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Creatine kinase, brain

CKB, brain creatine kinase, creatine kinase B, CKBB, B-CK
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: muscle creatine kinase, HAD, CAN, ACID, fibrillin-1
Papers on CKB
Identification of the responsible proteins for increased selenium bioavailability in the brain of transgenic rats overexpressing selenoprotein M.
New
Seong et al., Seoul, South Korea. In Int J Mol Med, 31 Dec 2014
The results revealed that: ⅰ) CMV/hSelM Tg rats showed a high level of enzyme activity for antioxidant protein in the brain cortex compared to non‑Tg rats; ⅱ) the high activity of these enzymes induced a decrease in total antioxidant concentration and γ‑secretase activity in CMV/hSelM Tg rats; ⅲ) five proteins were upregulated and three were downregulated by SelM overexpression; ⅳ) among the five upregulated proteins, two associated with creatine kinase B‑type (B‑CK) and E3 ubiquitin‑protein ligase RING1 (RING finger protein 1) were further increased in the two groups following Sel treatment, whereas synaptotagmin-15 (SytXV), eukaryotic translation initiation factor 4H (eIF-4H) and lactate dehydrogenase B (LDH-B) were increased or decreased under the same conditions; ⅴ) the three downregulated proteins did not induce a significant change in expression following Sel treatment; and ⅵ) the protein expression level alterations of the two selected spots (B‑CK and SytXV) identified by 2‑DE were extremely similar to the results from western blot analysis.
Distinct protein signature of hypertension-induced damage in the renal proteome of the two-kidney, one-clip rat model.
New
Marti et al., Uppsala, Sweden. In J Hypertens, 09 Nov 2014
Among the most significantly altered proteins in the whole cortex were periostin, transgelin, and creatine kinase B-type.
Proteomic analysis on infantile spasm and prenatal stress.
New
Zou et al., Beijing, China. In Epilepsy Res, Sep 2014
In the NS-spasm model vs. saline control, the main differentially expressed proteins were CFL1, PKM2, PRPS2, DLAT, CKB, DPYSL3, and SNAP25.
Targeted quantitative analysis of synaptic proteins in Alzheimer's disease brain.
New
Nouwens et al., Australia. In Neurochem Int, Sep 2014
Significantly lower levels of peroxiredoxin-1 and the energy-related enzymes creatine kinase B and fructose-bisphosphate aldolase C were found in non-AD hippocampus.
[Proteomic study of the hippocampus tissue from rats with chronic Toxoplasma gondii infection].
New
Gao et al., In Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi, Dec 2013
The 9 differentially expressed protein spots were identified by MALDL-TOF-MS: phosphoglycerate kinase 1, similar to alpha-enolase, glutamine synthetase, creatine kinase, creatine kinase B-type, ATP synthase, aconitase 2, mitochondrial precursor, actin and an unnamed protein.
In vivo substrates of the lens molecular chaperones αA-crystallin and αB-crystallin.
New
Townsend et al., Saint Louis, United States. In Plos One, Dec 2013
Compared with age-matched wild type lenses, 2-day-old αA-R49C heterozygous lenses demonstrated the following: increased crosslinking (15-fold) and degradation (2.6-fold) of αA-crystallin; increased association between αA-crystallin and filensin, actin, or creatine kinase B; increased acidification of βB1-crystallin; increased levels of grifin; and an association between βA3/A1-crystallin and αA-crystallin.
Isoaspartyl formation in creatine kinase B Is associated with loss of enzymatic activity; implications for the linkage of isoaspartate accumulation and neurological dysfunction in the PIMT knockout mouse.
New
Aswad et al., Irvine, United States. In Plos One, Dec 2013
One of the major neuronal targets of PIMT is creatine kinase B (CKB), a well-characterized enzyme whose activity is relatively easy to assay.
Acute high-altitude hypoxic brain injury: Identification of ten differential proteins.
