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Claudin 6

claudin-6, Cldn6
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is essential for blastocyst formation in preimplantation mouse embryos, and is invloved in and is crucial for the formation and maintenance of the epidermal permeability barrier. This gene is adjacent to another family member Cldn9 on chromosome 17. [provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: claudin-1, CAN, Occludin, CLDN9, HAD
Papers on claudin-6
Selection of a hepatitis C virus with altered entry factor requirements reveals a genetic interaction between the E1 glycoprotein and claudins.
Evans et al., New York City, United States. In Hepatology, Oct 2015
Whereas Jc1 H316N efficiently infected cells lacking CLDN1, such infection was blocked by an antibody targeting CLDN6, another member of the claudin family that is expressed in these cells.
Conditional pulmonary over-expression of Claudin 6(Cldn6) during embryogenesis delays lung morphogenesis.
Reynolds et al., Provo, United States. In Int J Dev Biol, Aug 2015
UNASSIGNED: Claudin 6 (Cldn6) is a tetraspanin protein expressed by barrier epithelial cells.
Xenopus Claudin-6 is required for embryonic pronephros morphogenesis and terminal differentiation.
Mao et al., Kunming, China. In Biochem Biophys Res Commun, Aug 2015
Here we studied the expression and functions of claudin-6 in Xenopus pronephros development.
Tight junction protein claudin-6 inhibits growth and induces the apoptosis of cervical carcinoma cells in vitro and in vivo.
Quan et al., Changchun, China. In Med Oncol, May 2015
Claudin-6, a member of claudin family integral membrane proteins, has recently been reported to be a tumor suppressor for breast cancer.
Claudin-6 and Occludin Natural Variants Found in a Patient Highly Exposed but Not Infected with Hepatitis C Virus (HCV) Do Not Confer HCV Resistance In Vitro.
Cocquerel et al., Lille, France. In Plos One, 2014
In a same case patient highly exposed but not infected by HCV, we previously identified one mutation in claudin-6 (CLDN6) and a rare variant in occludin (OCLN), two tight junction proteins involved in HCV entry into hepatocytes.
Low claudin-6 expression correlates with poor prognosis in patients with non-small cell lung cancer.
Shan et al., Ürümqi, China. In Onco Targets Ther, 2014
Abnormal claudin-6 expression has been observed for a variety of malignant solid tumors, but the expression of claudin-6 in non-small cell lung cancer (NSCLC) has not yet been characterized.
Expression of apoptosis signal-regulating kinase 1 is associated with tight junction protein claudin-6 in cervical carcinoma.
Quan et al., Changchun, China. In Int J Clin Exp Pathol, 2014
In our previous work, apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase (MAPK) kinase family has been proved to be associated with the pro-apoptosis effect of tight junction protein claudin-6 in breast cancer.
Changes in the phosphorylation of claudins during the course of experimental colitis.
Xia et al., Hefei, China. In Int J Clin Exp Pathol, 2014
In the present study, we found that the phosphorylated claudin-4 and claudin-7 contents were increased in experimental colitis at days 6 and 8, and colonic phosphorylated claudin-6 was found to be increased at day 4 and day 8. Colonic phosphorylated claudin-5 was found to be decreased at day 4 but increased at day 6.
Distinct claudin expression characterizes BRCA1-related breast cancer.
van der Groep et al., Utrecht, Netherlands. In Histopathology, 2014
In multivariate analysis, overexpression of claudin 3, 4, and 7 was mainly dependent on ER-status, whereas overexpression of claudin 6 and high membranous expression of claudin 1 were independent of other characteristics.
Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer.
Türeci et al., Uppsala, Sweden. In Int J Cancer, 2014
The objective of this study was to assess which fraction of patients with non-small-cell lung cancer (NSCLC) express CLDN6 and CLDN18 isoform 2 (CLDN18.2).
Claudin-6, -10d and -10e contribute to seawater acclimation in the euryhaline puffer fish Tetraodon nigroviridis.
Kelly et al., Toronto, Canada. In J Exp Biol, 2014
Expression profiles of claudin-6, -10d and -10e in the euryhaline teleost fish Tetraodon nigroviridis revealed claudin-6 in brain, eye, gill and skin tissue, while claudin-10d and -10e were found in brain, gill and skin only.
Genome wide expression analysis suggests perturbation of vascular homeostasis during high altitude pulmonary edema.
Sarkar et al., Delhi, India. In Plos One, 2013
Some notable genes within these pathways included MYLK; rho family members ARGEF11, ARHGAP24; cell adhesion molecules such as CLDN6, CLDN23, PXN and VCAM1 besides other signaling intermediates.
Developmental lung expression and transcriptional regulation of claudin-6 by TTF-1, Gata-6, and FoxA2.
Reynolds et al., Provo, United States. In Respir Res, 2013
However, the expression profile of Claudin-6 (Cldn6) in the developing lung has not been characterized.
Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma.
Sahin et al., Mainz, Germany. In Bmc Genomics, 2013
Proliferation and stem-cell markers, including Top2a, Birc5 (Survivin), Cldn6 and Mki67, are highly expressed while differentiation and top-crypt markers Muc2, Ms4a8a (MS4A8B) and Epcam are not.
Estrogen-responsive genes overlap with triiodothyronine-responsive genes in a breast carcinoma cell line.
Nogueira et al., Botucatu, Brazil. In Scientificworldjournal, 2013
Specifically, we found eight genes that were differentially expressed after treatment with both E₂ and T₃, including amphiregulin, fibulin 1, claudin 6, pericentriolar material 1, premature ovarian failure 1B, factor for adipocyte differentiation-104, sterile alpha motif domain containing 9, and likely ortholog of rat vacuole membrane protein 1 (fold change > 2.0, pFDR < 0.05).
Claudin-6 is a nonspecific marker for malignant rhabdoid and other pediatric tumors.
Judkins et al., Philadelphia, United States. In Am J Surg Pathol, 2012
CLDN6 is not a specific biomarker for atypical teratoid rhabdoid tumors as it is expressed in a variety of other pediatric CNS and soft tissue tumors.
Claudin-6, 7, or 9 overexpression in the human gastric adenocarcinoma cell line AGS increases its invasiveness, migration, and proliferation rate.
Rendon-Huerta et al., Mexico. In Cancer Invest, 2011
Increased expression of claudin-6, claudin-7, or claudin-9 is sufficient to enhance tumorigenic properties of a gastric adenocarcinoma cell line.
[Effects of stable up-regulation of tight junction protein claudin-6 upon biological phenotypes of breast cancer cell MCF-7].
Quan et al., Changchun, China. In Zhonghua Yi Xue Za Zhi, 2010
The up-regulation of claudin-6 expression in MCF-7 breast cancer cells suppresses their malignant phenotypes with a correlation with the restoration of tight junction integrity.
[Effects of 17β-estradiol on proliferation and migration of MCF-7 cell by regulating expression of claudin-6].
Li et al., Changchun, China. In Zhonghua Bing Li Xue Za Zhi, 2010
17beta-E2 might regulate the expression of claudin-6 and inhibit the proliferation and migration of MCF-7 cells.
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