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Claudin 4

claudin-4, CLDN4
This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Occludin, claudin-1, claudin-3, CAN, ZO-1
Papers on claudin-4
Giardia duodenalis induces para-cellular bacterial translocation and causes post-infectious visceral hypersensitivity.
Buret et al., Calgary, Canada. In Am J Physiol Gastrointest Liver Physiol, Feb 2016
Giardia-induced bacterial paracellular translocation in vitro correlated with the degradation of the tight junctional proteins occludin and claudin-4.
Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions.
Kuiken et al., Brisbane, Australia. In Eur Respir J, Feb 2016
Rather, barrier damage was associated with disruption of tight junctions amongst epithelial cells, and specifically with loss of tight junction protein claudin-4.Taken together, these data suggest that maintaining epithelial cell integrity is key in reducing pulmonary oedema during IAV infection.
Segmental Differences in Radiation-Induced Alterations of Tight Junction-Related Proteins in Non-Human Primate Jejunum, Ileum and Colon.
Hauer-Jensen et al., Québec, Canada. In Radiat Res, Jan 2016
NHPs were total-body irradiated with 6.7 and 7.4 Gy and intestines were procured at day 4, 7 and 12. Radiation exposure was found to induce significant increases in claudin-10 mRNA early (day 4) in all three gut segments and claudin-4 mRNA levels were repressed through day 12. TNF-alpha was highly induced in the jejunum and colon at early time points, but little induction was found in the ileum.
Tight Junction Ultrastructure Alterations in a Mouse Model of Enteral Nutrient Deprivation.
Teitelbaum et al., Ann Arbor, United States. In Dig Dis Sci, Jan 2016
These findings were correlated with the loss of TJ localization of claudin-4 and tricellulin, reduced expression of claudin-5 and claudin-8, and reduced ex vivo EBF.
Estrogen Enhances Esophageal Barrier Function by Potentiating Occludin Expression.
Shimosegawa et al., Sendai, Japan. In Dig Dis Sci, Jan 2016
The intercellular space of the epithelium was investigated with transmission electron microscopy and the expression of tight junction protein, occludin, claudin-1, and claudin-4, with immunoblotting.
Differential modulation of claudin 4 expression and myosin light chain phosphorylation by thyroid function in lung injury.
Omrani et al., Shīrāz, Iran. In Clin Respir J, Dec 2015
Therefore, we examined the effects of thyroid function on expression of phospho-MLC (pp-MLC) and claudin 4 (Clud4), key proteins involved in regulation of junctional tightness, in lung injury.
Distinctive immunostaining of claudin-4 in spiradenomas.
Özcan et al., Ankara, Turkey. In Ann Diagn Pathol, Nov 2015
Derangement in those important structures' physical integrity and/or function, which can be assessed by the presence or absence of several intercellular bridge proteins including claudin-4, E-cadherin, and β-catenin, was found to be related to several phenomena in the path to the neoplastic transformation.
Claudins: Gatekeepers of lung epithelial function.
Koval et al., Atlanta, United States. In Semin Cell Dev Biol, Jun 2015
Other claudins, notably claudin-4 and claudin-7, are more ubiquitously expressed throughout the respiratory epithelium.
Clostridium perfringens enterotoxin (CPE) and CPE-binding domain (c-CPE) for the detection and treatment of gynecologic cancers.
Santin et al., New Haven, United States. In Toxins (basel), Apr 2015
Clostridium perfringens enterotoxin (CPE) is a three-domain polypeptide, which binds to Claudin-3 and Claudin-4 with high affinity.
Tight junction, selective permeability, and related diseases.
Fromm et al., Berlin, Germany. In Semin Cell Dev Biol, 2014
Also some, but not all, barrier-forming claudins are charge-selective (claudin-4, -8, -14).
Genes Regulating Epithelial Polarity Are Critical Suppressors of Esophageal Oncogenesis.
Ji et al., Xinxiang, China. In J Cancer, 2014
In particular, we reviewed the involvement of several critical genes, including Lkb1, claudin-4, claudin-7, Par3, Lgl1, E-cadherin, and the Scnn1 gene family.
Changes in the phosphorylation of claudins during the course of experimental colitis.
Xia et al., Hefei, China. In Int J Clin Exp Pathol, 2014
In the present study, we found that the phosphorylated claudin-4 and claudin-7 contents were increased in experimental colitis at days 6 and 8, and colonic phosphorylated claudin-6 was found to be increased at day 4 and day 8. Colonic phosphorylated claudin-5 was found to be decreased at day 4 but increased at day 6.
Medullary thymic epithelial stem cells maintain a functional thymus to ensure lifelong central T cell tolerance.
Minato et al., Kyoto, Japan. In Immunity, 2014
We demonstrate that implantation of embryonic TECs expressing claudin-3 and claudin-4 (Cld3,4) in a medulla-defective thymic microenvironment restores medulla formation and suppresses multiorgan autoimmunity throughout life.
Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer.
Kojima et al., Sapporo, Japan. In World J Gastroenterol, 2014
Claudin-4 and -18 are overexpressed in human pancreatic cancer and its precursor lesions.
Claudin-4 as therapeutic target in cancer.
Michl et al., Marburg an der Lahn, Germany. In Arch Biochem Biophys, 2012
This review focus is on the role of claudin-4, an integral constituent of tight junctions, in the pathophysiology of epithelial malignancies with particular focus pancreatic cancer. [review]
Twist1 causes the transcriptional repression of claudin-4 with prognostic significance in esophageal cancer.
Kim et al., South Korea. In Biochem Biophys Res Commun, 2012
these results indicate that Twist1 induces the repression of claudin-4 expression during the epithelial-mesenchymal transition in esophageal carcinoma.
Apple extract induces increased epithelial resistance and claudin 4 expression in Caco-2 cells.
Mes et al., Wageningen, Netherlands. In J Sci Food Agric, 2012
Crude apple extract induces a higher paracellular resistance in differentiated Caco-2 cells, including claudin 4 expression.
Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudins.
Krause et al., Berlin, Germany. In J Biol Chem, 2012
Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudins
Distinct behavior of claudin-3 and -4 around lactation period in mammary alveolus in mice.
Kumura et al., Sapporo, Japan. In Histochem Cell Biol, 2011
Claudin-3 in the apical-most regions maintains the impermeable tight junctions during lactation, and claudin-4 contributes
Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin.
Minato et al., Kyoto, Japan. In Nat Immunol, 2007
Here we demonstrate that the tight-junction components claudin-3 and claudin-4 (Cld3,4) were 'preferentially' expressed in Aire(+) mTECs.
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