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Suppressor of cytokine signaling 6

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CIs, ACID, HAD, Rdl, CAN
Papers on cis-4
Aerobic and anaerobic microbial degradation of crude (4-methylcyclohexyl)methanol in river sediments.
Zhang et al., Beijing, China. In Sci Total Environ, Feb 2016
A nearly complete aerobic degradation of 4-MCHM occurred within 14days, whereas the anaerobic degradation was reluctant with residual percentages of 62.6% of cis-4-MCHM and 85.0% of trans-4-MCHM after 16-day incubation.
Inhibition of soluble epoxide hydrolase does not improve the course of congestive heart failure and the development of renal dysfunction in rats with volume overload induced by aorto-caval fistula.
Sadowski et al., Praha, Czech Republic. In Physiol Res, Jan 2016
Chronic treatment with cis-4-[4-(3-adamantan-1-yl-ureido) cyclohexyloxy]benzoic acid (c-AUCB, 3 mg/l in drinking water), an inhibitor of soluble epoxide hydrolase (sEH) which normally degrades EETs, increased intrarenal and myocardial EETs to levels observed in sham-operated HanSD rats, but did not improve the survival or renal function impairment.
Substituent effect study on experimental ¹³C NMR chemical shifts of (3-(substituted phenyl)-cis-4,5-dihydroisoxazole-4,5-diyl)bis(methylene)diacetate derivatives.
Kara, Kocaeli, Turkey. In Spectrochim Acta A Mol Biomol Spectrosc, Jan 2016
Eleven novel (3-(substituted phenyl)-cis-4,5-dihydroisoxazole-4,5-diyl)bis(methylene) diacetate derivatives were synthesized in the present study.
Structural Properties and Stereochemically Distinct Folding Preferences of 4,5-cis and trans-Methano-L-Proline Oligomers: The Shortest Crystalline PPII-Type Helical Proline-Derived Tetramer.
Hanessian et al., Montréal, Canada. In Angew Chem Int Ed Engl, Dec 2015
Experimental evidence of PPII-type helical arrangement (both in solution and in the solid state) of cis-4,5-methano-L-proline oligomers is supported by theoretical calculations reflecting the extent of n→π* stabilization of the trans-amide conformation.
Sustainable source of omega-3 eicosapentaenoic acid from metabolically engineered Yarrowia lipolytica: from fundamental research to commercial production.
Zhu et al., Wilmington, United States. In Appl Microbiol Biotechnol, Feb 2015
The omega-3 fatty acids, cis-5, 8, 11, 14, and 17-eicosapentaenoic acid (C20:5; EPA) and cis-4, 7, 10, 13, 16, and 19-docosahexaenoic acid (C22:6; DHA), have wide-ranging benefits in improving heart health, immune function, mental health, and infant cognitive development.
Amino acids in sandal (Santalum album L) with special reference to cis-4-hydroxy-l-proline and sym. homospermidine.
Binitha et al., Trichūr, India. In Springerplus, 2014
This includes cis-4-hydroxy-l-proline in free form in leaves, flowers and seeds while trans-4-hydroxy-l-proline in bound form.
Isomers of 4-[18F]fluoro-proline: radiosynthesis, biological evaluation and results in humans using PET.
Langen et al., Jülich, Germany. In Curr Radiopharm, 2013
A number of studies have explored cis-4-[(18)F]fluoro-L-proline uptake in various pathologies associated with increased collagen formation and in neoplastic lesions, but so far the results have not been very promising.
Discovery of new enzymes and metabolic pathways by using structure and genome context.
Jacobson et al., San Francisco, United States. In Nature, 2013
Here we report that structure-guided approaches for predicting the substrate specificities of several enzymes encoded by a bacterial gene cluster allowed the correct prediction of the in vitro activity of a structurally characterized enzyme of unknown function (PDB 2PMQ), 2-epimerization of trans-4-hydroxy-L-proline betaine (tHyp-B) and cis-4-hydroxy-D-proline betaine (cHyp-B), and also the correct identification of the catabolic pathway in which Hyp-B 2-epimerase participates.
