A PER3 polymorphism is associated with better overall survival in diffuse large B-cell lymphoma in Mexican population.
Monterrey, Mexico. In Cancer Biomark, 2014
METHODS: Sixteen high-risk non-synonymous polymorphisms in circadian genes (CLOCK, CRY2, CSNK1E, CSNK2A1, NPAS2, PER1, PER2, PER3, PPP2CA, and TIM) were genotyped by screening PCR.
WNT signaling pathway and stem cell signaling network.
Japan. In Clin Cancer Res, 2007
Microtubule affinity-regulating kinase (PAR-1) family kinases, casein kinase I epsilon (CKI epsilon), and FRAT are positive regulators of the canonical WNT pathway, whereas APC, AXIN1, AXIN2, CKI alpha, NKD1, NKD2, beta TRCP1, beta TRCP2, ANKRD6, Nemo-like kinase (NLK), and peroxisome proliferator-activated receptor gamma (PPAR gamma) are negative regulators.
Reversible protein phosphorylation regulates circadian rhythms.
Salt Lake City, United States. In Cold Spring Harb Symp Quant Biol, 2006
Casein kinase Iepsilon is a protein kinase that regulates the circadian clock by periodic phosphorylation of the proteins PER1 and PER2, controlling their stability and localization.
Genetics and neurobiology of circadian clocks in mammals.
Evanston, United States. In Cold Spring Harb Symp Quant Biol, 2006
In mammals, there is a "core" set of circadian genes that form the primary negative feedback loop of the clock mechanism (Clock/Npas2, Bmal1, Per1, Per2, Cry1, Cry2, and CK1epsilon).