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Collectin sub-family member 11

CL-K1, Clk12
This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: MBL, CAN, V1a, AGE, L-ficolin
Papers on CL-K1
Correlation of Interleukin-6 levels and lectins during Schistosoma haematobium infection.
New
Velavan et al., Tübingen, Germany. In Cytokine, Dec 2015
IL-6 correlated with the lectins MBL, ficolin-2 and Collectin Kidney-1 (CL-K1) in cases, but correlated inversely in controls.
Collectin liver 1 and collectin kidney 1 and other complement-associated pattern recognition molecules in systemic lupus erythematosus.
New
Stengaard-Pedersen et al., Århus, Denmark. In Clin Exp Immunol, Nov 2015
The objective of this study was to explore the involvement of collectin liver 1 (CL-L1) and collectin kidney 1 (CL-K1) and other pattern recognition molecules (PRMs) of the lectin pathway of the complement system in a cross-sectional cohort of systemic lupus erythematosus (SLE) patients.
Endometriotic mesenchymal stem cells exhibit a distinct immune phenotype.
New
Madan et al., Mumbai, India. In Int Immunol, Apr 2015
Transcripts of PRRs such as all Toll-like receptors (TLR1-10), except TLR8, collectins (CL-L1, CL-P1 and CL-K1), NOD-1 and NOD-2 receptors and secreted pro-inflammatory cytokines like IL-6, IFN-γ, vascular endothelial growth factor (VEGF), epidermal growth factor and MCP-1 were significantly up-regulated in ectopic MSCs.
Lectin complement protein Collectin 11 (CL-K1) and susceptibility to urinary schistosomiasis.
New
Velavan et al., Tübingen, Germany. In Plos Negl Trop Dis, Mar 2015
Collectin Kidney 1 (CL-K1, encoded by COLEC11 on chromosome 2p25.3),
Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis.
Neyrolles et al., Toulouse, France. In Plos One, 2014
Mice deficient in CL-K1, one of the CL-LK subunits, do not display altered susceptibility to M. tuberculosis.
Genetic variation of COLEC10 and COLEC11 and association with serum levels of collectin liver 1 (CL-L1) and collectin kidney 1 (CL-K1).
Munthe-Fog et al., Copenhagen, Denmark. In Plos One, 2014
Collectin liver 1 (CL-L1, alias CL-10) and collectin kidney 1 (CL-K1, alias CL-11), encoded by the COLEC10 and COLEC11 genes, respectively, are highly homologous soluble pattern recognition molecules in the lectin pathway of complement.
Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome.
Wallis et al., San Diego, United States. In Bmc Biol, 2014
BACKGROUND: Collectin-K1 (CL-K1, or CL-11) is a multifunctional Ca(2+)-dependent lectin with roles in innate immunity, apoptosis and embryogenesis.
Calcium-sensitive immunoaffinity chromatography: Gentle and highly specific retrieval of a scarce plasma antigen, collectin-LK (CL-LK).
Hansen et al., Odense, Denmark. In J Immunol Methods, 2014
To evaluate the efficiency of this new purification scheme, we purified CL-LK using the same calcium-sensitive mAb in combination with acidic elution buffer and by using calcium-dependent anti-CL-K1 mAbs in combination with EDTA elution buffer.
Elevated plasma CL-K1 level is associated with a risk of developing disseminated intravascular coagulation (DIC).
Wakamiya et al., Boston, United States. In J Thromb Thrombolysis, 2014
Collectin kidney 1 (CL-K1) is a recently identified collectin that is synthesized in most organs and circulates in blood.
Heteromeric complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate the complement system.
Hansen et al., Odense, Denmark. In J Immunol, 2014
The complement cascade may be initiated downstream of the lectin activation pathway upon binding of mannan-binding lectin, ficolins, or collectin kidney 1 (CL-K1, alias CL-11) to suitable microbial patterns consisting of carbohydrates or acetylated molecules.
The lectin pathway of complement and rheumatic heart disease.
Review
de Messias-Reason et al., Curitiba, Brazil. In Front Pediatr, 2013
This pathway is initiated by the binding of mannose-binding lectin (MBL), collectin 11 (CL-K1), and ficolins (Ficolin-1, Ficolin-2, and Ficolin-3) to microbial surface oligosaccharides and acetylated residues, respectively.
Structure and function of collectin liver 1 (CL-L1) and collectin 11 (CL-11, CL-K1).
Review
Hansen et al., Denmark. In Immunobiology, 2012
Collectin liver 1 (CL-L1) and collectin 11 (CL-11, alias collectin kidney 1, CL-K1) are the more recently described members of this group.
Comparison of human blood concentrations of collectin kidney 1 and mannan-binding lectin.
GeneRIF
Wakamiya et al., Asahikawa, Japan. In J Biochem, 2012
Data show that the concentration of collectin kidney 1 (CL-K1, COLEC11) in plasma was 0.34 +/- 0.13 microg/ml and that in mannan-binding lectin (MBL) was 1.72 +/- 1.51 microg/ml.
Biological functions of the novel collectins CL-L1, CL-K1, and CL-P1.
Review
Wakamiya et al., Asahikawa, Japan. In J Biomed Biotechnol, 2011
These "novel collectins" consist of collectin liver 1 (CL-L1), collectin kidney 1 (CL-K1), and collectin placenta 1 (CL-P1) and are encoded by three separate genes.
Disease-causing mutations in genes of the complement system.
Review
Thiel et al., Århus, Denmark. In Am J Hum Genet, 2011
Furthermore, an association was discovered between 3MC syndrome and mutations in COLEC11, encoding CL-K1, another molecule of the lectin pathway.
Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome.
Impact
GeneRIF
Beales et al., London, United Kingdom. In Nat Genet, 2011
these findings demonstrate a role for complement pathway factors in fundamental developmental processes and in the etiology of 3MC syndrome.
Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity.
GeneRIF
Holmskov et al., Odense, Denmark. In J Immunol, 2010
CL-11 plays a role in activation of the complement system and in the defense against invading microorganisms
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