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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Chloride channel 2

ClC-2, CLCN2
This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] (from NCBI)
Top mentioned proteins: ACID, ClC-3, Cystic Fibrosis Transmembrane Conductance Regulator, CAN, HAD
Papers on ClC-2
Opioid-induced constipation in chronic noncancer pain.
New
Weber, Boston, United States. In Curr Opin Endocrinol Diabetes Obes, Feb 2016
Lubiprostone, a bicyclical fatty acid acting via activation of intestinal chloride channel-2 (ClC-2), was also approved for OIC treatment in patients with noncancer pain.
Gating the glutamate gate of CLC-2 chloride channel by pore occupancy.
New
Arreola et al., San Luis Potosí, Mexico. In J Gen Physiol, Jan 2016
CLC-2 channels are dimeric double-barreled chloride channels that open in response to hyperpolarization.
A Novel Mechanism of pH Buffering in C. elegans Glia: Bicarbonate Transport via the Voltage-Gated ClC Cl- Channel CLH-1.
New
Bianchi et al., Miami, United States. In J Neurosci, Jan 2016
CLH-1 has homology and electrophysiological properties similar to the mammalian ClC-2 Cl(-) channel.
CLCN2-Related Leukoencephalopathy
Review
New
Abbink et al., Seattle, United States. In Unknown Journal, Dec 2015
CLINICAL CHARACTERISTICS: CLCN2-related leukoencephalopathy (CC2L) is characterized by nonspecific neurologic findings, mild visual impairment from chorioretinopathy or optic atrophy, male infertility, and characteristic findings on brain MRI.
ClC-2 regulation of intestinal barrier function: Translation of basic science to therapeutic target.
Review
New
Blikslager et al., Raleigh, United States. In Tissue Barriers, Oct 2015
The ClC-2 chloride channel is a member of the voltage-gated chloride channel family.
Regulatory-auxiliary subunits of CLC chloride channel-transport proteins.
Review
New
Estévez et al., Barcelona, Spain. In J Physiol, Oct 2015
The CLC family of chloride channels and transporters is composed by nine members, but only three of them, ClC-Ka/b, ClC-7 and ClC-2, have been found so far associated with auxiliary subunits.
Congestive Heart Failure Leads to Prolongation of the PR Interval and Atrioventricular Junction Enlargement and Ion Channel Remodelling in the Rabbit.
Boyett et al., Manchester, United Kingdom. In Plos One, 2014
mRNA abundance for ANP, CLCN2 and Navβ1 was increased with heart failure; Nav1.1 was increased in the inferior nodal extension/compact node area.
Identification of Novel Epigenetic Markers of Prostate Cancer by NotI-Microarray Analysis.
Kashuba et al., Moscow, Russia. In Dis Markers, 2014
Based on these data, we proposed the set of potential biomarkers for detection of prostate cancer and discrimination between prostate tumors with different malignancy and aggressiveness: BHLHE40, FOXP1, LOC285205, ITGA9, CTDSPL, FGF12, LOC440944/SETD5, VHL, CLCN2, OSBPL10/ZNF860, LMCD1, FAM19A4, CAND2, MAP4, KY, and LRRC58.
ClC-1 chloride channels: state-of-the-art research and future challenges.
Review
Camerino et al., Bari, Italy. In Front Cell Neurosci, 2014
The expression of ClC-1 in other tissues such as in brain and heart and the possible assembly of ClC-1/ClC-2 heterodimers further expand the physiological properties of ClC-1 and its involvement in diseases.
MLC1 protein: a likely link between leukodystrophies and brain channelopathies.
Review
Ambrosini et al., Roma, Italy. In Front Cell Neurosci, 2014
Recently, the GlialCAM adhesion protein was found essential for the membrane expression and function of the chloride channel ClC-2 indicating MLC disease caused by mutation in GlialCAM as the first channelopathy among leukodystrophies.
Brain white matter oedema due to ClC-2 chloride channel deficiency: an observational analytical study.
Impact
van der Knaap et al., Paris, France. In Lancet Neurol, 2013
We found evidence that the CLCN2 mutations result in loss of function of ClC-2.
GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit.
GeneRIF
Estévez et al., Genova, Italy. In Neuron, 2012
This study demonistrated that the first auxiliary subunit of ClC-2 and suggests that ClC-2 may play a role in the pathology of MLC disease.
Severe defects in absorptive ion transport in distal colons of mice that lack ClC-2 channels.
GeneRIF
Melvin et al., Bethesda, United States. In Gastroenterology, 2012
ClC-2 channels are required for colonic electroneutral absorption of NaCl and KCl.
Chloride channel ClC-2 modulates tight junction barrier function via intracellular trafficking of occludin.
GeneRIF
Blikslager et al., Raleigh, United States. In Am J Physiol Cell Physiol, 2012
ClC-2 plays an important role in the modulation of tight junctions by influencing caveolar trafficking of tight junction protein occludin.
Distinct expression/function of potassium and chloride channels contributes to the diverse volume regulation in cortical astrocytes of GFAP/EGFP mice.
GeneRIF
Anderova et al., Praha, Czech Republic. In Plos One, 2011
The PCR data revealed the existence of two astrocytic subpopulations markedly differing in their gene expression levels for inwardly rectifying K+ channels (Kir4.1), K(2P) channels (TREK-1 and TWIK-1) and Cl- channels (ClC2).
Downregulation of ClC-2 by JAK2.
GeneRIF
Lang et al., Tübingen, Germany. In Cell Physiol Biochem, 2011
JAK2 down-regulates ClC-2 activity and thus counteracts Cl(-) exit, an effect which may impact on cell volume regulation
The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes.
Impact
Mindell et al., Bethesda, United States. In Nature, 2008
Several mammalian members of the CLC family have been characterized in detail; some (including ClC-0, ClC-1 and ClC-2) function as Cl--conducting ion channels, whereas others act as Cl-/H+antiporters (ClC-4 and ClC-5).
Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5.
Impact
Pusch et al., Genova, Italy. In Nature, 2005
ClC-0, ClC-2 and ClC-Ka proteins showed no significant proton transport.
Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies.
Impact
Heils et al., Bonn, Germany. In Nat Genet, 2003
Here we report a gene associated with the four most common IGE subtypes: childhood and juvenile absence epilepsy (CAE and JAE), juvenile myoclonic epilepsy (JME), and epilepsy with grand mal seizures on awakening (EGMA; ref. 8).
Anion transport in heart.
Review
Impact
Horowitz et al., Reno, United States. In Physiol Rev, 2000
I(Cl.Ca), and I(Cl.ir) (ClC-3, CLCA1, and ClC-2, respectively) have recently been identified and are presently being evaluated.
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