ClC-3 chloride channel functions as a mechanically sensitive channel in osteoblasts.
Xi'an, China. In Biochem Cell Biol, Dec 2015
Mechanical force also up-regulated the mRNA level of osteogenic markers such as alkaline phosphatase (Alp), bone sialoprotein (Bsp), and osteocalcin (Oc), which could be blocked or strengthened by Clcn3 siRNA or overexpressing, and Alp expression was more sensitive to the changes of ClC-3 level.
CLC-3 channels in cancer (review).
Changchun, China. In Oncol Rep, Feb 2015
CLC-3 is a member of the voltage-gated chloride channel superfamily and is expressed in many cancer cells.
Porosome in Cystic Fibrosis.
Detroit, United States. In Discoveries (craiova), 2014
Since CFTR is known to interact with the t-SNARE protein syntaxin-1A, and with the chloride channel CLC-3, which are also components of the porosome complex, the interactions between CFTR and the porosome complex in the mucin-secreting human airway epithelial cell line Calu-3 was hypothesized and tested.
Cl⁻ channels in smooth muscle cells.
In Pflugers Arch, 2014
Both "classic" and cGMP-dependent calcium (Ca2+)-activated (ClCa) channels and volume-sensitive Cl− channels are present, with TMEM16A/ANO1, bestrophins, and ClC-3, respectively, proposed as molecular candidates for these channels.
Cell cycle-dependent subcellular distribution of ClC-3 in HeLa cells.
Guangzhou, China. In Histochem Cell Biol, 2012
results reveal a cell cycle-dependent change of the subcellular distribution of ClC-3 and strongly suggest that ClC-3 has nucleocytoplasmic shuttling dynamics that may play key regulatory roles during different stages of the cell cycle in tumor cells.
Anion transport in heart.
Reno, United States. In Physiol Rev, 2000
I(Cl.Ca), and I(Cl.ir) (ClC-3, CLCA1, and ClC-2, respectively) have recently been identified and are presently being evaluated.
Molecular identification of a volume-regulated chloride channel.
Reno, United States. In Nature, 1997
Here we report that functional expression in NIH/3T3 cells of a cardiac clone of another member of the ClC family, ClC-3, results in a large basally active chloride conductance, which is strongly modulated by cell volume and exhibits many properties identical to those of ICl.vol in native cells.