New
Zhang et al., Tianjin, China. In Neural Regen Res, Dec 2013
These detected proteins included dihydropyrimidinase-related protein 2, creatine kinase B-type, isovaleryl-CoA dehydrogenase, elongation factor Ts, ATP synthase beta-subunit, 3-mercaptopyruvate sulfurtransferase, electron transfer flavoprotein alpha-subunit, Chain A of 2-enoyl-CoA hydratase, NADH dehydrogenase iron-sulfur protein 8 and tropomyosin beta chain.
Neuronal toxicity of efavirenz: a systematic review.
Review
New
Maartens et al., Stellenbosch, South Africa. In Expert Opin Drug Saf, Nov 2013
Several potential mechanisms exist to explain the observed efavirenz neurotoxicity, including altered calcium hemostasis, decreases in brain creatine kinase, mitochondrial damage, increases in brain proinflammatory cytokines and involvement of the cannabinoid system.
Energy dysfunction in Huntington's disease: insights from PGC-1α, AMPK, and CKB.
Review
Chern et al., Taipei, Taiwan. In Cell Mol Life Sci, 2012
This review focuses on the importance of three key molecular determinants (peroxisome proliferator-activated receptor-γ coactivator-1α, AMP-activated protein kinase, and creatine kinase B) of cellular energy homeostasis and their possible involvement in HD pathogenesis.
Crystal structure of Human ASB9-2 and substrate-recognition of CKB.
GeneRIF
Ji et al., Shanghai, China. In Protein J, 2012
His103 and Phe107 in hASB9-2 are essential for binding to CKB.
Involvement of creatine kinase B in cigarette smoke-induced bronchial epithelial cell senescence.
GeneRIF
Kuwano et al., Tokyo, Japan. In Am J Respir Cell Mol Biol, 2012
Cigarette smoke induced carbonylation and subsequent degradation of creatine kinase B are involved in the regulation of senescence in bronchial epithelial cells.
High levels of brain-type creatine kinase activity in human platelets and leukocytes: a genetic anomaly with autosomal dominant inheritance.
GeneRIF
Bugert et al., Freiburg, Germany. In Blood Cells Mol Dis, 2012
de-methylated CKB gene is inherited that leads to high CKB expression levels in myeloic precursor cells in the bone marrow
Besides Huntington's disease, does brain-type creatine kinase play a role in other forms of hearing impairment resulting from a common pathological cause?
Review
Chern et al., Taipei, Taiwan. In Aging (albany Ny), 2011
We also showed that dietary creatine supplementation rescued the impaired PCr-CK system and improved the expression of cochlear brain-type creatine kinase (CKB) in HD mice, thereby restoring their hearing.
Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington disease.
GeneRIF
Chern et al., Taipei, Taiwan. In J Clin Invest, 2011
reduced expression of brain creatine kinase in the cochlea of Huntington disease mice is associated with hearing impairment
Dissimilarity in the folding of human cytosolic creatine kinase isoenzymes.
GeneRIF
Yan et al., Beijing, China. In Plos One, 2010
The results suggested that the intra- and inter-subunit domain interactions modified the behavior of kinetic refolding.
Implications of efavirenz for neuropsychiatry: a review.
Review
Fonteles et al., Fortaleza, Brazil. In Int J Neurosci, 2010
The mechanisms involved in these changes include interference with cytochrome P450 enzymes, cytokines, tryptophan-2-3-dioxygenase, and brain creatine kinase.
Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption.
Impact
GeneRIF
Kim et al., Seoul, South Korea. In Nat Med, 2008
Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption.
Approaching the multifaceted nature of energy metabolism: inactivation of the cytosolic creatine kinases via homologous recombination in mouse embryonic stem cells.
Review
Wieringa et al., Nijmegen, Netherlands. In Mol Cell Biochem, 1994
Using targeting constructs based on strain 129/Sv isogenic DNA we managed to ablate the essential exons of the B-CK and M-CK genes at reasonably high frequencies.
Reversal of creatine kinase translational repression by 3' untranslated sequences.
Impact
Holmes et al., Durham, United States. In Science, 1990
A subline of U937 cells (U937D) was obtained in which creatine kinase B (CK-B) messenger RNA was present and bound to ribosomes, but CK activity was undetectable.
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