gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Casein kinase 1, alpha 1

CKI, CK1, CKIalpha
splice variant isoforms CKI alpha and CKI alpha L both have casein kinase I activity but display differences in substrate kinetics [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: PCNA, CAN, p27, p21, ACID
Papers using CKI antibodies
Characterization of antihuman IFNAR-1 monoclonal antibodies: epitope localization and functional analysis.
Supplier
Diamond Michael S., In PLoS Pathogens, 1998
... CK1 inhibitor D4476 was from Tocris.
Papers on CKI
Decreased CK1δ expression predicts prolonged survival in colorectal cancer patients.
New
Knippschild et al., Ulm, Germany. In Tumour Biol, Feb 2016
Since casein kinase 1 (CK1) isoforms are involved in many cellular processes and have been reported to be deregulated in various tumor entities, CK1 has become an interesting drug target.
Fam83h null mice support a neomorphic mechanism for human ADHCAI.
New
Simmer et al., Montréal, Canada. In Mol Genet Genomic Med, Jan 2016
Casein kinase 1 (CK1) interacts with the FAM83H PLD-like domain via an F(270)-X-X-X-F(274)-X-X-X-F(278) motif.
Dynamic conformational ensembles regulate casein kinase-1 isoforms: Insights from molecular dynamics and molecular docking studies.
New
Gupta et al., Allahābād, India. In Comput Biol Chem, Jan 2016
UNASSIGNED: Casein kinase-1 (CK1) isoforms actively participate in the down-regulation of canonical Wnt signaling pathway; however recent studies have shown their active roles in oncogenesis of various tissues through this pathway.
Histone Deacetylase Inhibitors Increase p27(Kip1) by Affecting Its Ubiquitin-Dependent Degradation through Skp2 Downregulation.
New
Della Ragione et al., Napoli, Italy. In Oxid Med Cell Longev, Dec 2015
Here, we evaluated the effects of HDACIs on p27(Kip1), a key cyclin-dependent kinase inhibitor (CKI).
Host cell kinases and the hepatitis C virus life cycle.
Review
New
Baumert et al., Strasbourg, France. In Biochim Biophys Acta, Oct 2015
The phosphorylation status of NS5a, regulated by PI4KIIIα, CKI and other kinases, also acts as a molecular switch to virion assembly, which takes place on lipid droplets.
The generation of phosphoserine stretches in phosphoproteins: mechanism and significance.
Review
New
Pinna et al., Padova, Italy. In Mol Biosyst, Oct 2015
Also well documented is the combined intervention of CK1 and GSK3, the former acting as priming and primed, the latter as primed kinase.
Malaria Parasite-Infected Erythrocytes Secrete PfCK1, the Plasmodium Homologue of the Pleiotropic Protein Kinase Casein Kinase 1.
Doerig et al., Paris, France. In Plos One, 2014
Casein kinase 1 (CK1) is a pleiotropic protein kinase implicated in several fundamental processes of eukaryotic cell biology.
TTBK2: a tau protein kinase beyond tau phosphorylation.
Review
Chang et al., Taipei, Taiwan. In Biomed Res Int, 2014
TTBK2 possesses a casein kinase 1 (CK1) kinase domain followed by a ~900 amino acid segment, potentially responsible for its localization and substrate recruitment.
MYC-mediated synthetic lethality for treating tumors.
Review
Huang et al., Wuhan, China. In Curr Cancer Drug Targets, 2014
An SMI can induce MYC-SL by increasing MYC expression through the inactivation of the GSK3β/FBW7 axis and CK1.
Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis.
Review
Sinnberg et al., Tübingen, Germany. In Mol Cancer, 2013
Isoforms of the casein kinase 1 (CK1) family have been shown to phosphorylate key regulatory molecules involved in cell cycle, transcription and translation, the structure of the cytoskeleton, cell-cell adhesion and receptor-coupled signal transduction.
Glucose-induced regulation of protein import receptor Tom22 by cytosolic and mitochondria-bound kinases.
Impact
Meisinger et al., Freiburg, Germany. In Cell Metab, 2013
Casein kinase 2 (CK2) constitutively phosphorylates the cytosolic precursor of Tom22 at Ser44 and Ser46 and, thus, promotes its import.
RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling.
Impact
Niehrs et al., Heidelberg, Germany. In Science, 2013
Casein kinase 1 (CK1) members play key roles in numerous biological processes.
MiR-155 is a liposarcoma oncogene that targets casein kinase-1α and enhances β-catenin signaling.
GeneRIF
Lev et al., Houston, United States. In Cancer Res, 2012
identified casein kinase 1alpha (CK1alpha) as a direct target of miR-155 control which enhanced beta-catenin signaling and cyclin D1 expression, promoting tumor cell growth
Four-gene expression model predictive of lymph node metastases in oral squamous cell carcinoma.
GeneRIF
Federico et al., São Paulo, Brazil. In Acta Oncol, 2012
We showed that just four genes, G3BP2, SCARB2, CSNK1A1 and SPRR2B, can classify patients as presence of lymph node metastasis negative or positive, with 80.0% accuracy.
mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR.
GeneRIF
Pagano et al., New York City, United States. In Mol Cell, 2011
mTOR cooperates with CK1alpha and betaTrCP to generate an auto-amplification loop to promote its own full activation.
CKIα ablation highlights a critical role for p53 in invasiveness control.
Impact
GeneRIF
Ben-Neriah et al., Jerusalem, Israel. In Nature, 2011
maintenance of intestinal homeostasis in CKIalpha-deficient gut requires p53-mediated growth control, because the combined ablation of Csnk1a1 and either p53 or its target gene p21 triggered high-grade dysplasia with extensive proliferation
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.
Impact
Wei et al., Boston, United States. In Cancer Cell, 2010
Here, we report that Mdm2 is rapidly degraded after DNA damage and that phosphorylation of Mdm2 by casein kinase I (CKI) at multiple sites triggers its interaction with, and subsequent ubiquitination and destruction, by SCF(beta-TRCP).
Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase.
Impact
Watanabe et al., Tokyo, Japan. In Nat Cell Biol, 2010
Using a genetic screen for 'anti-shugoshin', we identify Hhp2, an orthologue of casein kinase 1delta/epsilon (CK1), as a factor required for Rec8 cleavage in fission yeast.
High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase.
GeneRIF
Kay et al., San Diego, United States. In Plos Biol, 2009
The authors characterized the role of CKIalpha in the clock mechanism and found that CKIalpha-mediated phosphorylation stimulated degradation of a clock protein PER1, similar to the function of CKIdelta.
Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms.
Impact
Reiter et al., San Francisco, United States. In Nat Cell Biol, 2008
Blocking the activity of casein kinase I (CKI) reverses this constitutive Dvl phosphorylation and abrogates pathway hyper-responsiveness.
share on facebooktweetadd +1mail to friends