Distinctive immunostaining of claudin-4 in spiradenomas.
Ankara, Turkey. In Ann Diagn Pathol, Nov 2015
Derangement in those important structures' physical integrity and/or function, which can be assessed by the presence or absence of several intercellular bridge proteins including claudin-4, E-cadherin, and β-catenin, was found to be related to several phenomena in the path to the neoplastic transformation.
Genes Regulating Epithelial Polarity Are Critical Suppressors of Esophageal Oncogenesis.
Xinxiang, China. In J Cancer, 2014
In particular, we reviewed the involvement of several critical genes, including Lkb1, claudin-4, claudin-7, Par3, Lgl1, E-cadherin, and the Scnn1 gene family.
Changes in the phosphorylation of claudins during the course of experimental colitis.
Hefei, China. In Int J Clin Exp Pathol, 2014
In the present study, we found that the phosphorylated claudin-4 and claudin-7 contents were increased in experimental colitis at days 6 and 8, and colonic phosphorylated claudin-6 was found to be increased at day 4 and day 8. Colonic phosphorylated claudin-5 was found to be decreased at day 4 but increased at day 6.
Claudin-4 as therapeutic target in cancer.
Marburg an der Lahn, Germany. In Arch Biochem Biophys, 2012
This review focus is on the role of claudin-4, an integral constituent of tight junctions, in the pathophysiology of epithelial malignancies with particular focus pancreatic cancer. [review]