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CDC28 protein kinase regulatory subunit 1B

Cks1, CDC28 Protein Kinase, CKS1B
CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: PCNA, CAN, HAD, p27, Skp2
Papers on Cks1
Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.
New
Marshall et al., London, United Kingdom. In Elife, Feb 2016
This phenotype arises from down-regulation of the essential cell-cycle proteins CyclinA, CKS1 and CDK1.
Regulation of Transient Site-specific Copy Gain by microRNA.
New
Whetstine et al., United States. In J Biol Chem, Feb 2016
miRNA inhibition promoted copy gains and increased expression of the drug resistant oncogene CKS1B, which was further substantiated in primary breast tumors.
NEDD8 Inhibition Overcomes CKS1B-Induced Drug Resistance by Upregulation of p21 in Multiple Myeloma.
New
Zhan et al., Guangzhou, China. In Clin Cancer Res, Jan 2016
PURPOSE: CKS1B is significantly upregulated in multiple myeloma and associated with poor prognosis.
Cyclin-dependent kinase regulatory subunit 1 promotes cell proliferation by insulin regulation.
New
Zhao et al., Jinan, China. In Cell Cycle, Nov 2015
Cyclin-dependent kinase regulatory subunit 1 (CKS1) helps regulate the cell cycle to increase cell number.
Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan.
New
Nakamura et al., Isehara, Japan. In Mod Pathol, Oct 2015
The cases were characterized by immunohistochemistry, high-resolution oligonucleotide microarray, and fluorescence in situ hybridization (FISH) at five different loci: 1q21.3 (CKS1B), 6q16.3 (HACE1), 7p22.3 (MAFK), 9q33.3 (PPP6C), and 9q34.3 (ASS1, CARD9) using formalin-fixed paraffin-embedded sections.
The CDK subunit CKS2 counteracts CKS1 to control cyclin A/CDK2 activity in maintaining replicative fidelity and neurodevelopment.
GeneRIF
Yu et al., London, United Kingdom. In Dev Cell, 2012
show that CKS2 counteracts CKS1 and stabilizes p27
Cks1 promotion of S phase entry and proliferation is independent of p27Kip1 suppression.
GeneRIF
Keller et al., München, Germany. In Mol Cell Biol, 2012
establish p27(Kip1)-independent functions of Cks1 in regulating the G(1)-S transition
Cyclin kinase subunit 1B nuclear expression predicts an adverse outcome for patients with relapsed/refractory multiple myeloma treated with bortezomib.
GeneRIF
Chang et al., Toronto, Canada. In Hum Pathol, 2012
cyclin kinase subunit 1B nuclear expression detected by immunohistochemistry is an adverse prognostic factor for patients with multiple myeloma treated with bortezomib therapy
Overexpression of Cks1 increases the radiotherapy resistance of esophageal squamous cell carcinoma.
GeneRIF
Meng et al., Tianjin, China. In J Radiat Res (tokyo), 2011
Cks1 is overexpressed in esophageal squamous cell carcinoma tissues. Overexpression correlates with increased radiotherapy resistance of esophageal squamous cell carcinoma.
Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies.
GeneRIF
Keller et al., München, Germany. In Plos One, 2011
Cks1 is overexpressed in various B cell malignancies, is required for tumor cell proliferation but is not sufficient to induce hematopoietic malignancies.
Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma.
Review
Guan et al., Hong Kong, Hong Kong. In Acta Pharmacol Sin, 2010
Our research group and others, focused on the identification and characterization of 1q21 target genes such as JTB, CKS1B, and CHD1L in HCC progression.
Loss of cks1 homeostasis deregulates cell division cycle.
Review
Pillai et al., India. In J Cell Mol Med, 2010
cks1 overexpression reflects poor prognosis in malignancy thus indicating its possible role in tumour diagnosis and management.
Genetic and epigenetic control of molecular alterations in hepatocellular carcinoma.
Review
Pascale et al., Sassari, Italy. In Exp Biol Med (maywood), 2009
Unrestrained extracellular signal-regulated kinase (Erk) activity linked to proteasomal degradation of dual-specificity phosphatase 1 (Dusp1), a specific ERK inhibitor, by the CKS1-SKP2 ubiquitin ligase complex was highest in more aggressive HCC of genetically susceptible rats.
Gene expression profiling defines a high-risk entity of multiple myeloma.
Review
John D et al., Little Rock, United States. In Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2007
CKS1B located on chromosome 1q21, responsible for promoting cell cycle progression by inducing the degradation of p27Kip1, represented a strong candidate gene related to rapid patient death and was studied in detail.
Using genomics to identify high-risk myeloma after autologous stem cell transplantation.
Review
Barlogie et al., Little Rock, United States. In Biol Blood Marrow Transplant, 2006
Application of high-throughput genomics on a large uniformly untreated cohort of patients has revealed that activation of 1 of the 3 cyclin D genes is a universal initiating event in this disease and that acquisition of abnormalities of chromosome 1 leads to activation of CKS1B, a regulator of p27Kip1 degradation.
Rapid degradation of the G1 cyclin Cln2 induced by CDK-dependent phosphorylation.
Impact
Wittenberg et al., Los Angeles, United States. In Science, 1996
Cln2 phosphorylation is dependent on the Cdc28 protein kinase, the CDK that it activates.
The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae.
Impact
Nasmyth et al., Vienna, Austria. In Cell, 1994
All three events depend on activation of Cdc28 protein kinase by the G1 cyclins Cln1, -2, and -3.
Repression of growth-regulated G1 cyclin expression by cyclic AMP in budding yeast.
Impact
Alberghina et al., Milano, Italy. In Nature, 1994
It relies on the G1-specific cyclins encoded by CLN1, 2 and 3, which trigger Start through the activation of the Cdc28 protein kinase.
Inhibition of G1 cyclin activity by the Ras/cAMP pathway in yeast.
Impact
Futcher et al., New York City, United States. In Nature, 1994
The G1 cyclins Cln1, Cln2 and Cln3 activate the Cdc28 protein kinase and are rate-limiting activators of Start.
Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle.
Impact
Nasmyth et al., Vienna, Austria. In Cell, 1994
It is thought that DNA replication and mitosis in yeast are triggered by oscillations in the level of G1-specific (CLN1 and CLN2) and G2-specific (CLB1-CLB4) cyclins, which determine the substrate specificity of the CDC28 protein kinase.
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