The enigma of CD4-lineage specification.
Bethesda, United States. In Eur J Immunol, 2011
This review discusses recently identified nodes in the transcriptional circuits that are involved in controlling CD4(+) T-cell differentiation, notably the commitment factor Thpok and its interplay with Runx transcriptional regulators, and focuses on how transcription factors acting upstream of Thpok, including Gata3, Tox and E-box proteins, promote the emergence of CD4-lineage-specific gene expression patterns.
Identification of important regulatory region of Th-POK.
Tokushima, Japan. In J Med Invest, 2010
comparing the promoter regions of the Th-POK gene between human and mouse, the region 3600 base pairs upstream from the transcription initiation site of the Th-POK gene was highly conserved
Biology of the scleroderma fibroblast.
Boston, United States. In Curr Opin Rheumatol, 1998
In addition to these studies in scleroderma fibroblasts, work elucidating the role of transcription factors Sp1, Sp3, and cKrox in regulating collagen metabolism provided important data upon which future studies may build.