Architecture of tight junctions and principles of molecular composition.
Bethesda, United States. In Semin Cell Dev Biol, 2014
In general the architecture can be conceptualized into compartments with the transmembrane barrier proteins (claudins, occludin, JAM-A, etc.), linked to peripheral scaffolding proteins (such as ZO-1, afadin, MAGI1, etc.) which are in turned linked to actin and microtubules through numerous linkers (cingulin, myosins, protein 4.1, etc.).
The blood-aqueous barrier in health and disease.
Oviedo, Spain. In J Glaucoma, 2014
Tight junctions (ie, junctional adhesion molecules, claudins, occludins, zonula occludens, cingulin) are part of the apical junctional complex that also includes the adherens junctions (ie, cadherin-catenin and nectin-afadin complexes) and the gap junctions (ie, connexins).
The blood-brain barrier/neurovascular unit in health and disease.
Tucson, United States. In Pharmacol Rev, 2005
The TJ is an intricate complex of transmembrane (junctional adhesion molecule-1, occludin, and claudins) and cytoplasmic (zonula occludens-1 and -2, cingulin, AF-6, and 7H6) proteins linked to the actin cytoskeleton.