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Zinc finger and BTB domain containing 7B

cKrox, Zbtb7b, Thpok, hcKrox, zfp67
This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: CD4, CD8, MHC, CAN, SP1
Papers on cKrox
CD4 CTL: living up to the challenge.
New
Husain et al., Los Angeles, United States. In Semin Immunol, Dec 2013
This lineage dichotomy is controlled by key transcription factors, including the T helper (Th) lineage master regulator, the Th-inducing BTB/POZ domain-containing Kruppel-like zinc-finger transcription factor, ThPOK, (formally cKrox or Zfp67; encoded by Zbtb7b), which suppresses the cytolytic program in major histocompatibility complex (MHC) class II-restricted CD4(+) thymocytes and the Runt related transcription factor 3 (Runx3), which counteracts ThPOK in MHC class I restricted precursor cells and promotes the lineage commitment of CD8αβ(+) cytolytic T lymphocytes (CTL).
Enhanced hyaline cartilage matrix synthesis in collagen sponge scaffolds by using siRNA to stabilize chondrocytes phenotype cultured with bone morphogenetic protein-2 under hypoxia.
New
Demoor et al., Caen, France. In Tissue Eng Part C Methods, Jul 2013
The specific increase in COL2A1 gene expression observed in the BMP-2 treatment was shown to involve the specific enhancer region of COL2A1 that binds the trans-activators Sox9/L-Sox5/Sox6 and Sp1, which are associated with a decrease in the trans-inhibitors of COL2A1, c-Krox, and p65 subunit of NF-kappaB.
Epigenetic Thpok silencing limits the time window to choose CD4(+) helper-lineage fate in the thymus.
New
Taniuchi et al., Yokohama, Japan. In Embo J, May 2013
Commitment to the helper lineage depends on persistent TCR signals and expression of the ThPOK transcription factor, whereas a ThPOK cis-regulatory element, ThPOK silencer, represses Thpok gene expression during commitment to the cytotoxic lineage.
Thpok-independent repression of Runx3 by Gata3 during CD4+ T-cell differentiation in the thymus.
New
Bosselut et al., Bethesda, United States. In Eur J Immunol, Apr 2013
The transcription factor Thpok is upregulated in CD4-differentiating thymocytes and required to repress Runx3.
Cutting edge: fine-tuning of Thpok gene activation by an enhancer in close proximity to its own silencer.
New
Taniuchi et al., Yokohama, Japan. In J Immunol, Mar 2013
Differentiation of MHC class II-selected thymocytes toward the CD4(+) helper lineage depends on function of the transcription factor ThPOK, whose expression is repressed in CD8(+) cytotoxic lineage cells by a transcriptional silencer activity within the distal regulatory element (DRE) in the Thpok gene.
Characterization and expression analysis of Th-POK from the Japanese pufferfish, Takifugu rubripes.
New
Kono et al., Miyazaki, Japan. In Comp Biochem Physiol B Biochem Mol Biol, Feb 2013
The homology analysis of Fugu Th-POK (ZBTB7B) with other known ZBTB7 members (ZBTB7A, 7C) showed low identity, and the phylogenetic tree analysis showed the Fugu Th-POK clustered with the mammalian Th-POK, away from other ZBTB7 members.
Stage-specific epigenetic gene silencing during thymocyte lineage commitment.
Taniuchi, Yokohama, Japan. In F1000prime Rep, 2012
Gene regulation at the Cd4 and Thpok loci provides ideal models for developmentally regulated gene silencing.
The transcription factors Thpok and LRF are necessary and partly redundant for T helper cell differentiation.
Impact
Bosselut et al., Bethesda, United States. In Immunity, 2012
Here, we showed that the two transcription factors Thpok and LRF share this function.
Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation.
GeneRIF
Liu et al., Shanghai, China. In J Immunol, 2012
ThPOK transgene stably represses CD8 gene expression through the deacetylation of Cd8 loci in CD4 cell lineage commitment.
DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina.
Impact
Singh et al., Chicago, United States. In Cell, 2012
This repeated motif directs lamina association and is bound by the transcriptional repressor cKrox, in a complex with HDAC3 and Lap2β.
The p65 subunit of NF-κB inhibits COL1A1 gene transcription in human dermal and scleroderma fibroblasts through its recruitment on promoter by protein interaction with transcriptional activators (c-Krox, Sp1, and Sp3).
GeneRIF
Galera et al., Caen, France. In J Biol Chem, 2012
The p65 subunit of NF-kappaB inhibits COL1A1 gene transcription in human dermal and scleroderma fibroblasts through its recruitment on promoter by protein interaction with transcriptional activators (c-Krox, Sp1, and Sp3).
The enigma of CD4-lineage specification.
Review
Bosselut et al., Bethesda, United States. In Eur J Immunol, 2011
This review discusses recently identified nodes in the transcriptional circuits that are involved in controlling CD4(+) T-cell differentiation, notably the commitment factor Thpok and its interplay with Runx transcriptional regulators, and focuses on how transcription factors acting upstream of Thpok, including Gata3, Tox and E-box proteins, promote the emergence of CD4-lineage-specific gene expression patterns.
p300-mediated acetylation stabilizes the Th-inducing POK factor.
GeneRIF
Liu et al., Shanghai, China. In J Immunol, 2010
impairment of Lck-mediated CD4 coreceptor signaling by Nef is an important in vivo mechanism of HIV-1 pathogenesis
The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells.
GeneRIF
Bosselut et al., Bethesda, United States. In Eur J Immunol, 2010
required for the differentiation of CD1d-restricted CD4+ NKT cells
Identification of important regulatory region of Th-POK.
GeneRIF
Shamsul Alam, Tokushima, Japan. In J Med Invest, 2010
comparing the promoter regions of the Th-POK gene between human and mouse, the region 3600 base pairs upstream from the transcription initiation site of the Th-POK gene was highly conserved
CD4-CD8 lineage differentiation: Thpok-ing into the nucleus.
Review
GeneRIF
Bosselut et al., Bethesda, United States. In J Immunol, 2009
Review summarizes recent advances on the regulatory function of transcription factor Thpok, a zinc finger protein which is required for CD4 T-cell lineage differentiation.
The transcription factor PLZF directs the effector program of the NKT cell lineage.
Impact
Bendelac et al., Chicago, United States. In Immunity, 2008
We report that PLZF (promyelocytic leukemia zinc finger, Zbtb16), a member of the BTB/POZ-ZF family of transcription factors that includes the CD4-lineage-specific c-Krox (Th-POK), is exquisitely specific to CD1d-restricted NKT cells and human MR1-specific MAIT cells.
The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection.
Impact
GeneRIF
Bosselut et al., Bethesda, United States. In Nat Immunol, 2005
Th-POK directs CD4 lineage differentiation during intrathymic T-cell positive selection.
Biology of the scleroderma fibroblast.
Review
Korn et al., Boston, United States. In Curr Opin Rheumatol, 1998
In addition to these studies in scleroderma fibroblasts, work elucidating the role of transcription factors Sp1, Sp3, and cKrox in regulating collagen metabolism provided important data upon which future studies may build.
Regulation of type I collagen genes expression.
Review
Park et al., Houston, United States. In Int Rev Immunol, 1994
A second one is centered by a G-rich region and it binds a new transcription factor called C-Krox.(ABSTRACT
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