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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ciliary neurotrophic factor

Ciliary Neurotrophic Factor, CNTF
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: CAN, Brain-derived neurotrophic factor, LIF, NMDA receptor, Interleukin-6
Papers on Ciliary Neurotrophic Factor
YAP Is a Critical Inducer of SOCS3, Preventing Reactive Astrogliosis.
New
Xiong et al., Wenzhou, China. In Cereb Cortex, Jan 2016
At the molecular level, YAP in astrocytes was activated by IFNβ or ciliary neurotrophic factor (CNTF), which was necessary for IFNβ or CNTF induction of the suppressor of cytokine signaling 3 (SOCS3), a negative regulator of the Janus kinase-signal transducer and activator of transcription (JAK-STAT) inflammatory pathway.
Pro-neurogenic effect of β-asarone on RSC96 Schwann cells in vitro.
New
Zhao et al., Nanning, China. In In Vitro Cell Dev Biol Anim, Jan 2016
β-Asarone could promote expression of GDNF, BDNF, and CNTF genes (p < 0.05).
Epac2 contributes to PACAP-induced astrocytic differentiation through calcium ion influx in neural precursor cells.
New
Lee et al., Taegu, South Korea. In Bmb Rep, Jan 2016
During neuro-embryogenesis, astrocytogenesis involves astrocytic differentiation of neural precursor cells (NPCs) induced by signals from ciliary neurotrophic factor (CNTF) or pituitary adenylate cyclase-activating peptide (PACAP).
Neurotrophin signaling in a genitofemoral nerve target organ during testicular descent in mice.
New
Hutson et al., Melbourne, Australia. In J Pediatr Surg, Jan 2016
Sagittal sections of IFP, mammary area and bulbocavernosus (BC) muscle were processed for standard histology and fluorescent immunohistochemistry for ciliary neurotrophic factor (CNTF), ciliary neurotrophic factor receptor (CNTFR) and cell nuclei (DAPI).
The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury.
New
Karaoz et al., İstanbul, Turkey. In Turk Neurosurg, Dec 2015
The regeneration process was evaluated based on immunostaining against β3-tubulin, BDNF, CNTF, and CNPase.
Ciliary neurotrophic factor (CNTF): New facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies.
Review
New
Gauchat et al., Montréal, Canada. In Cytokine Growth Factor Rev, Oct 2015
Ciliary neurotrophic factor (CNTF) is the most extensively studied member of the cytokine family that signal through intracellular chains of the gp130/LIFRβ receptor.
Leukemia inhibitory factor (LIF).
Review
New
Babon et al., Melbourne, Australia. In Cytokine Growth Factor Rev, Oct 2015
It utilises a receptor that consists of the LIF receptor β and gp130 and this receptor complex is also used by ciliary neurotrophic growth factor (CNTF), oncostatin M, cardiotrophin1 (CT1) and cardiotrophin-like cytokine (CLC).
Achromatopsia: a review.
Review
New
Ceisler et al., New York City, United States. In Curr Opin Ophthalmol, Jul 2015
Two clinical trials are under way: one to better characterize humans with achromatopsia and another to study a ciliary neurotrophic factor (CNTF) implant as a treatment for patients with the CNGB3 mutation.
The role of SATB2 in skeletogenesis and human disease.
Review
Zhang et al., Shanghai, China. In Cytokine Growth Factor Rev, 2014
At the molecular level, Satb2 gene expression appears to be tissue and stage-specific, and is regulated by several cytokines and growth factors, such as BMP2/4/7, insulin, CNTF, and LIF via ligand receptor signaling pathways.
Trophic factors as modulators of motor neuron physiology and survival: implications for ALS therapy.
Review
Tapia et al., Mexico. In Front Cell Neurosci, 2013
Among the trophic factors that have been demonstrated to participate in motor neuron physiology are vascular endothelial growth factor (VEGF), glial-derived neurotrophic factor (GDNF), ciliary neurotrophic factor (CNTF) and insulin-like growth factor 1 (IGF-1).
Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice.
GeneRIF
Hagg et al., Louisville, United States. In J Neurosci, 2012
Contact-mediated integrin signaling between neurons and astrocytes normally represses CNTF expression; neuronal dysfunction causes a rapid protective response by the brain in stroke.
Increased expression of IL-6 family members in tendon pathology.
GeneRIF
Riley et al., Norwich, United Kingdom. In Rheumatology (oxford), 2012
Ciliary neurotrophic factor levels were increased in painful PTT only.
Ciliary neurotrophic factor stimulates tyrosine hydroxylase activity.
GeneRIF
Habecker et al., Portland, United States. In J Neurochem, 2012
CNTF decreased TH enzyme levels, thereby increasing the specific activity of the enzyme
Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behavior.
GeneRIF
Linker et al., Bochum, Germany. In Behav Brain Res, 2012
results demonstrate that endogenous CNTF in the CNS is a pivotal regulator of depressive-like and anxiety-like behavior via effects on GABAergic neurons and associated serotonergic neurotransmission.
The anorexigenic cytokine ciliary neurotrophic factor stimulates POMC gene expression via receptors localized in the nucleus of arcuate neurons.
GeneRIF
Vacher et al., Orsay, France. In Am J Physiol Endocrinol Metab, 2012
The data strongly suggested that intracellular ciliary neurotrophic factor may directly modulate proopiomelanocortin gene expression via the activation of ciliary neurotrophic factor receptors in the cell nucleus.
Spatially controlled simultaneous patterning of multiple growth factors in three-dimensional hydrogels.
Impact
Shoichet et al., Toronto, Canada. In Nat Mater, 2011
Stem-cell differentiation factors sonic hedgehog (SHH) and ciliary neurotrophic factor (CNTF) were simultaneously immobilized using orthogonal physical binding pairs, barnase-barstar and streptavidin-biotin, respectively.
Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells.
Impact
Fine et al., Bethesda, United States. In Cancer Cell, 2008
We now demonstrate that both bone morphogenetic protein (BMP)-mediated and ciliary neurotrophic factor (CNTF)-mediated Jak/STAT-dependent astroglial differentiation is impaired due to EZH2-dependent epigenetic silencing of BMP receptor 1B (BMPR1B) in a subset of glioblastoma TICs.
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.
Impact
Steinberg et al., Melbourne, Australia. In Nat Med, 2006
Ciliary neurotrophic factor (CNTF) induces weight loss and improves glucose tolerance in humans and rodents.
Neurogenesis in the hypothalamus of adult mice: potential role in energy balance.
Impact
Flier et al., Boston, United States. In Science, 2005
Ciliary neurotrophic factor (CNTF) induces weight loss in obese rodents and humans, and for reasons that are not understood, its effects persist after the cessation of treatment.
N-CoR controls differentiation of neural stem cells into astrocytes.
Impact
Rosenfeld et al., San Diego, United States. In Nature, 2002
Stimulation of wild-type neural stem cells with ciliary neurotrophic factor (CNTF), a differentiation-inducing cytokine, results in phosphatidylinositol-3-OH kinase/Akt1 kinase-dependent phosphorylation of N-CoR, and causes a temporally correlated redistribution of N-CoR to the cytoplasm.
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