, 2008
The CLV1 ectodomain also interacts with the structurally related CLE peptides, with distinct affinities depending on the specific amino acid sequence.
Dodeca-CLE peptides as suppressors of plant stem cell differentiation.
Impact
Fukuda et al., Tokyo, Japan. In Science, 2006
A bioassay of single-cell transdifferentation demonstrates that a dodecapeptide with two hydroxyproline residues is the functional product of genes from the CLE family, which includes CLAVATA3 in Arabidopsis.
EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy.
Impact
GeneRIF
Pröschel et al., Rochester, United States. In Nat Med, 2005
mutations in EIF2b5 causes a specific reduction in the generation of GFAP+ astrocytes in vanishing white matter disease
Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter.
Impact
van der Knaap et al., Amsterdam, Netherlands. In Nat Genet, 2001
We have identified mutations in EIF2B5 and EIF2B2, encoding the epsilon- and beta-subunits of the translation initiation factor eIF2B and located on chromosomes 3q27 and 14q24, respectively, as causing VWM.
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