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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Complement component 1, s subcomponent

CIs, C1s, cis-1, SOCS1, SOCS
This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: HAD, AGE, KSR, HRs, CAN
Papers using CIs antibodies
Papers on CIs
Overexpression of Bcl-2, SOCS 1, 3 and Cdh 1, 2 are associated with the early neoplasic changes in modified 4-nitroquinoline 1-oxide-induced murine oral cancer model.
New
Spolidorio et al., Paulista, Brazil. In J Oral Pathol Med, Feb 2016
BACKGROUND: The objective was to assess histopathological changes and the expression of proliferating cell nuclear antigen (PCNA), Bcl-2, suppressor of cytokine signaling (SOCS) 1 and 3, Vimentin, TWIST1, and Cdh 1 and 2 in early stages of experimental oral carcinogenesis process using a shorter period of exposure to 4-nitroquinoline oxide (4-NQO) model.
Lack of association between the Angiogenin (ANG) rs11701 polymorphism and amyotrophic lateral sclerosis risk: a meta-analysis.
Review
New
Ding et al., Yichun, China. In Neurol Sci, Feb 2016
Analysis of pooled ORs and 95 % CIs suggested lack of association between the ANG rs11701 polymorphism and risk for ALS, Familial ALS or Sporadic ALS (all p value for z test >0.05).
Suppressor of cytokine signaling 1 expression in peripheral blood mononuclear cells of hepatitis C genotype 1 patients.
New
Yen et al., Kao-hsiung, Taiwan. In J Formos Med Assoc, Feb 2016
RESULTS: Suppressor of cytokine signaling 1 (SOCS1) expression was upregulated in SVR patients compared with non-SVR patients (relative quantification = 2.14) based on a multiplex reverse transcription-polymerase chain reaction analysis.
The Efficacy of Erlotinib Versus Conventional Chemotherapy for Advanced Nonsmall-Cell Lung Cancer: A PRISMA-Compliant Systematic Review With Meta-Regression and Meta-Analysis.
Review
New
Zhou et al., Zunyi, China. In Medicine (baltimore), Jan 2016
HR with 95% confidence intervals (CIs) for progression-free survival (PFS) and overall survival (OS), relative risk (RR) with 95% CIs for objective response rate (ORR) and 1-year survival rate (OSR) were all extracted.
Cytotoxicity-boosting of kiteplatin by Pt(IV) prodrugs with axial benzoate ligands.
New
Natile et al., Bari, Italy. In J Inorg Biochem, Jan 2016
UNASSIGNED: Kiteplatin, the neglected drug analogous of cisplatin but containing cis-1,4-DACH in place of the two ammines, has been recently reevaluated for its activity against cisplatin- and oxaliplatin-resistant tumors, in particular colo-rectal cancer.
Association of IL-23R Polymorphisms (rs6682925, rs10889677, rs1884444) With Cancer Risk: A PRISMA-Compliant Meta-Analysis.
Review
New
Dai et al., Xi'an, China. In Medicine (baltimore), Dec 2015
Case-only studies and review papers were excluded.Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the relationship of IL-23R polymorphisms (rs6682925, rs10889677, rs1884444) with cancer risk.
Vitamin D Receptor Gene FokI Polymorphism Contributes to Increasing the Risk of Tuberculosis: An Update Meta-Analysis.
Review
New
Chen et al., Lithuania. In Medicine (baltimore), Dec 2015
The odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were calculated according to the frequencies of genotypes.In total, 32 studies with 4894 cases and 5319 controls were included in this meta-analysis.
Myeloproliferative neoplasms: Current molecular biology and genetics.
Review
New
Saeidi, Kermān, Iran. In Crit Rev Oncol Hematol, Dec 2015
Some other genes' location such as TET oncogene family member 2 (TET2), additional sex combs-like 1 (ASXL1), casitas B-lineage lymphoma proto-oncogene (CBL), isocitrate dehydrogenase 1/2 (IDH1/IDH2), IKAROS family zinc finger 1 (IKZF1), DNA methyltransferase 3A (DNMT3A), suppressor of cytokine signaling (SOCS), enhancer of zeste homolog 2 (EZH2), tumor protein p53 (TP53), runt-related transcription factor 1 (RUNX1) and high mobility group AT-hook 2 (HMGA2) have also identified to be involved in MPNs phenotypes.
