Claudin-1, -2, -3, -4, -5, and -7 in usual interstitial pneumonia and sarcoidosis
In International Journal of Molecular Sciences, 2008
... antibodies: Snail-1 (rabbit polyclonal, Ab 85931, 1:150, Abcam), E-cadherin (mouse monoclonal, M3612, 1:50, Dako) and claudin-1 (mouse monoclonal, sc-81796, 1:500, Santa Cruz Biotechnology, Inc.) by an indirect ...
Sirtuin and metabolic kidney disease.
Tokyo, Japan. In Kidney Int, Oct 2015
This further decreases expression of Sirt1 in glomerular podocytes and increases expression of a tight junction protein, claudin-1, which results in albuminuria.
The Genetics and Epigenetics of Atopic Dermatitis-Filaggrin and Other Polymorphisms.
Changsha, China. In Clin Rev Allergy Immunol, Oct 2015
Mutations in the human filaggrin gene (FLG) are the most significant and well-replicated genetic mutation associated with AD, and other mutations associated with epidermal barriers such as SPINK5, FLG-2, SPRR3, and CLDN1 have all been linked to AD. Gene variants may also contribute to the abnormal innate and adaptive responses found in AD, including mutations in PRRs and AMPs, TSLP and TSLPR, IL-1 family cytokines and receptors genes, vitamin D pathway genes, FCER1A, and Th2 and other cytokines genes.
Claudins and pathogenesis of viral infection.
Strasbourg, France. In Semin Cell Dev Biol, Jun 2015
Notable is the discovery of CLDN1 as an essential host factor for hepatitis C virus (HCV) entry, which led to detailed characterization of CLDN1 and its association with tetraspanin CD81 for the initiation of HCV infection.
Changes in the phosphorylation of claudins during the course of experimental colitis.
Hefei, China. In Int J Clin Exp Pathol, 2014
In the present study, we found that the phosphorylated claudin-4 and claudin-7 contents were increased in experimental colitis at days 6 and 8, and colonic phosphorylated claudin-6 was found to be increased at day 4 and day 8. Colonic phosphorylated claudin-5 was found to be decreased at day 4 but increased at day 6.
Genes Regulating Epithelial Polarity Are Critical Suppressors of Esophageal Oncogenesis.
Xinxiang, China. In J Cancer, 2014
In particular, we reviewed the involvement of several critical genes, including Lkb1, claudin-4, claudin-7, Par3, Lgl1, E-cadherin, and the Scnn1 gene family.
Claudin 1 in Breast Cancer: New Insights.
Winnipeg, Canada. In J Clin Med, 2014
Claudin 1 is a small transmembrane protein responsible for maintaining the barrier function that exists between epithelial cells.