GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Zinc finger and BTB domain containing 7B
cKrox, Zbtb7b, Thpok, hcKrox, zfp67
This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] (from
NCBI)
Papers on
cKrox
Cutting edge: fine-tuning of thpok gene activation by an enhancer in close proximity to its own silencer.
New
Yokohama, Japan. In J Immunol, 15 Mar 2013
Differentiation of MHC class II-selected thymocytes toward the CD4(+) helper lineage depends on function of the transcription factor ThPOK, whose expression is repressed in CD8(+) cytotoxic lineage cells by a transcriptional silencer activity within the distal regulatory element (DRE) in the Thpok gene.
Characterization and expression analysis of Th-POK from the Japanese pufferfish, Takifugu rubripes.
New
Miyazaki, Japan. In Comp Biochem Physiol B Biochem Mol Biol, 28 Feb 2013
The homology analysis of Fugu Th-POK (ZBTB7B) with other known ZBTB7 members (ZBTB7A, 7C) showed low identity, and the phylogenetic tree analysis showed the Fugu Th-POK clustered with the mammalian Th-POK, away from other ZBTB7 members.
Thpok-independent repression of Runx3 by Gata3 during CD4(+) T-cell differentiation in the thymus.
New
Bethesda, United States. In Eur J Immunol, 11 Feb 2013
The transcription factor Thpok is up-regulated in CD4-differentiating thymocytes and required to repress Runx3.
Enhanced hyaline cartilage matrix synthesis in collagen sponge scaffolds by using siRNA to stabilize chondrocytes phenotype cultured with BMP-2 under hypoxia.
New
Caen, France. In Tissue Eng Part C Methods, Jan 2013
The specific increase in COL2A1 gene expression observed in the BMP-2 treatment was shown to involve the specific enhancer region of COL2A1 that binds the transactivators Sox9/L-Sox5/Sox6 and Sp1, which are associated with a decrease in the transinhibitors of COL2A1, c-Krox and p65 subunit of NF-kappaB.
ZBTB7B (Th-POK) regulates the development of IL-17-producing CD1d-restricted mouse NKT cells.
New
Canberra, Australia. In J Immunol, Jan 2013
In this study, we analyze a novel mouse strain (helpless) with a mis-sense mutation in the BTB-POZ domain of ZBTB7B and demonstrate that this mutation has dramatic, intrinsic effects on development of NKT cell subsets.
SDS3 interacts with ARNT in an AhR ligand-specific manner regulating expression of cKrox and S100A4 in CD4+CD8+ DPK thymocytes differentiation.
New
Ch'angwŏn, South Korea. In Environ Toxicol Pharmacol, Nov 2012
Expression of cKrox S100A4 was derepressed when SDS3 protein was reduced.
The transcription factors Thpok and LRF are necessary and partly redundant for T helper cell differentiation.
New
Impact
Bethesda, United States. In Immunity, Nov 2012
Here, we showed that the two transcription factors Thpok and LRF share this function.
DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina.
New
Impact
Chicago, United States. In Cell, Jul 2012
This repeated motif directs lamina association and is bound by the transcriptional repressor cKrox, in a complex with HDAC3 and Lap2β.
Genetic and epigenetic mechanisms collaborate to control SERPINA3 expression and its association with placental diseases.
New
Paris, France. In Hum Mol Genet, Jun 2012
In the present study, we show that the promoter of SERPINA3 is transcriptionally activated by three transcription factors (TFs) (SP1, MZF1 and ZBTB7B), the level of induction being dependent on the rs1884082 single nucleotide polymorphism (SNP) located inside the promoter, the T allele being consistently induced to a higher level than the G, with or without added TFs.
The enigma of CD4-lineage specification.
Review
Bethesda, United States. In Eur J Immunol, 2011
This review discusses recently identified nodes in the transcriptional circuits that are involved in controlling CD4(+) T-cell differentiation, notably the commitment factor Thpok and its interplay with Runx transcriptional regulators, and focuses on how transcription factors acting upstream of Thpok, including Gata3, Tox and E-box proteins, promote the emergence of CD4-lineage-specific gene expression patterns.
p300-mediated acetylation stabilizes the Th-inducing POK factor.
GeneRIF
Shanghai, China. In J Immunol, 2010
impairment of Lck-mediated CD4 coreceptor signaling by Nef is an important in vivo mechanism of HIV-1 pathogenesis
The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells.
GeneRIF
Bethesda, United States. In Eur J Immunol, 2010
required for the differentiation of CD1d-restricted CD4+ NKT cells
Identification of important regulatory region of Th-POK.
GeneRIF
Tokushima, Japan. In J Med Invest, 2010
comparing the promoter regions of the Th-POK gene between human and mouse, the region 3600 base pairs upstream from the transcription initiation site of the Th-POK gene was highly conserved
TCR-mediated ThPOK induction promotes development of mature (CD24-) gammadelta thymocytes.
GeneRIF
Philadelphia, United States. In Embo J, 2010
Data show that ThPOK expression in gammadelta thymocytes is regulated by TCR signalling, that ThPOK is an important mediator of gammadelta T cell development/maturation, and that development of some gammadelta T cells depends on TCR engagement/signalling.
Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3.
GeneRIF
New York City, United States. In J Immunol, 2010
Broad-complex and BTB-ZF gene ThPOK is a member of the tramtrack bric-a;-brac (BTB)-poxvirus-zinc finger family of transcription factors and is important for the phenotype of promyelocytic leukemia zinc finger (PLZF)-expressing gamma delta T cells.
CD4-CD8 lineage differentiation: Thpok-ing into the nucleus.
Review
GeneRIF
Bethesda, United States. In J Immunol, 2009
Review summarizes recent advances on the regulatory function of transcription factor Thpok, a zinc finger protein which is required for CD4 T-cell lineage differentiation.
The transcription factor PLZF directs the effector program of the NKT cell lineage.
Impact
Chicago, United States. In Immunity, 2008
We report that PLZF (promyelocytic leukemia zinc finger, Zbtb16), a member of the BTB/POZ-ZF family of transcription factors that includes the CD4-lineage-specific c-Krox (Th-POK), is exquisitely specific to CD1d-restricted NKT cells and human MR1-specific MAIT cells.
The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection.
Impact
GeneRIF
Bethesda, United States. In Nat Immunol, 2005
Th-POK directs CD4 lineage differentiation during intrathymic T-cell positive selection.
Biology of the scleroderma fibroblast.
Review
Boston, United States. In Curr Opin Rheumatol, 1998
In addition to these studies in scleroderma fibroblasts, work elucidating the role of transcription factors Sp1, Sp3, and cKrox in regulating collagen metabolism provided important data upon which future studies may build.
Regulation of type I collagen genes expression.
Review
Houston, United States. In Int Rev Immunol, 1994
A second one is centered by a G-rich region and it binds a new transcription factor called C-Krox.(ABSTRACT
