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Casein kinase 1, epsilon

CKIepsilon, Casein Kinase Iepsilon, CK1epsilon, CSNK1E, casein kinase 1 epsilon
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CLOCK, CKI, period 2, CAN, period 3
Papers on CKIepsilon
Identification of circadian gene variants in bipolar disorder in Latino populations.
New
Escamilla et al., El Paso, United States. In J Affect Disord, Dec 2015
These included CSNK1E (rs1534891, p=0.00689),
Low cytoplasmic casein kinase 1 epsilon expression predicts poor prognosis in patients with hepatocellular carcinoma.
New
Yang et al., T'ai-chung-shih, Taiwan. In Tumour Biol, Nov 2015
UNASSIGNED: Casein kinase 1 epsilon (CK1ε) is a member of the casein kinase 1 (CK1) family, which comprises highly conserved and ubiquitous serine/threonine protein kinases.
High casein kinase 1 epsilon levels are correlated with better prognosis in subsets of patients with breast cancer.
New
Carnero et al., Sevilla, Spain. In Oncotarget, Nov 2015
We investigated the association between casein kinase 1 epsilon (CK1ε) and the risk of recurrence in patients with BC.
Systematic analysis of circadian genes using genome-wide cDNA microarrays in the inflammatory bowel disease transcriptome.
New
Latiano et al., In Chronobiol Int, Aug 2015
Conversely, ARNTL2, CRY1, CSNK1E, RORA and TIPIN were up-regulated, while NR1D2 and PER3 were down-regulated in UC.
KNOCKDOWN OF CASEIN KINASE 1e INHIBITS CELL PROLIFERATION AND INVASION OF COLORECTAL CANCER CELLS VIA INHIBITION OF THE Wnt/β-CATENIN SIGNALING.
New
Qiu et al., Shanghai, China. In J Biol Regul Homeost Agents, Apr 2015
Deregulation of casein kinase 1 epsilon (CK1ε) is involved in the development of multiple pathological disorders such as cancer, however the function and molecular mechanism of CK1εin cancer are still unclear.
A PER3 polymorphism is associated with better overall survival in diffuse large B-cell lymphoma in Mexican population.
Scott et al., Monterrey, Mexico. In Cancer Biomark, 2014
METHODS: Sixteen high-risk non-synonymous polymorphisms in circadian genes (CLOCK, CRY2, CSNK1E, CSNK2A1, NPAS2, PER1, PER2, PER3, PPP2CA, and TIM) were genotyped by screening PCR.
Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway.
GeneRIF
Lee et al., Bethesda, United States. In Embo J, 2012
Identification of a novel Wnt5a-CK1varepsilon-Dvl2-Plk1-mediated primary cilia disassembly pathway.
Csnk1e is a genetic regulator of sensitivity to psychostimulants and opioids.
GeneRIF
Palmer et al., Chicago, United States. In Neuropsychopharmacology, 2012
A narrow genetic locus containing Csnk1e is associated with differences in sensitivity to methamphetamine (MA) and fentanyl; variation at the Csnk1e locus can regulate the locomotor response to MA.
Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock.
GeneRIF
Fu et al., San Francisco, United States. In Plos One, 2011
Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock
Kinetics of doubletime kinase-dependent degradation of the Drosophila period protein.
GeneRIF
Young et al., New York City, United States. In J Biol Chem, 2011
kinetics of PER degradation with DBT(S) in cell culture resembles that with wild-type DBT and posits that, in flies DBT(S) likely does not modulate the clock by simply affecting PER degradation kinetics
CK1ε targets Cdc25A for ubiquitin-mediated proteolysis under normal conditions and in response to checkpoint activation.
GeneRIF
Ha et al., Pusan, South Korea. In Cell Cycle, 2011
CK1epsilon regulates the cellular levels of Cdc25A in parallel with Chk1-dependent Cdc25A degradation, contributing to the precise control of cell division.
WNT signaling pathway and stem cell signaling network.
Review
Katoh et al., Japan. In Clin Cancer Res, 2007
Microtubule affinity-regulating kinase (PAR-1) family kinases, casein kinase I epsilon (CKI epsilon), and FRAT are positive regulators of the canonical WNT pathway, whereas APC, AXIN1, AXIN2, CKI alpha, NKD1, NKD2, beta TRCP1, beta TRCP2, ANKRD6, Nemo-like kinase (NLK), and peroxisome proliferator-activated receptor gamma (PPAR gamma) are negative regulators.
Circadian rhythms in the CNS and peripheral clock disorders: human sleep disorders and clock genes.
Review
Ebisawa, Tokyo, Japan. In J Pharmacol Sci, 2007
As for DSPS, a missense variation in the Per3 gene is identified as a risk factor, while the one in the CK1epsilon gene is thought to be protective.
Reversible protein phosphorylation regulates circadian rhythms.
Review
Harnish et al., Salt Lake City, United States. In Cold Spring Harb Symp Quant Biol, 2006
Casein kinase Iepsilon is a protein kinase that regulates the circadian clock by periodic phosphorylation of the proteins PER1 and PER2, controlling their stability and localization.
Genetics and neurobiology of circadian clocks in mammals.
Review
Takahashi et al., Evanston, United States. In Cold Spring Harb Symp Quant Biol, 2006
In mammals, there is a "core" set of circadian genes that form the primary negative feedback loop of the clock mechanism (Clock/Npas2, Bmal1, Per1, Per2, Cry1, Cry2, and CK1epsilon).
The biology of the circadian Ck1epsilon tau mutation in mice and Syrian hamsters: a tale of two species.
Review
Hastings et al., Manchester, United Kingdom. In Cold Spring Harb Symp Quant Biol, 2006
The tau mutation in the Syrian hamster resides in the enzyme casein kinase 1 epsilon (CK1epsilon), resulting in a dramatic acceleration of wheel-running activity cycles to about 20 hours.
Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime.
Impact
GeneRIF
Edery et al., United States. In Nature, 2003
Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime
Posttranslational mechanisms regulate the mammalian circadian clock.
Impact
Reppert et al., Worcester, United States. In Cell, 2002
These proteins, the cryptochromes (mCRY1 and mCRY2), and casein kinase I epsilon (CKIepsilon) form multimeric complexes that are bound to DNA during negative transcriptional feedback.
An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.
Impact
Fu et al., Salt Lake City, United States. In Science, 2001
Affected individuals have a serine to glycine mutation within the casein kinase Iepsilon (CKIepsilon) binding region of hPER2, which causes hypophosphorylation by CKIepsilon in vitro.
Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.
Impact
Takahashi et al., Evanston, United States. In Science, 2000
The tau locus is encoded by casein kinase I epsilon (CKIepsilon), a homolog of the Drosophila circadian gene double-time.
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