Opioid-induced constipation in chronic noncancer pain.
Boston, United States. In Curr Opin Endocrinol Diabetes Obes, Feb 2016
Lubiprostone, a bicyclical fatty acid acting via activation of intestinal chloride channel-2 (ClC-2), was also approved for OIC treatment in patients with noncancer pain.
Seattle, United States. In Unknown Journal, Dec 2015
CLINICAL CHARACTERISTICS: CLCN2-related leukoencephalopathy (CC2L) is characterized by nonspecific neurologic findings, mild visual impairment from chorioretinopathy or optic atrophy, male infertility, and characteristic findings on brain MRI.
Identification of Novel Epigenetic Markers of Prostate Cancer by NotI-Microarray Analysis.
Moscow, Russia. In Dis Markers, 2014
Based on these data, we proposed the set of potential biomarkers for detection of prostate cancer and discrimination between prostate tumors with different malignancy and aggressiveness: BHLHE40, FOXP1, LOC285205, ITGA9, CTDSPL, FGF12, LOC440944/SETD5, VHL, CLCN2, OSBPL10/ZNF860, LMCD1, FAM19A4, CAND2, MAP4, KY, and LRRC58.
Downregulation of ClC-2 by JAK2.
Tübingen, Germany. In Cell Physiol Biochem, 2011
JAK2 down-regulates ClC-2 activity and thus counteracts Cl(-) exit, an effect which may impact on cell volume regulation
Anion transport in heart.
Reno, United States. In Physiol Rev, 2000
I(Cl.Ca), and I(Cl.ir) (ClC-3, CLCA1, and ClC-2, respectively) have recently been identified and are presently being evaluated.