Properties, metabolisms, and applications of (L)-proline analogues.
Takagi et al., Việt Trì, Vietnam. In Appl Microbiol Biotechnol, 2013
Many hydroxyprolines (HOPs), such as 4-L-THOP and cis-4-hydroxy-L-proline (4-L-CHOP), are useful chiral building blocks for the organic synthesis of pharmaceuticals.
Leung, Bethesda, United States. In Unknown Journal, 2012
(3-Ethyl-2-methyl-6-quinolinyl)(cis-4-methoxycyclohexyl)methanone (JNJ-16567083) was shown to be a selective mGluR1 antagonist with nanomolar affinity (Ki = 0.87 nM) with little inhibition of mGluR5 (5).
SOCS5 and SOCS6 have similar expression patterns in normal and cancer tissues.
Nam et al., South Korea. In Tumour Biol, 2012
The results may contribute to understanding SOCS5 and SOCS6 expression regulation in various cancer tissues, and show that these two factors may be used for diagnosing cancer.
Array-comparative genomic hybridization reveals loss of SOCS6 is associated with poor prognosis in primary lung squamous cell carcinoma.
Fong et al., Brisbane, Australia. In Plos One, 2011
Reduced copy number and mRNA expression of SOCS6 are associated with disease recurrence in primary lung squamous cell carcinoma and may be useful prognostic biomarkers.
Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase.
Flores-Morales et al., Stockholm, Sweden. In J Biol Chem, 2011
SOCS6 has ubiquitin ligase activity toward c-KIT
SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation.
Yun et al., Seoul, South Korea. In J Biol Chem, 2010
These results establish that SOCS-6 acts as a negative regulator of T cell activation by promoting ubiquitin-dependent proteolysis of p56(lck).
Genomic organization and functional characterization of the promoter for the human suppressor of cytokine signaling 6 gene.
Chen et al., Taipei, Taiwan. In Gene, 2010
Study demonstrated that hypermethylation of the SOCS6 promoter is one of the mechanisms for the epigenetic regulation of SOCS6 expression.
Seasonal effects in the nutritional quality of the body structural tissue of cephalopods.
Türeli et al., Adana, Turkey. In Food Chem, 2008
and cis-4,7,10,13,16,19-docosahexaenoic acid (DHA, C22:6 n-3, 20.99-39.00%).
Pharmacology of GABA receptor Cl- channels in rat retinal bipolar cells.
Bormann et al., Frankfurt am Main, Germany. In Nature, 1993
The bicuculline- and baclofen-insensitive GABA receptors were activated selectively by the GABA analogue cis-4-aminocrotonic acid (CACA).
Novel GABA responses from rod-driven retinal horizontal cells.
Dowling et al., Cambridge, United States. In Nature, 1993
For some years, evidence has accumulated that there are GABA receptors, especially prominent along visual pathways, which are neither antagonized by bicuculline nor activated by baclofen, but are activated by certain conformationally restricted analogues of GABA, including cis-4-aminocrotonic acid (CACA).
Nonenzymatic hydroxylations of proline and lysine by reduced oxygen derivatives.
Holmes et al., In Nature, 1981
We found that these small peptides contained the trans-3 and cis-4 isomers of hydroxyproline as well as trans-4 ones and that their production was not completely inhibited by alpha, alpha-dipyridyl, and iron chelator and effective inhibitor of enzyme-mediated hydroxylations.
Cytokinins in the soluble RNA of plant tissues.
McLennan et al., In Science, 1967
A hydroxylated derivative of this cytokinin 6-(cis-4-hydroxy-3-methylbut-2-enylamino)-9-,beta-D-ribofuranosylpurine has also been identified as a constituent of plant soluble RNA.
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