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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Claspin

Claspin, CLSPN
The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: Chk1, CAN, Ubiquitin, Tipin, Rad17
Papers on Claspin
tRNA processing defects induce replication stress and Chk2-dependent disruption of piRNA transcription.
New
Huynh et al., Paris, France. In Embo J, Jan 2016
Here, we show that sterility is not due to a shortage of mature tRNAs, but that atrophied ovaries result from the activation of several DNA damage checkpoint proteins, including p53, Claspin, and Chk2.
Integrative network-based analysis of mRNA and microRNA expression in 1,25-dihydroxyvitamin D3-treated cancer cells.
New
Evelo et al., Maastricht, Netherlands. In Genes Nutr, Sep 2015
Six of the nine differentially expressed microRNAs target genes in the extended network, including CLSPN, an important checkpoint regulator in the cell cycle that was down-regulated, and FZD5, a receptor for Wnt proteins that was up-regulated.
And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress.
New
Zhu et al., Washington, D.C., United States. In Embo J, Sep 2015
And-1 is phosphorylated at T826 by ATR following replication stress, and this phosphorylation is required for And-1 to accumulate at the damage sites, where And-1 promotes the interaction between Claspin and Chk1, thereby stimulating efficient Chk1 activation by ATR.
SUMOylation of the C-terminal domain of DNA topoisomerase IIα regulates the centromeric localization of Claspin.
Azuma et al., Lawrence, United States. In Cell Cycle, 2014
We found that CTD SUMOylation promotes protein binding and that Claspin, a well-established cell cycle checkpoint mediator, is one of the SUMOylation-dependent binding proteins.
Identification of Promising Mutants Associated with Egg Production Traits Revealed by Genome-Wide Association Study.
Yang et al., Beijing, China. In Plos One, 2014
Analysis of GTF2A1 and CLSPN suggested that they influenced the function of ovary and uterus, and may be considered as relevant candidates.
The DNA-Binding Domain of S. pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers.
Dalgaard et al., Coventry, United Kingdom. In Plos One, 2014
Using a new genetic screen we identified Mrc1 (S. cerevisiae Mrc1/metazoan Claspin) as a replisome component involved in replication stalling.
DNA replication and homologous recombination factors: acting together to maintain genome stability.
Review
Costanzo et al., London, United Kingdom. In Chromosoma, 2013
Key constituents of the Replisome are the Cdc45-Mcm2-7-GINS helicase and the And1-Claspin-Tipin-Tim1 complex, which coordinate DNA unwinding with polymerase alpha-, delta-, and epsilon- dependent DNA polymerization.
Mechanisms of replication fork protection: a safeguard for genome stability.
Review
Costanzo et al., London, United Kingdom. In Crit Rev Biochem Mol Biol, 2012
Both the ATR (ataxia telangiectasia and Rad3-related protein) kinase and the Replication pausing complex (RPC) components Tipin, Tim1 and Claspin play key roles in activating the intra S-phase checkpoint and in stabilizing the stalled replication forks.
Functional relationship between Claspin and Rad17.
GeneRIF
Enomoto et al., Musashino, Japan. In Biochem Biophys Res Commun, 2011
the functions of Claspin and the functional relationship between Claspin and Rad17 were studied.
HERC2 Interacts with Claspin and regulates DNA origin firing and replication fork progression.
GeneRIF
Ohta et al., Kawasaki, Japan. In Cancer Res, 2011
In the presence of BRCA1, endogenous HERC2 interacts with Claspin, a protein essential for G(2)-M checkpoint activation and replication fork stability.
Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1).
GeneRIF
Sancar et al., Chapel Hill, United States. In J Biol Chem, 2011
Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1).
Phosphorylation of Claspin is triggered by the nucleocytoplasmic ratio at the Xenopus laevis midblastula transition.
GeneRIF
Sible et al., Blacksburg, United States. In Dev Biol, 2011
Claspin is phosphorylated at the midblastula transition at both DNA replication checkpoint-dependent and -independent sites.
Characterization of functional domains in human Claspin.
GeneRIF
Kemp et al., Chapel Hill, United States. In Cell Cycle, 2011
The multiple protein-DNA and protein-protein interactions is important for Claspin function during DNA replication and DNA replication checkpoint signaling.
Multiple functions of the S-phase checkpoint mediator.
Review
Tanaka, Sanda, Japan. In Biosci Biotechnol Biochem, 2009
The S-phase checkpoint mediator protein Mrc1/Claspin mediates the checkpoint response to replication stress by facilitating phosphorylation of effector kinase by a sensor kinase.
Dual functions of DNA replication forks in checkpoint signaling and PCNA ubiquitination.
Review
Zou et al., United States. In Cell Cycle, 2009
Surprisingly, the ubiquitination of PCNA is independent of ATR, but regulated by Claspin, a replication protein that mediates the activation of Chk1 by ATR.
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.
Impact
Pagano et al., New York City, United States. In Cell, 2008
This process induces the stabilization of Claspin, an activator of the DNA-damage checkpoint, and Wee1, an inhibitor of cell-cycle progression, and allows an efficient G2 checkpoint.
The mammalian DNA replication elongation checkpoint: implication of Chk1 and relationship with origin firing as determined by single DNA molecule and single cell analyses.
Review
Pommier et al., Bethesda, United States. In Cell Cycle, 2007
Normally in S phase, the progression of replication forks and their stability are regulated by the ATR-Claspin-Chk1 pathway.
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response.
Impact
Elledge et al., Boston, United States. In Cell, 2006
Our studies implicate DNA-damage-induced ubiquitination and deubiquitination as a major regulator of the DNA-damage response for Chk2, 53BP1, and a number of other proteins in the DNA-damage checkpoint pathway, including several mediators, such as Mdc1, Claspin, and TopBP1.
Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase.
Impact
Dunphy et al., Pasadena, United States. In Cell, 2004
The checkpoint mediator protein Claspin is essential for the ATR-dependent activation of Chk1 in Xenopus egg extracts containing aphidicolin-induced DNA replication blocks.
Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1.
Impact
Dunphy et al., Pasadena, United States. In Nat Cell Biol, 2003
The activation of Chk1 depends on both Claspin and the upstream regulatory kinase ATR.
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