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Creatine kinase, brain

CKB, brain creatine kinase, creatine kinase B, CKBB, B-CK
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, muscle creatine kinase, CAN, ACID, fibrillin-1
Papers on CKB
In vivo (1) H MRS and (31) P MRSI of the response to cyclocreatine in transgenic mouse liver expressing creatine kinase.
Branch et al., United States. In Nmr Biomed, 09 Nov 2015
We examine the possibility of using the Cr analog cyclocreatine (CCr, a substrate for CK), which is quickly phosphorylated to phosphocyclocreatine (PCCr), as a higher SNR alternative to Cr. (1) H MRS and (31) P MRSI were employed to measure the effect of incremental supplementation of CCr upon PCCr, γ-ATP, pH and Pi /ATP in the liver of transgenic mice expressing the BB isoform of CK (CKBB ) in hepatocytes.
Differential protein expression in the nucleus accumbens of high and low active mice.
Lightfoot et al., Houston, United States. In Behav Brain Res, 15 Oct 2015
Low active mice generally over expressed proteins associated with neural stress (Stress 70 protein and V type proton ATPase catalytic subunit A), and the high-active mice over expressed proteins associated with metabolism (creatine kinase B, succinyl-CoA ligase).
Proteomic Analysis of Protein Expression Throughout Disease Progression in a Mouse Model of Alzheimer's Disease.
Yang et al., Beijing, China. In J Alzheimers Dis, Sep 2015
Among those, the expression levels of the following proteins in AβPPswe/PS1dE9 mice were at least 1.5 times higher than those in normal mice: DCC-interacting protein 13-beta, serum albumin, creatine kinase B-type, heat shock 70 kDa protein 1A, T-complex protein 1 subunit beta, adenylate kinase isoenzyme 1, pyruvate dehydrogenase E1 component subunit beta mitochondrial, and V-type proton ATPase catalytic subunit A. Levels of the following proteins in AβPPswe/PS1dE9 mice were at least 1.5 times lower than those in normal mice: dihydropyrimidinase-related protein 2, actin cytoplasmic 2, isoform 1 of V-type proton ATPase catalytic subunit, tubulin alpha-1C chain, F-actin-capping protein subunit alpha-2, ubiquitin carboxyl-terminal hydrolase isozyme L1, and actin cytoplasmic 1.
Proteomic analysis of cerebrospinal fluid in canine cervical spondylomyelopathy.
Green et al., Madrid, Spain. In Spine (phila Pa 1976), Jun 2015
Compared with the CSF of control dogs, CSM-affected dogs demonstrated increased CSF expression of 8 proteins including vitamin D-binding protein, gelsolin, creatine kinase B-type, angiotensinogen, α-2-HS-glycoprotein, SPARC (secreted protein, acidic, rich in cysteine), calsyntenin-1, and complement C3, and decreased expression of pigment epithelium-derived factor, prostaglandin-H2 D-isomerase, apolipoprotein E, and clusterin.
Extracellular metabolic energetics can promote cancer progression.
Tavazoie et al., New York City, United States. In Cell, Mar 2015
These miRNAs convergently target creatine kinase, brain-type (CKB), which phosphorylates the metabolite creatine, to generate phosphocreatine.
Analysis of creatine kinase activity with evaluation of protein expression under the effect of heat and hydrogen peroxide.
Zoon et al., In Ukr Biochem J, Jan 2015
Protein oxidation has detrimental effects on the brain functioning, which involves inhibition of the crucial enzyme, brain type creatine kinase (CKBB), responsible for the CK/phosphocreatine shuttle system.
Cyanobacterial KnowledgeBase (CKB), a Compendium of Cyanobacterial Genomes and Proteomes.
Lakshmanan et al., Tiruchchirāppalli, India. In Plos One, Dec 2014
Cyanobacterial KnowledgeBase (CKB) is a free access database that contains the genomic and proteomic information of 74 fully sequenced cyanobacterial genomes belonging to seven orders.
