Mechanisms of replication fork protection: a safeguard for genome stability.
London, United Kingdom. In Crit Rev Biochem Mol Biol, 2012
Both the ATR (ataxia telangiectasia and Rad3-related protein) kinase and the Replication pausing complex (RPC) components Tipin, Tim1 and Claspin play key roles in activating the intra S-phase checkpoint and in stabilizing the stalled replication forks.
Multiple functions of the S-phase checkpoint mediator.
Sanda, Japan. In Biosci Biotechnol Biochem, 2009
The S-phase checkpoint mediator protein Mrc1/Claspin mediates the checkpoint response to replication stress by facilitating phosphorylation of effector kinase by a sensor kinase.