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Keratin 7

CK7, cytokeratin 7, Scl, Keratin-7, transaldolase, TAL1
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: cytokeratin, CD20, HAD, CAN, vimentin
Papers using CK7 antibodies
A role for the juxtamembrane cytoplasm in the molecular dynamics of focal adhesions.
Parsons Maddy, In PLoS ONE, 2008
... (clone 9E10; Developmental Studies Hybridoma Bank at the University of Iowa, Iowa City, IA); goat anti-transaldolase (Santa Cruz Biotechnology); mouse anti-β1 integrin (BD ...
Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients
Richardson Andrea L et al., In Breast Cancer Research : BCR, 2008
... the TMAs were immunostained for cytokeratin (CK) 5/6 (D5/16B4 antibody, Dako), CK14 (LL02 antibody, Neomarkers), CK7/8 (Cam5.2
Differential diagnosis of primary versus metastatic pulmonary adenocarcinomas using gene mutation analyses: a case report
Allan Robert W. et al., In Case Reports in Pathology, 2007
These included thyroid transcription factor-1 (TTF-1, 8G7G3/1 clone, Cell Marque, Rocklin, CA, USA), cytokeratin 7 (OV-TL clone, Dako, Carpinteria, CA, USA), and ...
A case of primary small cell carcinoma of the breast
Bergkvist Leif et al., In Pathology Research International, 2006
... (CK; Dako, clone 34BE12, 1 : 150), CK8/18 (Novocastra, clone 5D3, 1 : 50), CK20 (Dako, clone Ks20.8, 1 : 100), CK7 (Dako, clone OVTL 12/30, 1 : 200), ...
MUC gene expression and histogenesis of adenocarcinoma of the stomach
Yano Seiji et al., In Diagnostic Pathology, 2000
... including carcinoma tissues, were stained immunohistochemically with the following antibody panel: monoclonal antibodies to cytokeratin 7 (CK7, OV-TL12/30, dilution 1:100; Dako Cytomation, Carpinteria, CA), cytokeratin ...
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Papers on CK7
Disruption of PHO13 improves ethanol production via the xylose isomerase pathway.
Kondo et al., Kōbe, Japan. In Amb Express, 31 Dec 2016
Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YΔGP/XK/XI strain.
Immunohistochemistry of ductal adenocarcinoma of the prostate and adenocarcinomas of non-prostatic origin: a comparative study.
Egevad et al., Stockholm, Sweden. In Apmis, Feb 2016
Slides were stained for estrogen, progesterone and androgen receptor, prolactin, PSA, prostein, PSMA, PSAP, CDX2, lysozyme, villin, monoclonal CEA, CK7, CK20, HMWCK, p63, p504s, c-Myc, EGFR, Ki-67, p16, p21, p27, p53, PTEN, ERG, and PAX-8.
Rictor is required for optimal bone accrual in response to anti-sclerostin therapy in the mouse.
Long et al., Nanjing, China. In Bone, Feb 2016
Neutralizing antibodies against the secreted Wnt antagonist sclerostin (Scl-Ab) increase bone mass in both animal models and humans.
Small Cell Carcinoma of the Urinary Bladder: KIT and PDGFRA Gene Mutations.
Kozacioğlu et al., İzmir, Turkey. In Rare Tumors, Jan 2016
The tumor cells were negative for CK7, CK20, CD3, CD20, LCA, CDX2, uroplakin, thyroid transcription factor 1, PSA and p63.
Thyroid-like follicular carcinoma of the kidney: one case report and review of the literature.
Nodit et al., Pittsburgh, United States. In Am J Clin Pathol, Nov 2015
The tumor cells strongly expressed CK7, PAX-8, PAX-2, vimentin, EMA, and CK19 immunostains.
A collision tumor of papillary renal cell carcinoma and oncocytoma: case report and literature review.
Giannico et al., Nashville, United States. In Am J Clin Pathol, Nov 2015
By immunohistochemistry, focal CK7 expression was present in the oncocytoma, while strong diffuse positive CK7 expression was present in the PRCC component.
The search for cis-regulatory driver mutations in cancer genomes.
Wong et al., Sydney, Australia. In Oncotarget, Nov 2015
The recent discoveries of recurrent TERT promoter mutations in melanoma, and recurrent mutations that create a super-enhancer regulating TAL1 expression in T-cell acute lymphoblastic leukaemia (T-ALL), have sparked significant interest in the search for other somatic cis-regulatory mutations driving cancer development.
Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour.
