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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 Nov 2016.

Latrophilin 1

CL1, CIRL, latrophilin
G protein-coupled receptor for alpha-Latrotoxin [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, ACID, Acetyl-CoA Carboxylase
Papers on CL1
A conserved island of BAG6/Scythe is related to ubiquitin domains and participates in short hydrophobicity recognition.
New
Kawahara et al., Tokyo, Japan. In Febs J, Jan 2016
In this study, we provide evidence that BAG6 physically interacts with the model defective protein substrate CL1 in a manner that depends directly on its short hydrophobicity.
Improved dual AAV vectors with reduced expression of truncated proteins are safe and effective in the retina of a mouse model of Stargardt disease.
New
Auricchio et al., Pozzuoli, Italy. In Hum Mol Genet, Jan 2016
Conversely, the inclusion of the CL1 degradation signal results in the selective degradation of truncated proteins from the 5'-half without affecting full-length protein production.
Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop.
New
Sorscher et al., United States. In J Biol Chem, Jan 2016
UNASSIGNED: In this study, we present data indicating a robust and specific domain interaction between the CFTR first cytosolic loop (CL1) and nucleotide binding domain 1 (NBD1) that allows ion transport to proceed in a regulated fashion.
Tangeretin Derivative, 5-Acetyloxy-6,7,8,4'-tetramethoxyflavone Induces G2/M arrest, Apoptosis and Autophagy in Human Non-Small Cell Lung Cancer Cells In vitro and In vivo.
New
Lin et al., T'ai-chung-shih, Taiwan. In Cancer Biol Ther, Dec 2015
In this study, we have further investigated the anticancer effects of 5-AcTMF on CL1-5 non-small cell lung cancer cells (NSCLC) both in vitro and in vivo and demonstrated that 5-AcTMF effectively inhibited cancer cell proliferation, induced G2/M-phase arrest associated with cdc2 and CDC25c and increased in the apoptotic cells associated with caspase activation, down regulation of Bcl-2, XIAP and Survivn, inducing release of cytochrome c into the cytosol and disruption of mitochondrial membrane potential.
Role of the teneurins, teneurin C-terminal associated peptides (TCAP) in reproduction: clinical perspectives.
New
Pavlović et al., In Horm Mol Biol Clin Investig, Dec 2015
The teneurin/TCAP protein forms an intercellular adhesive unit with its receptor, latrophilin, an Adhesion family G-protein coupled receptor.
Oriented Cell Division in the C. elegans Embryo Is Coordinated by G-Protein Signaling Dependent on the Adhesion GPCR LAT-1.
New
Prömel et al., Leipzig, Germany. In Plos Genet, Oct 2015
Here, we identify the signaling cascade of the C. elegans latrophilin homolog LAT-1, an essential player in the coordination of anterior-posterior spindle orientation during the fourth round of embryonic cell division.
Modulation of platelet and monocyte function by the chemokine fractalkine (CX3 CL1) in cardiovascular disease.
Review
New
Schäfer et al., Hannover, Germany. In Eur J Clin Invest, Jun 2015
BACKGROUND: The chemokine fractalkine, CX3CL1, bears unique features within the chemokine family: it exists in a membrane bound form acting as an adhesion molecule and surface receptor; however, when cleaved by ADAM 10, it functions as a soluble chemokine.
TAK1 inhibition-induced RIP1-dependent apoptosis in murine macrophages relies on constitutive TNF-α signaling and ROS production.
Lin et al., Taipei, Taiwan. In J Biomed Sci, 2014
RESULTS: TAK1 inhibitor (TAKI) can decrease the cell viability of murine bone marrow-derived macrophages (BMDM), RAW264.7 and BV-2 cells, but not dermal microvascular endothelial cells, normal human epidermal keratinocytes, THP-1 monocytes, human retinal pigment epithelial cells, microglia CHME3 cells, and some cancer cell lines (CL1.0,
Ancient interaction between the teneurin C-terminal associated peptides (TCAP) and latrophilin ligand-receptor coupling: a role in behavior.
Review
Lovejoy et al., Toronto, Canada. In Front Neurosci, 2014
They are highly expressed in the central nervous system, where they exert their effects, in part, by high-affinity binding to latrophilin (LPHN), a G-protein coupled receptor (GPCR) related to the adhesion and secretin GPCR families.
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
Review
Impact
Schiöth et al., Amsterdam, Netherlands. In Pharmacol Rev, 2014
The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98).
A review of ELTD1, a pro-angiogenic adhesion GPCR.
Review
Harris et al., Oxford, United Kingdom. In Biochem Soc Trans, 2014
Epidermal growth factor, latrophilin and seven-transmembrane domain-containing 1 (ELTD1), an orphan G-protein-coupled receptor (GPCR) belonging to the adhesion GPCR family, has recently been identified as a potential cancer biomarker and a novel regulator of angiogenesis.
Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 marker, a novel angiogenesis marker.
Review
Dricu et al., Craiova, Romania. In Onco Targets Ther, 2014
Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 on chromosome 1 (ELTD1), an orphan adhesion G-protein coupled receptor, was reported as a regulator of angiogenesis, also involved in cancer progression and development.
Fluorescence-Guided Probes of Aptamer-Targeted Gold Nanoparticles with Computed Tomography Imaging Accesses for in Vivo Tumor Resection.
Chen et al., Taipei, Taiwan. In Sci Rep, 2014
The fluorescent nanoparticle conjugates are applied as a molecular contrast agent to reveal the tumor location in CL1-5 tumor-bearing mice by CT imaging.
Genomic Diversity of Phages Infecting Probiotic Strains of Lactobacillus paracasei.
Moineau et al., Québec, Canada. In Appl Environ Microbiol, 2014
We analyzed the complete genome sequences of five L. paracasei temperate phages: CL1, CL2, iLp84, iLp1308, and iA2.
High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex.
GeneRIF
Südhof et al., Stanford, United States. In J Biol Chem, 2012
Neurexin 1 binding to latrophilin-1 produces a stable intercellular adhesion complex.
Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities.
GeneRIF
Ushkaryov et al., London, United Kingdom. In Proc Natl Acad Sci U S A, 2011
Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities.
Dissociation of the subunits of the calcium-independent receptor of alpha-latrotoxin as a result of two-step proteolysis.
GeneRIF
Petrenko et al., New York City, United States. In Biochemistry, 2009
further cleavage of CIRL by a second protease results in a soluble form of CIRL
Prohaptoglobin is proteolytically cleaved in the endoplasmic reticulum by the complement C1r-like protein.
GeneRIF
Fries et al., Uppsala, Sweden. In Proc Natl Acad Sci U S A, 2004
coexpression of the proform of Hp (proHp) and C1r-LP effected cleavage of proHp in the endoplasmic reticulum
A novel human dendritic cell-derived C1r-like serine protease analog inhibits complement-mediated cytotoxicity.
GeneRIF
Cao et al., Hangzhou, China. In Biochem Biophys Res Commun, 2004
CLSPa itself possesses little protease activity, but it plays an inhibitory role in other active protease catalytic processes
alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.
Review
Impact
Südhof, Dallas, United States. In Annu Rev Neurosci, 2000
In stimulating exocytosis, alpha-latrotoxin binds to two distinct families of neuronal cell-surface receptors, neurexins and CLs (Cirl/latrophilins), which probably have a physiological function in synaptic cell adhesion.
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