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Creatine kinase, brain

CKB, brain creatine kinase, creatine kinase B, CKBB, B-CK
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, muscle creatine kinase, CAN, ACID, fibrillin-1
Papers on CKB
Proteomic Changes in Female Rat Hippocampus Following Exposure to a Terrified Sound Stress.
New
Huang et al., Xi'an, China. In J Mol Neurosci, 09 Mar 2014
The seven most differentially expressed proteins were identified and validated as follows: dihydropyrimidinase-related protein 2 (DRP-2), creatine kinase B type, dynamin-1 protein, alpha-internexin, glial fibrillary acidic protein beta, gamma-enolase, and peptidyl-prolyl cis-trans isomerase A. Changes in protein levels were detected in the hippocampus of female rats subjected to terrified sound stress.
Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas.
New
Morgan et al., Exeter, United Kingdom. In Diabetologia, 28 Feb 2014
Recent data suggest that the clone 5D8/1 may also recognise non-viral antigens; in particular, a component of the mitochondrial ATP synthase (ATP5B) and an isoform of creatine kinase (CKB).
Resistance artery creatine kinase mRNA and blood pressure in humans.
New
Brewster et al., Amsterdam, Netherlands. In Hypertension, Jan 2014
Normalized creatine kinase B mRNA copy numbers, ranging from 5.2 to 24.4 (mean, 15.0; SE, 1.9), showed a near-perfect correlation with diastolic blood pressure (correlation coefficient, 0.9; 95% confidence interval, 0.6-1.0)
Proteomic analysis of post-nuclear supernatant fraction and percoll-purified membranes prepared from brain cortex of rats exposed to increasing doses of morphine.
New
Svoboda et al., Praha, Czech Republic. In Proteome Sci, Dec 2013
RESULTS: In PNS, the 10 up (↑)- or down (↓)-regulated proteins exhibiting the largest morphine-induced change were selected, excised manually from the gel and identified by MALDI-TOF MS/MS: 1-(gi|148747414, Guanine deaminase), ↑2.5×; 2-(gi|17105370, Vacuolar-type proton ATP subunit B, brain isoform), ↑2.6×; 3-(gi|1352384, Protein disulfide-isomerase A3), ↑3.4×; 4-(gi|40254595, Dihydropyrimidinase-related protein 2), ↑3.6×; 5-(gi|149054470, N-ethylmaleimide sensitive fusion protein, isoform CRAa), ↑2.0×; 6-(gi|42476181, Malate dehydrogenase, mitochondrial precursor), ↑1.4×; 7-(gi|62653546, Glyceraldehyde-3-phosphate dehydrogenase), ↑1.6×; 8-(gi|202837, Aldolase A), ↑1.3×; 9-(gi|31542401, Creatine kinase B-type), ↓0.86×; 10-(gi|40538860, Aconitate hydratase, mitochondrial precursor), ↑1.3×.
Chronic hypoxia enhances expression and activity of mitochondrial creatine kinase and hexokinase in the rat ventricular myocardium.
New
Zurmanova et al., Praha, Czech Republic. In Cell Physiol Biochem, Dec 2013
Results: CK and HK activities increased in the LV during all hypoxic adaptations, which was consistent with elevated protein levels of mitochondrial mtCKs, cytosolic CKB, HK1, and HK2 isoforms.
Neuronal toxicity of efavirenz: a systematic review.
New
Maartens et al., Stellenbosch, South Africa. In Expert Opin Drug Saf, Nov 2013
Several potential mechanisms exist to explain the observed efavirenz neurotoxicity, including altered calcium hemostasis, decreases in brain creatine kinase, mitochondrial damage, increases in brain proinflammatory cytokines and involvement of the cannabinoid system.
Quantitative proteomics analysis of varicose veins: identification of a set of differentially expressed proteins related to ATP generation and utilization.
New
Lin et al., Kao-hsiung, Taiwan. In Kaohsiung J Med Sci, Nov 2013
Stable isotope dimethyl labeling coupled with nanoLC-MS/MS revealed downregulation in 12 polypeptides, including myosin light chain kinase, creatine kinase B-type, ATP synthase, phosphoglycerate kinase, and pyruvate kinase.
Proteomic analysis of time-dependent changes in proteins expressed in mouse hippocampus during synaptic plasticity induced by GABAA receptor blockade.