Pelkmans et al., Zürich, Switzerland. In Nature, Aug 2015
In cells experiencing low crowding, FAK suppresses transcription of the ABC transporter A1 (ABCA1) by inhibiting FOXO3 and TAL1.
Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy.
Sang et al., Nanjing, China. In An Bras Dermatol, May 2015
They were stained positive for villin, CDX-2, CKpan (AE1/ AE3), CEA, CK8/18, CK19, CK7, EMA, Ki-67 (50%), and negative for S-100, CK20, CD34, GCDFP-15 and TTF-1.
Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.
Look et al., Boston, United States. In Science, 2015
In a subset of T-cell acute lymphoblastic leukemia (T-ALL) cases, we found that heterozygous somatic mutations are acquired that introduce binding motifs for the MYB transcription factor in a precise noncoding site, which creates a super-enhancer upstream of the TAL1 oncogene.
Cryptococcal infection of the femoral bone similar with pathologic features of vascular tumors: a case report and review of literature.
Jiang et al., Guangzhou, China. In Int J Clin Exp Pathol, 2014
By immunohistochemistry (IHC), only CD31 and CD68 were positive, while CK, CK8/18, EMA, P63, CK7, CK20, PSAP, PSA, CD34 negative.
Numerous osteoclast-like giant cells in metastases from lung adenocarcinoma, but absent from primary tumor.
Sato et al., Tokyo, Japan. In Thorac Cancer, 2014
Primary lung carcinoma cells were positive for cytokeratin 7 (CK7), epithelial membrane antigen (EMA), thyroid transcription factor 1 (TTF-1), and Napsin A, but were negative for vimentin and CD68.
Trichostatin A enhances vascular repair by injected human endothelial progenitors through increasing the expression of TAL1-dependent genes.
Brand et al., Ottawa, Canada. In Cell Stem Cell, 2014
Here, we identify the transcription factor TAL1/SCL as a key mediator of the vascular repair function of primary human endothelial colony-forming cells (ECFCs).
Targeting epigenetics to speed up repair.
Grosveld et al., Fontenay-aux-Roses, France. In Cell Stem Cell, 2014
reveal that TAL1 is a master regulator of adhesion and migration networks in human endothelial progenitors and that ex vivo treatment with the histone deacetylase inhibitor TSA enables their faster vascularization after ischemic injury.
Mesp1 patterns mesoderm into cardiac, hematopoietic, or skeletal myogenic progenitors in a context-dependent manner.
Kyba et al., Minneapolis, United States. In Cell Stem Cell, 2013
Remarkably, instead of promoting cardiac differentiation in the initial wave of mesoderm, Mesp1 binds to the Tal1 (Scl) +40 kb enhancer and generates Flk-1+ precursors expressing Etv2 (ER71) and Tal1 that undergo hematopoietic differentiation.
GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (Sirt1).
Noguchi et al., Bethesda, United States. In J Biol Chem, 2012
a novel role for GATA-4 and TAL1 to affect skeletal myogenic differentiation and EPO response via cross-talk with Sirt1.
Histomorphologic and molecular features of pouch and peripouch adenocarcinoma: a comparison with ulcerative colitis-associated adenocarcinoma.
Liu et al., Cleveland, United States. In Am J Surg Pathol, 2012
Pouch/peripouch and UC-associated adenocarcinoma had a comparable positive rate for CK7, CK20, and CDX2 by immunohistochemistry.
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.
Look et al., Boston, United States. In Cancer Cell, 2012
TAL1 forms a positive interconnected autoregulatory loop with GATA3 and RUNX1 and that the TAL1 complex directly activates the MYB oncogene.
Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium.
Mikkola et al., Los Angeles, United States. In Cell, 2012
Studies revealed an unexpected repressive role for Scl, as loss of Scl resulted in the generation of ectopic cardiomyocytes in yolk sac vasculature and the endocardium; these results uncover remarkable developmental plasticity in embryonic vasculature and identify Scl as a key determinant of endothelial fate choice.
Characterization of non-oxidative transaldolase and transketolase enzymes in the pentose phosphate pathway with regard to xylose utilization by recombinant Saccharomyces cerevisiae.
Yano et al., Hiroshima, Japan. In Enzyme Microb Technol, 2012
characterization of NQM1 and TKL2, together with TAL1 and TKL1, regarding their roles in xylose utilization and fermentation
More papers using CK7 antibodies
Radioimmunoassys for IGFs and IGFBPs.
Aplin John D et al., In BMC Developmental Biology, 1993
... Monoclonal anti-cytokeratin 7 was from Dako (Ely, UK) ...
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