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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Claudin 3

claudin-3, CLDN3
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: claudin-4, Occludin, claudin-1, ZO-1, CAN
Papers on claudin-3
Development of a cell line from the American eel brain expressing endothelial cell properties.
Bols et al., Waterloo, Canada. In In Vitro Cell Dev Biol Anim, Jan 2016
The cells from late-passage cultures (>45) were polygonal, formed capillary-like structures (CLS) on Matrigel, and stained immunocytochemically for von Willebrand factor (vWF) and for three tight junction proteins, zonula occludens-1 (ZO-1), claudin 3, and claudin 5.
Long Noncoding RNA SPRY4-IT1 Regulates Intestinal Epithelial Barrier Function by Modulating the Expression Levels of Tight Junction Proteins.
Wang et al., Beijing, China. In Mol Biol Cell, Jan 2016
SPRY4-IT1 silencing led to dysfunction of the epithelial barrier in cultured cells by decreasing the stability of mRNAs encoding TJ proteins claudin-1, claudin-3, occludin, and JAM-1 and by repressing their translation.
GSK-3β inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats.
Wang et al., Wuhan, China. In Mol Neurobiol, Jan 2016
In addition, Western blot analysis showed that TWS119 increased the protein expression of β-catenin, claudin-3, and ZO-1 while suppressing the expression of GSK-3β.
BRCA Mutation-Related and Claudin-Low Breast Cancer: Blood Relatives or Stepsisters?
Szasz et al., Budapest, Hungary. In Pathobiology, Dec 2015
RESULTS: In the data sets, CLDN1 (ROC = 0.785, p < 0.001), CDH1 (ROC = 0.785, p < 0.001), CLDN7 (ROC = 0.723, p < 0.001), CLDN3 (ROC = 0.696, p = 0.020) and CLDN4 (ROC = 0.685, p = 0.027) were expressed at higher level in BRCAmut than BRCAwt tumor tissue.
Structural and Functional Changes in the Tight Junctions of Asymptomatic and Serology-negative First-degree Relatives of Patients With Celiac Disease.
Makharia et al., New Delhi, India. In J Clin Gastroenterol, Dec 2015
The ultrastructure of tight junctions using transmission electron microscopy, and the expression of key tight junction proteins (claudin-2, claudin-3, occludin, JAM-A, and ZO-1) and zonulin using real-time PCR and immunohistochemistry were assessed in anti-tTG Ab-negative, HLA-DQ2/-DQ8-positive FDRs having normal villi and in disease controls.
Neomycin and bacitracin reduce the intestinal permeability in mice and increase the expression of some tight-junction proteins.
Grasa et al., Zaragoza, Spain. In Rev Esp Enferm Dig, Nov 2015
Antibiotics increased the expression of zonula occludens 1 (ZO-1), junctional adhesion molecule A (JAM-A, and occludin in the ileum and ZO-1, claudin-3, and claudin-4 in the colon.
Clostridium perfringens enterotoxin (CPE) and CPE-binding domain (c-CPE) for the detection and treatment of gynecologic cancers.
Santin et al., New Haven, United States. In Toxins (basel), Apr 2015
Clostridium perfringens enterotoxin (CPE) is a three-domain polypeptide, which binds to Claudin-3 and Claudin-4 with high affinity.
Changes in the phosphorylation of claudins during the course of experimental colitis.
Xia et al., Hefei, China. In Int J Clin Exp Pathol, 2014
In T84 cells, phosphorylated claudin-3 was increased at 48 h but decreased at 72 h after lipopolysaccharide (LPS) treatment.
Medullary thymic epithelial stem cells maintain a functional thymus to ensure lifelong central T cell tolerance.
Minato et al., Kyoto, Japan. In Immunity, 2014
We demonstrate that implantation of embryonic TECs expressing claudin-3 and claudin-4 (Cld3,4) in a medulla-defective thymic microenvironment restores medulla formation and suppresses multiorgan autoimmunity throughout life.
Validation of proposed prostate cancer biomarkers with gene expression data: a long road to travel.
Pfeffer et al., Genova, Italy. In Cancer Metastasis Rev, 2014
The most interesting ones appeared to be claudin 3 (CLDN3) and alpha-methysacyl-CoA racemase highly expressed in prostate cancer and filamin C (FLNC) and keratin 5 with highest expression in normal prostate tissue.
Claudins overexpression in ovarian cancer: potential targets for Clostridium Perfringens Enterotoxin (CPE) based diagnosis and therapy.
Santin et al., New Haven, United States. In Int J Mol Sci, 2012
Claudin-3 and claudin-4 are the natural receptors for the Clostridium perfringens enterotoxin (CPE), a potent cytolytic toxin.
Claudin heterogeneity and control of lung tight junctions.
Koval, Atlanta, United States. In Annu Rev Physiol, 2012
Of the 14 claudins expressed by the alveolar epithelium, claudin-3, claudin-4, and claudin-18 are the most prominent; each confers unique properties to alveolar barrier function.
Regulation of paracellular transport in the distal nephron.
Hou, Saint Louis, United States. In Curr Opin Nephrol Hypertens, 2012
Histological studies have demonstrated the renal localization of claudin-3, claudin-4, claudin-7, and claudin-8 in the collecting duct.
Down-regulation of claudin-3 is associated with proliferative potential in early gastric cancers.
Miwa et al., Nishinomiya, Japan. In Dig Dis Sci, 2012
Dow-regulation of Claudin-3 is associated with the progression of early gastric adenocarcinomas.
Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudins.
Krause et al., Berlin, Germany. In J Biol Chem, 2012
Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudins
The tight junction protein claudin-3 shows conserved expression in the nephric duct and ureteric bud and promotes tubulogenesis in vitro.
Gupta et al., Montréal, Canada. In Am J Physiol Renal Physiol, 2011
Cldn3 may therefore promote tubule formation and expansion of the ureteric bud epithelium
Distinct behavior of claudin-3 and -4 around lactation period in mammary alveolus in mice.
Kumura et al., Sapporo, Japan. In Histochem Cell Biol, 2011
Claudin-3 in the apical-most regions maintains the impermeable tight junctions during lactation, and claudin-4 contributes to the permeability changes of them immediately after parturition and weaning.
Efficient inhibition of ovarian cancer by short hairpin RNA targeting claudin-3.
Zhao et al., Chengdu, China. In Oncol Rep, 2011
CLDN3 may have a role in ovarian cancer, and its inhibition by short hairpin RNA could be a treatment strategy.
A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition.
Fuxe et al., Stockholm, Sweden. In Nat Cell Biol, 2009
SNAIL1 and SMAD3/4 acted as co-repressors of CAR, occludin, claudin-3 and E-cadherin promoters in transfected cells.
Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin.
Minato et al., Kyoto, Japan. In Nat Immunol, 2007
Here we demonstrate that the tight-junction components claudin-3 and claudin-4 (Cld3,4) were 'preferentially' expressed in Aire(+) mTECs.
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