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Creatine kinase, brain

CKB, brain creatine kinase, creatine kinase B, CKBB, B-CK
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, muscle creatine kinase, CAN, ACID, fibrillin-1
Papers on CKB
Differential protein expression in the nucleus accumbens of high and low active mice.
New
Lightfoot et al., Houston, United States. In Behav Brain Res, 15 Oct 2015
Low active mice generally over expressed proteins associated with neural stress (Stress 70 protein and V type proton ATPase catalytic subunit A), and the high-active mice over expressed proteins associated with metabolism (creatine kinase B, succinyl-CoA ligase).
Creatine kinase B is necessary to limit myoblast fusion during myogenesis.
New
Pavlath et al., Atlanta, United States. In Am J Physiol Cell Physiol, Jul 2015
Creatine kinase B (CKB), which replenishes local ATP pools, localizes near the ends of cultured primary mouse myotubes.
Proteomic analysis of cerebrospinal fluid in canine cervical spondylomyelopathy.
New
Green et al., Madrid, Spain. In Spine (phila Pa 1976), Jun 2015
Compared with the CSF of control dogs, CSM-affected dogs demonstrated increased CSF expression of 8 proteins including vitamin D-binding protein, gelsolin, creatine kinase B-type, angiotensinogen, α-2-HS-glycoprotein, SPARC (secreted protein, acidic, rich in cysteine), calsyntenin-1, and complement C3, and decreased expression of pigment epithelium-derived factor, prostaglandin-H2 D-isomerase, apolipoprotein E, and clusterin.
Label-free proteomics uncovers energy metabolism and focal adhesion regulations responsive for endometrium receptivity.
New
Xu et al., Shanghai, China. In J Proteome Res, May 2015
Direct protein-protein interaction network analyses of these significantly changed proteins showed that the up-regulation of creatine kinase B-type (CKB) in the receptive phase may be related to endometrium receptivity.
Extracellular metabolic energetics can promote cancer progression.
New
Impact
Tavazoie et al., New York City, United States. In Cell, Mar 2015
These miRNAs convergently target creatine kinase, brain-type (CKB), which phosphorylates the metabolite creatine, to generate phosphocreatine.
Submembranous recruitment of creatine kinase B supports formation of dynamic actin-based protrusions of macrophages and relies on its C-terminal flexible loop.
New
Wieringa et al., Nijmegen, Netherlands. In Eur J Cell Biol, Feb 2015
We have previously shown that brain-type creatine kinase (CK-B) accumulates at the phagocytic cup in macrophages where it is involved in the compartmentalized generation of ATP for actin remodeling.
Analysis of creatine kinase activity with evaluation of protein expression under the effect of heat and hydrogen peroxide.
New
Zoon et al., In Ukr Biochem J, Jan 2015
Protein oxidation has detrimental effects on the brain functioning, which involves inhibition of the crucial enzyme, brain type creatine kinase (CKBB), responsible for the CK/phosphocreatine shuttle system.
Cyanobacterial KnowledgeBase (CKB), a Compendium of Cyanobacterial Genomes and Proteomes.
New
Lakshmanan et al., Tiruchchirāppalli, India. In Plos One, Dec 2014
UNASSIGNED: Cyanobacterial KnowledgeBase (CKB) is a free access database that contains the genomic and proteomic information of 74 fully sequenced cyanobacterial genomes belonging to seven orders.
Neuronal toxicity of efavirenz: a systematic review.
Review
Maartens et al., Stellenbosch, South Africa. In Expert Opin Drug Saf, 2013
Several potential mechanisms exist to explain the observed efavirenz neurotoxicity, including altered calcium hemostasis, decreases in brain creatine kinase, mitochondrial damage, increases in brain proinflammatory cytokines and involvement of the cannabinoid system.
Energy dysfunction in Huntington's disease: insights from PGC-1α, AMPK, and CKB.
Review
Chern et al., Taipei, Taiwan. In Cell Mol Life Sci, 2012
This review focuses on the importance of three key molecular determinants (peroxisome proliferator-activated receptor-γ coactivator-1α, AMP-activated protein kinase, and creatine kinase B) of cellular energy homeostasis and their possible involvement in HD pathogenesis.
Crystal structure of Human ASB9-2 and substrate-recognition of CKB.
GeneRIF
Ji et al., Shanghai, China. In Protein J, 2012
His103 and Phe107 in hASB9-2 are essential for binding to CKB.
Involvement of creatine kinase B in cigarette smoke-induced bronchial epithelial cell senescence.
GeneRIF
Kuwano et al., Tokyo, Japan. In Am J Respir Cell Mol Biol, 2012
Cigarette smoke induced carbonylation and subsequent degradation of creatine kinase B are involved in the regulation of senescence in bronchial epithelial cells.
High levels of brain-type creatine kinase activity in human platelets and leukocytes: a genetic anomaly with autosomal dominant inheritance.
GeneRIF
Bugert et al., Freiburg, Germany. In Blood Cells Mol Dis, 2012
de-methylated CKB gene is inherited that leads to high CKB expression levels in myeloic precursor cells in the bone marrow
Besides Huntington's disease, does brain-type creatine kinase play a role in other forms of hearing impairment resulting from a common pathological cause?
Review
Chern et al., Taipei, Taiwan. In Aging (albany Ny), 2011
We also showed that dietary creatine supplementation rescued the impaired PCr-CK system and improved the expression of cochlear brain-type creatine kinase (CKB) in HD mice, thereby restoring their hearing.
Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington disease.
GeneRIF
Chern et al., Taipei, Taiwan. In J Clin Invest, 2011
reduced expression of brain creatine kinase in the cochlea of Huntington disease mice is associated with hearing impairment
Dissimilarity in the folding of human cytosolic creatine kinase isoenzymes.
GeneRIF
Yan et al., Beijing, China. In Plos One, 2010
The results suggested that the intra- and inter-subunit domain interactions modified the behavior of kinetic refolding.
Implications of efavirenz for neuropsychiatry: a review.
Review
Fonteles et al., Fortaleza, Brazil. In Int J Neurosci, 2010
The mechanisms involved in these changes include interference with cytochrome P450 enzymes, cytokines, tryptophan-2-3-dioxygenase, and brain creatine kinase.
Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption.
Impact
GeneRIF
Kim et al., Seoul, South Korea. In Nat Med, 2008
Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption.
Approaching the multifaceted nature of energy metabolism: inactivation of the cytosolic creatine kinases via homologous recombination in mouse embryonic stem cells.
Review
Wieringa et al., Nijmegen, Netherlands. In Mol Cell Biochem, 1994
Using targeting constructs based on strain 129/Sv isogenic DNA we managed to ablate the essential exons of the B-CK and M-CK genes at reasonably high frequencies.
Reversal of creatine kinase translational repression by 3' untranslated sequences.
Impact
Holmes et al., Durham, United States. In Science, 1990
A subline of U937 cells (U937D) was obtained in which creatine kinase B (CK-B) messenger RNA was present and bound to ribosomes, but CK activity was undetectable.
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