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Keratin 13

CK13, keratin 13, cytokeratin 13
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: cytokeratin, CAN, cytokeratin 19, K14, cytokeratin 18
Papers on CK13
Ex vivo construction of a novel model of bioengineered bladder mucosa: A preliminary study.
New
Garzón et al., Granada, Spain. In Int J Urol, Jan 2016
After 7 days of ex vivo development, the epithelial layer expressed pancytokeratin, and cytokeratins CK7, CK8 and CK13, as well as filaggrin and ZO-2, with negative expression of CK4 and uroplakin III.
A Rare Urachal Cyst in a Case of Ketamine-Induced Cystitis Provides Mechanistic Insights.
New
Baker et al., York, United Kingdom. In Urology, Jan 2016
Evidence of widespread cytokeratin 13, basal p75(NTR), and sparse superficial uroplakin 3a immunoreactivity suggested the urachal epithelium was fundamentally transitional in nature.
Immunohistochemical Characterization of the Ectopic Epithelium Devoid of Goblet Cells From a Posttraumatic Iris Cyst Causing Mucogenic Glaucoma.
New
Sugiyama et al., Kyoto, Japan. In J Glaucoma, Dec 2015
Ectopic epithelial cells were abundantly positive for CK15, a limbal basal cell marker, but there was patchy immunostaining of CK13, a conjunctival epithelial marker, and sparse labeling with CK12, a corneal epithelial marker.
Identification of distinct layers within the stratified squamous epithelium of the adult human true vocal fold.
New
Rajagopal et al., Cambridge, United States. In Laryngoscope, Sep 2015
METHODS: Histologic sections of normal human laryngeal tissue were analyzed for morphology (hematoxylin and eosin) and immunohistochemical protein expression profile, including cytokeratins (CK13 and CK14), cornified envelope proteins (involucrin), basal cells (NGFR/p75), and proliferation markers (Ki67).
Loss of cytokeratin 10 indicates malignant transformation in actinic cheilitis.
New
Soares et al., Bauru, Brazil. In Clin Oral Investig, Sep 2015
OBJECTIVES: The aim of this study was to investigate the relationship the expression of cytokeratins (CK10 and CK13) and the cell proliferation index determined by Ki-67 of lip squamous cell carcinoma and actinic cheilitis with different degrees of dysplasia.
Differential Expression of Cytokeratin 13 in Non-Neoplastic, Dysplastic and Neoplastic Oral Mucosa in a High Risk Pakistani Population.
Pervez et al., Karāchi, Pakistan. In Asian Pac J Cancer Prev, 2014
BACKGROUND: Gradual loss of cytokeratin 13 (CK13) may be linked with the severity of dysplastic changes and transformation to malignancy.
Comparative study of cytokeratin and langerin expression in keratinized cystic lesions of the oral and maxillofacial regions.
Sakashita et al., Oral, Kazakhstan. In J Oral Sci, 2014
Positive reactivity for CK13 and 17 was evident in OOCs, but not in DMCs/EDMCs.
Current approaches to the diagnosis and treatment of white sponge nevus.
Review
Liu et al., Shanghai, China. In Expert Rev Mol Med, 2014
The genes associated with WSN include mutant cytokeratin keratin 4 (KRT4) and keratin 13 (KRT13).
Notch as a Possible Cell Differentiation Factor in Pleomorphic Adenomas.
Kawakami et al., Shiojiri, Japan. In Int J Med Sci, 2014
CK13 expression was observed in cells undergoing squamous metaplasia and Notch expression was seen in the nucleus of basal and squamous cells.
Cytokeratin 13, Cytokeratin 17, Ki-67 and p53 Expression in Upper Layers of Epithelial Dysplasia Surrounding Tongue Squamous Cell Carcinoma.
Katakura et al., Tokyo, Japan. In Bull Tokyo Dent Coll, 2014
The purpose of this study was to investigate expression of cytokeratin 13 (CK13), CK17, Ki-67 and p53 as potential markers of tongue SCC.
Relevance of cancer initiating/stem cells in carcinogenesis and therapy resistance in oral cancer.
Review
Bhutia et al., India. In Oral Oncol, 2013
Oral CSCs populations show upregulation of the stem cell related genes Oct-4, Nanog, Nestin, CK19, BMI-1, CD117 (c-kit), CD44 and CD133 with sunken expression of involucrin and CK13.
Loss of keratin 13 in oral carcinoma in situ: a comparative study of protein and gene expression levels using paraffin sections.
GeneRIF
Saku et al., Niigata, Japan. In Mod Pathol, 2012
Loss of K13 in oral carcinoma in situ is partly due to its gene repression, but may also be due to some unknown post-translational events.
Down-regulation of keratin 4 and keratin 13 expression in oral squamous cell carcinoma and epithelial dysplasia: a clue for histopathogenesis.
GeneRIF
Yamaguchi et al., Tokyo, Japan. In Histopathology, 2011
The aberrant expression of K4 and K13 and concomitant up-regulation of the other keratins may be one of the causative factors for morphological alterations in the affected epithelium.
Keratin 13 is a more specific marker of conjunctival epithelium than keratin 19.
GeneRIF
Deng et al., Los Angeles, United States. In Mol Vis, 2010
Keratin 13 is a more specific marker of conjunctival epithelium than keratin 19.
Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 cooperates with Myc to promote lymphoma in mice.
GeneRIF
Chaudhary et al., Pittsburgh, United States. In Cancer Biol Ther, 2010
K13 cooperates with Myc to promote lymphoma through elevated NF-kappaB.
Expression of cytokeratins 10, 13, 14 and 19 in oral lichen planus.
GeneRIF
Ramos-e-Silva et al., Rio de Janeiro, Brazil. In J Oral Sci, 2009
Expression was altered in oral lichen planus lesions
Calcifications in a clear cell mucoepidermoid carcinoma: a case report with histological and immunohistochemical findings.
Review
Carvalho et al., São José dos Campos, Brazil. In Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2007
Immunohistochemistry was performed, and the epidermoid component was positive for cytokeratin (CK)7, CK13, CK14, and CK19.
Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkers.
Review
Skaland et al., Bergen, Norway. In J Clin Pathol, 2006
Functional biomarkers p16, Ki-67, p53, retinoblastoma protein cytokeratin (CK)14 and CK13, help in the assessment of an individual CIN's lesion's potential for progression and regression.
Canalicular adenoma arising in the upper lip: review of the pathological findings.
Review
Inoue et al., Oral, Kazakhstan. In Bull Tokyo Dent Coll, 2004
The tumor cells were immunoreactive to AE1/AE3, CK19 and S-100, were partially positive for CK7, CK8, GFAP and PCNA, but were negative for SMA, CK13, CK14 and vimentin.
Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus.
Impact
Compton et al., Bethesda, United States. In Nat Genet, 1995
We identified a missense mutation in one allele of keratin 13 that leads to proline substitution for a conserved leucine.
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