New
Matsuyama et al., Himeji, Japan. In Neurosci Lett, Nov 2013
Expression of 14 proteins (i.e., dihydropyrimidinase-related protein 2, α-tubulin isotype M-α-2, tubulin β-1 chain, tubulin β-2A chain, protein disulfide-isomerase ERp61 precursor, chaperonin-containing T complex polypeptide 1 β subunit, T complex polypeptide 1 [partial], creatine kinase B-type, cytosolic malate dehydrogenase [partial], vacuolar adenosine triphosphatase subunit A, and uncharacterized protein LOC433182) was increased and expression of one protein (i.e., actin γ, cytoplasmic 1) was decreased.
Energy dysfunction in Huntington's disease: insights from PGC-1α, AMPK, and CKB.
Review
Chern et al., Taipei, Taiwan. In Cell Mol Life Sci, 2012
This review focuses on the importance of three key molecular determinants (peroxisome proliferator-activated receptor-γ coactivator-1α, AMP-activated protein kinase, and creatine kinase B) of cellular energy homeostasis and their possible involvement in HD pathogenesis.
Crystal structure of Human ASB9-2 and substrate-recognition of CKB.
GeneRIF
Ji et al., Shanghai, China. In Protein J, 2012
His103 and Phe107 in hASB9-2 are essential for binding to CKB.
Involvement of creatine kinase B in cigarette smoke-induced bronchial epithelial cell senescence.
GeneRIF
Kuwano et al., Tokyo, Japan. In Am J Respir Cell Mol Biol, 2012
Cigarette smoke induced carbonylation and subsequent degradation of creatine kinase B are involved in the regulation of senescence in bronchial epithelial cells.
High levels of brain-type creatine kinase activity in human platelets and leukocytes: a genetic anomaly with autosomal dominant inheritance.
GeneRIF
Bugert et al., Freiburg, Germany. In Blood Cells Mol Dis, 2012
de-methylated CKB gene is inherited that leads to high CKB expression levels in myeloic precursor cells in the bone marrow
Besides Huntington's disease, does brain-type creatine kinase play a role in other forms of hearing impairment resulting from a common pathological cause?
Review
Chern et al., Taipei, Taiwan. In Aging (albany Ny), 2011
We also showed that dietary creatine supplementation rescued the impaired PCr-CK system and improved the expression of cochlear brain-type creatine kinase (CKB) in HD mice, thereby restoring their hearing.
Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington disease.
GeneRIF
Chern et al., Taipei, Taiwan. In J Clin Invest, 2011
reduced expression of brain creatine kinase in the cochlea of Huntington disease mice is associated with hearing impairment
Dissimilarity in the folding of human cytosolic creatine kinase isoenzymes.
GeneRIF
Yan et al., Beijing, China. In Plos One, 2010
The results suggested that the intra- and inter-subunit domain interactions modified the behavior of kinetic refolding.
Implications of efavirenz for neuropsychiatry: a review.
Review
Fonteles et al., Fortaleza, Brazil. In Int J Neurosci, 2010
The mechanisms involved in these changes include interference with cytochrome P450 enzymes, cytokines, tryptophan-2-3-dioxygenase, and brain creatine kinase.
Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption.
Impact
GeneRIF
Kim et al., Seoul, South Korea. In Nat Med, 2008
Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption.
Approaching the multifaceted nature of energy metabolism: inactivation of the cytosolic creatine kinases via homologous recombination in mouse embryonic stem cells.
Review
Wieringa et al., Nijmegen, Netherlands. In Mol Cell Biochem, 1994
Using targeting constructs based on strain 129/Sv isogenic DNA we managed to ablate the essential exons of the B-CK and M-CK genes at reasonably high frequencies.
Sequence homology and structure predictions of the creatine kinase isoenzymes.
Review
Wyss et al., Zürich, Switzerland. In Mol Cell Biochem, 1994
A 'CK framework' is defined, consisting of the most conserved sequence blocks, and 'diagnostic boxes' are identified which are characteristic for anyone creatine kinase isoenzyme (e.g. for vertebrate B-CK) and which may serve to distinguish this isoenzyme from all others (e.g. from M-CKs and Mi-CKs).
Reversal of creatine kinase translational repression by 3' untranslated sequences.
Impact
Holmes et al., Durham, United States. In Science, 1990
A subline of U937 cells (U937D) was obtained in which creatine kinase B (CK-B) messenger RNA was present and bound to ribosomes, but CK activity was undetectable.
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