GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Creatine kinase, brain
CKB, brain creatine kinase, creatine kinase B, CKBB, B-CK
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008] (from
NCBI)
Sponsored links
Papers on
CKB
Low oxygen tension enhances hepatitis C virus replication.
New
Athens, Greece. In J Virol, 31 Mar 2013
Interestingly, hypoxia-mediated enhancement of HCV replication correlated directly with the increase in anaerobic glycolysis and creatine kinase B (CKB) activity that leads to elevated ATP production.
Proteomics reveals intersexual differences in the rat brain hippocampus.
New
Xi'an, China. In Anat Rec (hoboken), 31 Mar 2013
In line with Western-blotting validation, the proteomic identification revealed the overexpression of glial fibrillary acidic protein in female rats' hippocampi, and the overexpression of both creatine kinase B-type and DRP-2 in male rats' hippocampi.
A nontargeted proteomic study of the influence of androgen excess on human visceral and subcutaneous adipose tissue proteomes.
New
Madrid, Spain. In J Clin Endocrinol Metab, 31 Mar 2013
Results: The abundance of 2 spots of peroxiredoxin 6, creatine kinase B-type, 2 spots of selenium-binding protein 1, ruvB-like 2, 4-trimethylaminobutyraldehyde dehydrogenase, and albumin were higher in VAT compared with SAT in women with polycystic ovary syndrome.
Enhancement of brain-type creatine kinase activity ameliorates neuronal deficits in Huntington's disease.
New
Taipei, Taiwan. In Biochim Biophys Acta, 14 Mar 2013
Brain-type creatine kinase (CKB) is an enzyme involved in energy homeostasis via the phosphocreatine-creatine kinase system.
Knockdown of creatine kinase B inhibits ovarian cancer progression by decreasing glycolysis.
New
Beijing, China. In Int J Biochem Cell Biol, 14 Mar 2013
Creatine kinase B (CKB), a cytosolic isoform of creatine kinase, shows upregulated expression in a variety of cancers.
Enteroviruses and the pathogenesis of type 1 diabetes revisited: Cross-reactivity of enterovirus capsid protein (VP1) antibodies with human mitochondrial proteins.
New
Göteborg, Sweden. In J Pathol, 17 Feb 2013
We found a distinct reactivity with two mitochondrial proteins, creatine kinase B-type and ATP synthase beta subunit.
Expression and localisation of creatine kinase in the preimplantation embryo.
New
York, United Kingdom. In Mol Reprod Dev, Jan 2013
Using quantitative PCR, transcripts of 4 subunit isoforms of CK - CKM, CKB, CKMT1 and CKMT2 - were detectable at all developmental stages, from the presumptive zygote to late blastocyst, but there was no obvious pattern in gene expression.
Energy dysfunction in Huntington's disease: insights from PGC-1α, AMPK, and CKB.
Review
New
Taipei, Taiwan. In Cell Mol Life Sci, Dec 2012
This review focuses on the importance of three key molecular determinants (peroxisome proliferator-activated receptor-γ coactivator-1α, AMP-activated protein kinase, and creatine kinase B) of cellular energy homeostasis and their possible involvement in HD pathogenesis.
Label-free quantitative proteomics of CD133-positive liver cancer stem cells.
Taipei, Taiwan. In Proteome Sci, 2011
The results were further validated by RT-PCR, western blot, flow cytometry or immunofluorescent staining which revealed that prominin-1, annexin A1, annexin A3, transgelin, creatine kinase B, vimentin, and EpCAM were indeed highly expressed in the CD133-positive hepatoma cells.
Besides Huntington's disease, does brain-type creatine kinase play a role in other forms of hearing impairment resulting from a common pathological cause?
Review
Taipei, Taiwan. In Aging (albany Ny), 2011
We also showed that dietary creatine supplementation rescued the impaired PCr-CK system and improved the expression of cochlear brain-type creatine kinase (CKB) in HD mice, thereby restoring their hearing.
Creatine kinase brain overexpression protects colorectal cells from various metabolic and non-metabolic stresses.
GeneRIF
Baltimore, United States. In J Cell Biochem, 2011
Data demonstrate that the downregulation of CKB may play an important role in colon cancer progression by promoting EMT.
Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington disease.
GeneRIF
Taipei, Taiwan. In J Clin Invest, 2011
reduced expression of brain creatine kinase in the cochlea of Huntington disease mice is associated with hearing impairment
Generation of the oxidized form protects human brain type creatine kinase against cystine-induced inactivation.
GeneRIF
Beijing, China. In Int J Biol Macromol, 2011
These observations suggested that the ability to generate the oxidized form could protect BBCK against the intracellular oxidative stress.
Implications of efavirenz for neuropsychiatry: a review.
Review
Fortaleza, Brazil. In Int J Neurosci, 2010
The mechanisms involved in these changes include interference with cytochrome P450 enzymes, cytokines, tryptophan-2-3-dioxygenase, and brain creatine kinase.
Association of creatin kinase B and peroxiredoxin 2 expression with age and embryo quality in cumulus cells.
GeneRIF
T'ai-chung-shih, Taiwan. In J Assist Reprod Genet, 2010
CKB was up-regulated in women older than 38 years, and its expression in cumulus cells was associated with embryo quality
Predictive value of cardiac troponin-I compared to creatine kinase-myocardial band for the assessment of infarct size as measured by cardiac magnetic resonance.
GeneRIF
Udine, Italy. In J Cardiovasc Med (hagerstown), 2010
A single troponin I value at 3 days from symptom onset is a better predictor of infarct size compared to peak values and CK-MB.
Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption.
Impact
GeneRIF
Seoul, South Korea. In Nat Med, 2008
Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption.
Approaching the multifaceted nature of energy metabolism: inactivation of the cytosolic creatine kinases via homologous recombination in mouse embryonic stem cells.
Review
Nijmegen, Netherlands. In Mol Cell Biochem, 1994
Using targeting constructs based on strain 129/Sv isogenic DNA we managed to ablate the essential exons of the B-CK and M-CK genes at reasonably high frequencies.
Sequence homology and structure predictions of the creatine kinase isoenzymes.
Review
Zürich, Switzerland. In Mol Cell Biochem, 1994
A 'CK framework' is defined, consisting of the most conserved sequence blocks, and 'diagnostic boxes' are identified which are characteristic for anyone creatine kinase isoenzyme (e.g. for vertebrate B-CK) and which may serve to distinguish this isoenzyme from all others (e.g. from M-CKs and Mi-CKs).
Reversal of creatine kinase translational repression by 3' untranslated sequences.
Impact
Durham, United States. In Science, 1990
A subline of U937 cells (U937D) was obtained in which creatine kinase B (CK-B) messenger RNA was present and bound to ribosomes, but CK activity was undetectable.