Deregulated Expression of SRC, LYN and CKB Kinases by DNA Methylation and Its Potential Role in Gastric Cancer Invasiveness and Metastasis.
Burbano et al., Campina Grande, Brazil. In Plos One, Dec 2014
In this study, we aimed to evaluate SRC, LYN and CKB protein and mRNA expression, as well as their promoter methylation, in gastric cancer.
Neuronal toxicity of efavirenz: a systematic review.
Maartens et al., Stellenbosch, South Africa. In Expert Opin Drug Saf, 2013
Several potential mechanisms exist to explain the observed efavirenz neurotoxicity, including altered calcium hemostasis, decreases in brain creatine kinase, mitochondrial damage, increases in brain proinflammatory cytokines and involvement of the cannabinoid system.
Energy dysfunction in Huntington's disease: insights from PGC-1α, AMPK, and CKB.
Chern et al., Taipei, Taiwan. In Cell Mol Life Sci, 2012
This review focuses on the importance of three key molecular determinants (peroxisome proliferator-activated receptor-γ coactivator-1α, AMP-activated protein kinase, and creatine kinase B) of cellular energy homeostasis and their possible involvement in HD pathogenesis.
Crystal structure of Human ASB9-2 and substrate-recognition of CKB.
Ji et al., Shanghai, China. In Protein J, 2012
His103 and Phe107 in hASB9-2 are essential for binding to CKB.
Involvement of creatine kinase B in cigarette smoke-induced bronchial epithelial cell senescence.
Kuwano et al., Tokyo, Japan. In Am J Respir Cell Mol Biol, 2012
Cigarette smoke induced carbonylation and subsequent degradation of creatine kinase B are involved in the regulation of senescence in bronchial epithelial cells.
High levels of brain-type creatine kinase activity in human platelets and leukocytes: a genetic anomaly with autosomal dominant inheritance.
Bugert et al., Freiburg, Germany. In Blood Cells Mol Dis, 2012
de-methylated CKB gene is inherited that leads to high CKB expression levels in myeloic precursor cells in the bone marrow
Besides Huntington's disease, does brain-type creatine kinase play a role in other forms of hearing impairment resulting from a common pathological cause?
Chern et al., Taipei, Taiwan. In Aging (albany Ny), 2011
We also showed that dietary creatine supplementation rescued the impaired PCr-CK system and improved the expression of cochlear brain-type creatine kinase (CKB) in HD mice, thereby restoring their hearing.
Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington disease.
Chern et al., Taipei, Taiwan. In J Clin Invest, 2011
reduced expression of brain creatine kinase in the cochlea of Huntington disease mice is associated with hearing impairment
Dissimilarity in the folding of human cytosolic creatine kinase isoenzymes.
Yan et al., Beijing, China. In Plos One, 2010
The results suggested that the intra- and inter-subunit domain interactions modified the behavior of kinetic refolding.
Implications of efavirenz for neuropsychiatry: a review.
Fonteles et al., Fortaleza, Brazil. In Int J Neurosci, 2010
The mechanisms involved in these changes include interference with cytochrome P450 enzymes, cytokines, tryptophan-2-3-dioxygenase, and brain creatine kinase.
Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption.
Kim et al., Seoul, South Korea. In Nat Med, 2008
Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption.
Approaching the multifaceted nature of energy metabolism: inactivation of the cytosolic creatine kinases via homologous recombination in mouse embryonic stem cells.
Wieringa et al., Nijmegen, Netherlands. In Mol Cell Biochem, 1994
Using targeting constructs based on strain 129/Sv isogenic DNA we managed to ablate the essential exons of the B-CK and M-CK genes at reasonably high frequencies.
Reversal of creatine kinase translational repression by 3' untranslated sequences.
Holmes et al., Durham, United States. In Science, 1990
A subline of U937 cells (U937D) was obtained in which creatine kinase B (CK-B) messenger RNA was present and bound to ribosomes, but CK activity was undetectable.
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