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Cytoplasmic linker associated protein 2

associated with cytoplasmic linker proteins (CLIPs) that bind to the ends of growing microtubules; may be important for the regulation of microtubule dynamics [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Actin, EB1, sAST, V1a, CAN
Papers using CLASP2 antibodies
Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3β in migrating epithelial cells
Waterman-Storer Clare M. et al., In The Journal of Cell Biology, 2000
... CLASP2 tagged with multiple EGFPs was made by cloning an AgeI–MluI fragment of pEGFP-CLASP2 into XmaI–MluI-cut pEGFP-C1 (CLONTECH Laboratories, Inc.) ...
Papers on CLASP2
CLASP2 Has Two Distinct TOG Domains That Contribute Differently to Microtubule Dynamics.
Hayashi et al., Yokohama, Japan. In J Mol Biol, Aug 2015
Here, we report the crystal structures of the two TOG domains of CLASP2.
CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles.
Brenner et al., Rotterdam, Netherlands. In Mol Biol Cell, Apr 2015
We previously showed that microtubule (MT) capture by the plus end-tracking protein CLASP2 regulates AChR density at agrin-induced AChR clusters in cultured myotubes via PI3 kinase acting through GSK3β.
PAR3 and aPKC regulate Golgi organization through CLASP2 phosphorylation to generate cell polarity.
Kaibuchi et al., Nagoya, Japan. In Mol Biol Cell, Mar 2015
Here we demonstrate the functional cross-talk of the PAR complex with CLASP2, which is a microtubule plus-end-tracking protein and is involved in organizing the Golgi ribbon.
Electric signals regulate directional migration of ventral midbrain derived dopaminergic neural progenitor cells via Wnt/GSK3β signaling.
Song et al., Shenyang, China. In Exp Neurol, 2015
Pharmacologically inhibiting the canonical Wnt/GSK3β pathway significantly reduced the electrotactic response of NPCs(vm), which is associated with the down-regulation of GSK3β phosphorylation, β-catenin activation and CLASP2 expression.
Podosome-regulating kinesin KIF1C translocates to the cell periphery in a CLASP-dependent manner.
Kaverina et al., Nashville, United States. In J Cell Sci, 2015
Moreover, chimeric mitochondrially targeted CLASP2 recruits KIF1C, suggesting a transient CLASP-KIF1C association.
Acetylcholine receptor (AChR) clustering is regulated both by glycogen synthase kinase 3β (GSK3β)-dependent phosphorylation and the level of CLIP-associated protein 2 (CLASP2) mediating the capture of microtubule plus-ends.
Galjart et al., Rotterdam, Netherlands. In J Biol Chem, 2014
We have previously shown that microtubule (MT) capture by CLASP2, a MT plus-end-tracking protein (+TIP), increases the size and receptor density of AChR clusters at the NMJ through the delivery of AChRs and that this is regulated by a pathway involving neuronal agrin and several postsynaptic kinases, including GSK3.
CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover.
Wittmann et al., San Francisco, United States. In Nat Cell Biol, 2014
We report that clustering of microtubule-associated CLASP1 and CLASP2 proteins around FAs temporally correlates with FA turnover.
Activating hotspot L205R mutation in PRKACA and adrenal Cushing's syndrome.
Ning et al., Shanghai, China. In Science, 2014
Moreover, we discovered the recurrently mutated gene DOT1L in AIMAHs and CLASP2 in ADOs.
Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin.
Vanvactor et al., Heidelberg, Germany. In Cytoskeleton (hoboken), 2014
Using purified proteins, we find that Abl phosphorylation modulates direct binding between purified CLASP2 with both MTs and actin.
Microtubules CLASP to Adherens Junctions in epidermal progenitor cells.
Perez-Moreno et al., Madrid, Spain. In Bioarchitecture, 2014
Here, we comment on our recent findings showing that the MT plus-end binding protein CLASP2 interacts with the AJ component p120-catenin (p120) specifically in progenitor epidermal cells.
CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions.
Perez-Moreno et al., Madrid, Spain. In J Cell Biol, 2014
In this paper, we report that the MT plus end-binding protein CLASP2 localizes to adherens junctions (AJs) via direct interaction with p120-catenin (p120) in primary basal mouse keratinocytes.
A lack of association between polymorphisms of three positional candidate genes (CLASP2 , UBP1, and FBXL2) and canine disorder of sexual development (78,XX; SRY -negative).
Switonski et al., Poznań, Poland. In Sex Dev, 2013
Three positional candidate genes (CLASP2, UBP1, and FBXL2) were selected in silico in the search for polymorphisms in 7 testicular or ovotesticular XX DSD dogs, 8 XX DSD dogs of unknown cause (SRY-negative, with enlarged clitoris and unknown histology of gonads), and 29 normal female dogs as a control group.
Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2.
Sousa et al., In Bmc Biol, 2013
While several microtubule-interacting proteins are GSK3β substrates, phospho-mimetic collapsin response mediator protein 2 (T/D-CRMP-2) was sufficient to decrease microtubule growth speed and neurite outgrowth of conditioned neurons and of GSK3β-depleted neurons, prevailing over the effect of decreased levels of phosphorylated microtubule-associated protein 1B (MAP1B) and through a mechanism unrelated to decreased levels of phosphorylated cytoplasmic linker associated protein 2 (CLASP2).
Interstitial deletion of 3p22.3p22.2 encompassing ARPP21 and CLASP2 is a potential pathogenic factor for a syndromic form of intellectual disability: a co-morbidity model with additional copy number variations in a large family.
Zollino et al., Roma, Italy. In Am J Med Genet A, 2013
Among the transcribed genes residing in this interval, ARPP21 and CLASP2 are proposed as good candidate genes on the basis of their functional properties.
Agrin regulates CLASP2-mediated capture of microtubules at the neuromuscular junction synaptic membrane.
Brenner et al., Basel, Switzerland. In J Cell Biol, 2012
the cascade linking agrin to CLASP2-mediated microtubule capturing at the synaptic membrane is essential for the maintenance of a normal neuromuscular phenotype
Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).
Wittmann et al., San Francisco, United States. In J Biol Chem, 2012
Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).
CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment.
Maiato et al., Porto, Portugal. In Nat Cell Biol, 2012
Data show that CENP-E-mediated traction forces on misaligned chromosomes are responsible for the irreversible loss of spindle-pole integrity in CLASP1/2-depleted cells.
Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP.
Chang et al., Davis, United States. In Trends Cell Biol, 2011
Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP
FEZ1 interacts with CLASP2 and NEK1 through coiled-coil regions and their cellular colocalization suggests centrosomal functions and regulation by PKC.
Kobarg et al., Campinas, Brazil. In Mol Cell Biochem, 2010
Data report that NEK1 and CLASP2 colocalize with FEZ1 in a perinuclear region in mammalian cells, and observed that coiled-coil interactions occur between FEZ1/CLASP2 and FEZ1/NEK1 in vitro.
Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts.
Galjart et al., Rotterdam, Netherlands. In Cell, 2001
Antibody injections suggest that CLASP2 is required for the orientation of stabilized microtubules toward the leading edge.
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