gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Mar 2015.

Creatine kinase, brain

CKB, brain creatine kinase, creatine kinase B, CKBB, B-CK
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, muscle creatine kinase, CAN, ACID, fibrillin-1
Papers on CKB
Extracellular metabolic energetics can promote cancer progression.
Tavazoie et al., New York City, United States. In Cell, 01 Mar 2015
These miRNAs convergently target creatine kinase, brain-type (CKB), which phosphorylates the metabolite creatine, to generate phosphocreatine.
Accelerated protein damage in brains of PIMT+/- mice; a possible model for the variability of cognitive decline in human aging.
Aswad et al., Irvine, United States. In Neurobiol Aging, 28 Feb 2015
To see if HZ mice exhibit accelerated aging at the molecular level, we compared brain extracts from HZ and WT mice at 8 months and 2 years with regard to PIMT activity, isoaspartate levels, and activity of an endogenous PIMT substrate, creatine kinase B. PIMT activity declined modestly with age in both genotypes.
Submembranous recruitment of creatine kinase B supports formation of dynamic actin-based protrusions of macrophages and relies on its C-terminal flexible loop.
Wieringa et al., Nijmegen, Netherlands. In Eur J Cell Biol, 28 Feb 2015
We have previously shown that brain-type creatine kinase (CK-B) accumulates at the phagocytic cup in macrophages where it is involved in the compartmentalized generation of ATP for actin remodeling.
Distinct protein signature of hypertension-induced damage in the renal proteome of the two-kidney, one-clip rat model.
Marti et al., Uppsala, Sweden. In J Hypertens, Jan 2015
Among the most significantly altered proteins in the whole cortex were periostin, transgelin, and creatine kinase B-type.
Identification of the responsible proteins for increased selenium bioavailability in the brain of transgenic rats overexpressing selenoprotein M.
Seong et al., Seoul, South Korea. In Int J Mol Med, Dec 2014
The results revealed that: ⅰ) CMV/hSelM Tg rats showed a high level of enzyme activity for antioxidant protein in the brain cortex compared to non-Tg rats; ⅱ) the high activity of these enzymes induced a decrease in total antioxidant concentration and γ-secretase activity in CMV/hSelM Tg rats; ⅲ) five proteins were upregulated and three were downregulated by SelM overexpression; ⅳ) among the five upregulated proteins, two associated with creatine kinase B-type (B-CK) and E3 ubiquitin-protein ligase RING1 (RING finger protein 1) were further increased in the two groups following Sel treatment, whereas synaptotagmin-15 (SytXV), eukaryotic translation initiation factor 4H (eIF-4H) and lactate dehydrogenase B (LDH-B) were increased or decreased under the same conditions; ⅴ) the three downregulated proteins did not induce a significant change in expression following Sel treatment; and ⅵ) the protein expression level alterations of the two selected spots (B-CK and SytXV) identified by 2-DE were extremely similar to the results from western blot analysis.
Proteomic analysis on infantile spasm and prenatal stress.
Zou et al., Beijing, China. In Epilepsy Res, Sep 2014
In the NS-spasm model vs. saline control, the main differentially expressed proteins were CFL1, PKM2, PRPS2, DLAT, CKB, DPYSL3, and SNAP25.
Isoaspartyl formation in creatine kinase B Is associated with loss of enzymatic activity; implications for the linkage of isoaspartate accumulation and neurological dysfunction in the PIMT knockout mouse.
Aswad et al., Irvine, United States. In Plos One, 2013
One of the major neuronal targets of PIMT is creatine kinase B (CKB), a well-characterized enzyme whose activity is relatively easy to assay.
Acute high-altitude hypoxic brain injury: Identification of ten differential proteins.
