Proteomic analysis of cerebrospinal fluid in canine cervical spondylomyelopathy.
Madrid, Spain. In Spine (phila Pa 1976), Jun 2015
Compared with the CSF of control dogs, CSM-affected dogs demonstrated increased CSF expression of 8 proteins including vitamin D-binding protein, gelsolin, creatine kinase B-type, angiotensinogen, α-2-HS-glycoprotein, SPARC (secreted protein, acidic, rich in cysteine), calsyntenin-1, and complement C3, and decreased expression of pigment epithelium-derived factor, prostaglandin-H2 D-isomerase, apolipoprotein E, and clusterin.
Neuronal toxicity of efavirenz: a systematic review.
Stellenbosch, South Africa. In Expert Opin Drug Saf, 2013
Several potential mechanisms exist to explain the observed efavirenz neurotoxicity, including altered calcium hemostasis, decreases in brain creatine kinase, mitochondrial damage, increases in brain proinflammatory cytokines and involvement of the cannabinoid system.