Genome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy.
New
Impact
Cerhan et al., Bordeaux, France. In J Clin Oncol, Dec 2015
We calculated the hazard ratios (HRs) and 95% CIs for event-free survival (EFS) and overall survival (OS) using a log-additive genetic model with adjustment for age, sex, and age-adjusted International Prognostic Index.
Psychosocial and Neurocognitive Outcomes in Adult Survivors of Adolescent and Early Young Adult Cancer: A Report From the Childhood Cancer Survivor Study.
New
Impact
Krull et al., New Orleans, United States. In J Clin Oncol, Sep 2015
Logistic regression models were used to compute odds ratios (ORs) and corresponding 95% CIs.
Bias Correction Methods Explain Much of the Variation Seen in Breast Cancer Risks of BRCA1/2 Mutation Carriers.
Review
New
Impact
de Bock et al., Groningen, Netherlands. In J Clin Oncol, Sep 2015
CLTRs and 95% CIs were estimated and compared with the reference CLTRs.
A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner.
New
Impact
Rudensky et al., New York City, United States. In Immunity, Aug 2015
To explore in vivo the function of a single miRNA-mRNA interaction, we mutated the 3' UTR of a major miR-155 target (SOCS1) to specifically disrupt its regulation by miR-155.
miR-155-SOCS1 as a Functional Axis: Satisfying the Burden of Proof.
New
Impact
O'Connell et al., Salt Lake City, United States. In Immunity, Aug 2015
In this issue of Immunity, Lu et al. (2015) disrupt the miR-155 binding site in the SOCS1 3' UTR in the mouse germline and show that this axis is important for T and NK cell function.
Genetic variants at 6p21, 10q23, 16q21 and 22q12 are associated with esophageal cancer risk in a Chinese Han population.
Jin et al., Taiwan. In Int J Clin Exp Med, 2014
Odds ratios and 95% confidence intervals (CIs) were calculated by unconditional logistic regression with adjustments for age and gender.
Interleukin-10 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis.
Liu et al., Foshan, China. In Genet Mol Res, 2014
Odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated for each genetic model and allelic comparison.
Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s.
GeneRIF
Wijeyewickrema et al., Australia. In J Immunol, 2012
Four positively charged amino acids on the serine protease domain appear to form a catalytic exosite that is required for efficient cleavage of C4 in the classical pathway of complement.
SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control.
GeneRIF
Study Alliance Leukemia (SAL) et al., Frankfurt am Main, Germany. In Blood, 2012
Socs1 accelerates the onset of Flt3-internal tandem duplication - induced myeloproliferative disease by promoting the escape from external cytokine control.
Suppressor of cytokine signaling 1 DNA administration inhibits inflammatory and pathogenic responses in autoimmune myocarditis.
GeneRIF
Yasutomi et al., Tsukuba, Japan. In J Immunol, 2012
Our findings suggest that SOCS1 DNA administration has considerable therapeutic potential in individuals with autoimmune myocarditis and dilated cardiomyopathy
Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses.
GeneRIF
Dalpke et al., Heidelberg, Germany. In J Immunol, 2012
SOCS1 is expressed via a new, NF-kappaB-independent pathway in Dectin-1-triggered murine bone marrow macrophages and influences Toll-like receptor cross-talk and T cell priming.
A requirement for SOCS-1 and SOCS-3 phosphorylation in Bcr-Abl-induced tumorigenesis.
GeneRIF
Chen et al., Beijing, China. In Neoplasia, 2012
Bcr-Abl may critically requires tyrosine phosphorylation of SOCS-1 and SOCS-3 to mediate tumorigenesis when these SOCS proteins are present in cells.
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