Zhang et al., Tianjin, China. In Neural Regen Res, 2013
These detected proteins included dihydropyrimidinase-related protein 2, creatine kinase B-type, isovaleryl-CoA dehydrogenase, elongation factor Ts, ATP synthase beta-subunit, 3-mercaptopyruvate sulfurtransferase, electron transfer flavoprotein alpha-subunit, Chain A of 2-enoyl-CoA hydratase, NADH dehydrogenase iron-sulfur protein 8 and tropomyosin beta chain.
Neuronal toxicity of efavirenz: a systematic review.
Maartens et al., Stellenbosch, South Africa. In Expert Opin Drug Saf, 2013
Several potential mechanisms exist to explain the observed efavirenz neurotoxicity, including altered calcium hemostasis, decreases in brain creatine kinase, mitochondrial damage, increases in brain proinflammatory cytokines and involvement of the cannabinoid system.
Energy dysfunction in Huntington's disease: insights from PGC-1α, AMPK, and CKB.
Chern et al., Taipei, Taiwan. In Cell Mol Life Sci, 2012
This review focuses on the importance of three key molecular determinants (peroxisome proliferator-activated receptor-γ coactivator-1α, AMP-activated protein kinase, and creatine kinase B) of cellular energy homeostasis and their possible involvement in HD pathogenesis.
Crystal structure of Human ASB9-2 and substrate-recognition of CKB.
Ji et al., Shanghai, China. In Protein J, 2012
His103 and Phe107 in hASB9-2 are essential for binding to CKB.
Involvement of creatine kinase B in cigarette smoke-induced bronchial epithelial cell senescence.
Kuwano et al., Tokyo, Japan. In Am J Respir Cell Mol Biol, 2012
Cigarette smoke induced carbonylation and subsequent degradation of creatine kinase B are involved in the regulation of senescence in bronchial epithelial cells.
High levels of brain-type creatine kinase activity in human platelets and leukocytes: a genetic anomaly with autosomal dominant inheritance.
Bugert et al., Freiburg, Germany. In Blood Cells Mol Dis, 2012
de-methylated CKB gene is inherited that leads to high CKB expression levels in myeloic precursor cells in the bone marrow
Besides Huntington's disease, does brain-type creatine kinase play a role in other forms of hearing impairment resulting from a common pathological cause?
Chern et al., Taipei, Taiwan. In Aging (albany Ny), 2011
We also showed that dietary creatine supplementation rescued the impaired PCr-CK system and improved the expression of cochlear brain-type creatine kinase (CKB) in HD mice, thereby restoring their hearing.
Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington disease.
Chern et al., Taipei, Taiwan. In J Clin Invest, 2011
reduced expression of brain creatine kinase in the cochlea of Huntington disease mice is associated with hearing impairment
Dissimilarity in the folding of human cytosolic creatine kinase isoenzymes.
Yan et al., Beijing, China. In Plos One, 2010
The results suggested that the intra- and inter-subunit domain interactions modified the behavior of kinetic refolding.
Implications of efavirenz for neuropsychiatry: a review.
Fonteles et al., Fortaleza, Brazil. In Int J Neurosci, 2010
The mechanisms involved in these changes include interference with cytochrome P450 enzymes, cytokines, tryptophan-2-3-dioxygenase, and brain creatine kinase.
Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption.
Kim et al., Seoul, South Korea. In Nat Med, 2008
Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption.
Approaching the multifaceted nature of energy metabolism: inactivation of the cytosolic creatine kinases via homologous recombination in mouse embryonic stem cells.
Wieringa et al., Nijmegen, Netherlands. In Mol Cell Biochem, 1994
Using targeting constructs based on strain 129/Sv isogenic DNA we managed to ablate the essential exons of the B-CK and M-CK genes at reasonably high frequencies.
Reversal of creatine kinase translational repression by 3' untranslated sequences.
Holmes et al., Durham, United States. In Science, 1990
A subline of U937 cells (U937D) was obtained in which creatine kinase B (CK-B) messenger RNA was present and bound to ribosomes, but CK activity was undetectable.
share on facebooktweetadd +1mail to friends