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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Suppressor of cytokine signaling 5

cis-6, SOCS5
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CIs, ACID, SOCS3, CAN, HAD
Papers on cis-6
Astragalin Attenuates Allergic Inflammation in a Murine Asthma Model.
New
Ma et al., Xianyang, China. In Inflammation, Oct 2015
Western blot analysis demonstrated that AG treatments markedly inhibited OVA-induced SOCS-3 expression and enhancement of SOCS-5 expression in an asthma model.
Mild Approach to 2-Acylfurans via Intercepted Meyer-Schuster Rearrangement of 6-Hydroxyhex-2-en-4-ynals.
New
Baire et al., Chennai, India. In J Org Chem, Sep 2015
We have developed a mild, intramolecular intercepted Meyer-Schuster (M-S) rearrangement for the synthesis of 2-acylfurans from corresponding cis-6-hydroxyhex-2-en-4-ynals.
Structure and Functional Characterization of the Conserved JAK Interaction Region in the Intrinsically Disordered N-Terminus of SOCS5.
New
Norton et al., Australia. In Biochemistry, Sep 2015
SOCS5 can negatively regulate both JAK/STAT and EGF-receptor pathways and has therefore been implicated in regulating both the immune response and tumorigenesis.
A CB2-Selective Cannabinoid Suppresses T-Cell Activities and Increases Tregs and IL-10.
New
Eisenstein et al., Philadelphia, United States. In J Neuroimmune Pharmacol, Jun 2015
Additionally, a gene expression profile of purified T-cells from MLR cultures generated using a PCR T-cell activation array showed that O-1966 decreased mRNA expression of CD40 ligand and CyclinD3, and increased mRNA expression of Src-like-adaptor 2 (SLA2), Suppressor of Cytokine Signaling 5 (SOCS5), and IL-10.
Suppressor of cytokine signaling (SOCS) genes are silenced by DNA hypermethylation and histone deacetylation and regulate response to radiotherapy in cervical cancer cells.
Jeong et al., Seoul, South Korea. In Plos One, 2014
All cervical cancer cell lines tested showed lower expression of SOCS1, SOCS3, and SOCS5 than normal tissue or cell lines.
Effect of early vitamin D supplementation on asthma and the possible mechanisms.
Jiang et al., Guangzhou, China. In Genet Mol Res, 2014
Its mechanism may correlate with the effect of 1,25(OH)2D3 on interleukin (IL)-4, IL-12, IL-13, interferon-γ, and ovalbumin-specific immunoglobulin E secretion and the expression of p-JAK1/p-STAT6/SOCS5.
Targeted Analysis Reveals an Important Role of JAK-STAT-SOCS Genes for Milk Production Traits in Australian Dairy Cattle.
Williamson et al., Sydney, Australia. In Front Genet, 2014
Gene expression studies using qRT-PCR revealed differential expression of SOCS2, SOCS4, and SOCS5 genes across the lactation cycle in dairy cows.
Eleven Microbial Metabolites of 6-Hydroxyflavanone.
Khan et al., United States. In Chem Pharm Bull (tokyo), 2014
Mucor ramannianus (ATCC 9628) transformed 1 to 2,4-cis-6-hydroxyflavan-4-ol (8), 2,4-trans-6-hydroxyflavan-4-ol (9), 2,4-trans-6,4'-dihydroxyflavan-4-ol 5-sulfate (10), 1,3-cis-1-methoxy-1-(2,5-dihydroxyphenyl)-3-phenylpropane (11) and 2,4-trans-flavan-4-ol 6-sulfate (12).
Effect of Three Training Systems on Grapes in a Wet Region of China: Yield, Incidence of Disease and Anthocyanin Compositions of Vitis vinifera cv. Cabernet Sauvignon.
Zhang et al., Taiwan. In Molecules, 2014
A wet vintage of 2013 had more accumulation of 3'5'-substituted and acylated anthocyanins, including malvidin-3-O-(6-O-acetyl)-glucoside, malvidin-3-O-glucoside, and petunidin-3-O-(cis-6-O-coumaryl)-glucoside, etc.
The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.
GeneRIF
Norton et al., Australia. In Proteins, 2012
Identified is a conserved region of about 70 residues in the N-terminal domains of Socs4 and 5 that is predicted to be more ordered than the surrounding sequence.
SOCS5 and SOCS6 have similar expression patterns in normal and cancer tissues.
GeneRIF
Nam et al., South Korea. In Tumour Biol, 2012
The results may contribute to understanding SOCS5 and SOCS6 expression regulation in various cancer tissues, and show that these two factors may be used for diagnosing cancer.
Host- and microbe determinants that may influence the success of S. aureus colonization.
Review
Hanssen et al., Tromsø, Norway. In Front Cell Infect Microbiol, 2011
The level of β-defensin 3, free sphingosine, and cis-6-hexadecenoic acid are found to be associated with nasal carriage of S. aureus.
Regulation of epidermal growth factor receptor signalling by inducible feedback inhibitors.
Review
Alemà et al., Roma, Italy. In J Cell Sci, 2011
In mammalian cells, four EGFR inducible feedback inhibitors (IFIs), namely LRIG1, RALT (also known as MIG6 and ERRFI1), SOCS4 and SOCS5, have been discovered recently.
Fms-like tyrosine kinase 3 ligand decreases T helper type 17 cells and suppressors of cytokine signaling proteins in the lung of house dust mite-sensitized and -challenged mice.
GeneRIF
Agrawal et al., Omaha, United States. In Am J Respir Cell Mol Biol, 2010
The effect of Flt3-L on Th17 cells and expression of suppressors of cytokine signaling (SOCS) proteins in the lungs of house dust mite (HDM)-sensitized and -challenged mice, was evaluated.
Knocking off the suppressors of cytokine signaling (SOCS): their roles in mammalian pregnancy.
Review
Markert et al., Jena, Germany. In J Reprod Immunol, 2009
SOCS5 inhibits IL-4 signaling, yet the SOCS5 transgenic mouse has no conspicuous reproductive phenotype.
[Expression of suppressor of cytokine signaling in peripheral blood monocular cells of patients with Vogt-Koyanagi-Harada disease].
GeneRIF
Zhou et al., Beijing, China. In Zhonghua Yan Ke Za Zhi, 2009
Up regulation of SOCS1 and SOCS5 expression and down-regulation of SOCS3 and CIS may correlate with the development of a Th1 mediated immune response in Vogt-Koyanagi-Harada disease.
Feedback inhibitors of the epidermal growth factor receptor signaling pathways.
Review
Gotoh, Tokyo, Japan. In Int J Biochem Cell Biol, 2009
The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1).
[Expression of suppressor of cytokine signaling in retina of experimental autoimmune uveoretinitis].
GeneRIF
Zhao et al., Beijing, China. In Zhonghua Yan Ke Za Zhi, 2008
Up-regulation of SOCS5 may have protective functions in experimental autoimmune uveoretinitis.
Role of endogenous inhibitors of cytokine signaling in allergic asthma.
Review
Yoshimura et al., Fukuoka, Japan. In Curr Med Chem, 2006
SOCS3 and SOCS5 are predominantly expressed in Th2 and Th1 cells, respectively, and they reciprocally inhibit the Th1 and Th2 differentiation processes.
Autoxidation of insect lipids: inhibition on the cuticle of the American cockroach.
Impact
Gilby et al., In Science, 1970
The major hydrocarbon, cis, cis-6,9-heptacosadiene, of Periplaneta americana cuticles and oothecae solidifies in air by autoxidation.
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