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Cell death-inducing DFFA-like effector b

CIDEB, cell death-inducing DFFA-like effector B
Top mentioned proteins: ICAD, CIDEA, FSP27, HAD, ACID
Papers on CIDEB
Differential Roles of CIDE Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes.
New
Zhou et al., China. In J Biol Chem, Feb 2016
CIDE proteins including Cidea, Cideb and Cidec (also called Fsp27) play important roles in lipid metabolism.
The p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human medulloblastoma cells.
New
Albanese et al., Washington, D.C., United States. In Aging (albany Ny), Oct 2015
The inhibition of p53 in the presence of VMY revealed increased late stage apoptosis, increased DNA fragmentation and increased expression of genes involved in apoptosis, including CAPN12 and TRPM8, p63, p73, BIK, EndoG, CIDEB, P27Kip1 and P21cip1.
Altered expression of apoptotic genes in response to OCT4B1 suppression in human tumor cell lines.
Mowla et al., Tehrān, Iran. In Tumour Biol, 2014
Among these, some up-regulated (CIDEA, CIDEB, TNFRSF1A, TNFRSF21, TNFRSF11B, TNFRSF10B, and CASP7) and down-regulated (BCL2, BCL2L11, TP73, TP53, BAD, TRAF3, TRAF2, BRAF, BNIP3L, BFAR, and BAX) genes had on average more than tenfold gene expression alteration in all three examined cell lines.
Investigating the antiviral role of cell death-inducing DFF45-like effector B in HCV replication.
Pezacki et al., Ottawa, Canada. In Febs J, 2014
Cell-death-inducing DFF45-like effector B (CIDEB) is an apoptotic host factor, which was recently found to also regulate hepatic lipid homeostasis.
Cell death-inducing DFFA-like effector b is required for hepatitis C virus entry into hepatocytes.
Tang et al., Tallahassee, United States. In J Virol, 2014
We suppressed the expression of a liver-specific protein, cell death-inducing DFFA-like effector b (CIDEB), and performed hepatocyte function and HCV infection assays.
Cideb facilitates the lipidation of chylomicrons in the small intestine.
Ye et al., Xi'an, China. In J Lipid Res, 2014
Cell death-inducing DFF45-like effector b (Cideb), an endoplasmic reticulum (ER)- and lipid droplet (LD)-associated protein, has been shown to play a critical role in maintaining hepatic lipid homeostasis by promoting the lipidation and maturation of VLDL particles.
Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation.
Lupton et al., College Station, United States. In Exp Biol Med (maywood), 2014
To determine if DHA and/or butyrate elevate apoptosis through epigenetic mechanisms thereby restoring the transcription of apoptosis-related genes, we examined global methylation; gene-specific promoter methylation of 24 apoptosis-related genes; transcription levels of Cideb, Dapk1, and Tnfrsf25; and global histone acetylation in the HCT-116 colon cancer cell line.
Protective effect of acetyl-l-carnitine against cisplatin ototoxicity: role of apoptosis-related genes and pro-inflammatory cytokines.
Guneri et al., İzmir, Turkey. In Cell Prolif, 2014
Genes displaying increase in expression of apoptosis, related to cisplatin treatment, were Casp8, Bcl10, Bcl2, Bcl2l1, Bcl2l2, Bid, Naip1, Bnip3l, Card6, Pak7, Cd40, Trp 53inp1, Cideb and Cd70.
Human serum activates CIDEB-mediated lipid droplet enlargement in hepatoma cells.
Pezacki et al., Ottawa, Canada. In Biochem Biophys Res Commun, 2013
Human hepatocytes constitutively express the lipid droplet (LD) associated protein cell death-inducing DFFA-like effector B (CIDEB).
Expression of CIDE proteins in clear cell renal cell carcinoma and their prognostic significance.
Ye et al., Xi'an, China. In Mol Cell Biochem, 2013
Cideb was down-regulated.
Enantioselective induction of cytotoxicity by o,p'-DDD in PC12 cells: implications of chirality in risk assessment of POPs metabolites.
Liu et al., Hangzhou, China. In Environ Sci Technol, 2013
We have documented for the first time that R-(+)-o,p'-DDD increases apoptosis by selectively disturbing the oxidative system (enzymes and molecules) and regulating the transcription of Aven, Bid, Cideb and Tp53.
CIDE proteins and lipid metabolism.
Review
Li et al., Beijing, China. In Arterioscler Thromb Vasc Biol, 2012
Cell death-inducing DNA fragmentation factor 45-like effector family proteins, including Cidea, Cideb, and Fsp27 (Cidec), are emerging as important regulators of various lipid metabolic pathways and play pivotal roles in the development of metabolic disorders.
Which CIDE are you on? Apoptosis and energy metabolism.
Review
Inoko et al., Japan. In Mol Biosyst, 2011
Around 1998, cell death-inducing DNA fragmentation factor-alpha (DFFA)-like effector (CIDE) proteins including CIDEA, CIDEB and CIDEC/fat specific protein 27 (Fsp27) were first identified by their sequence homology with the N-terminal domain of the DNA fragmentation factor (DFF).
Sterol-regulatory-element-binding protein 1c mediates the effect of insulin on the expression of Cidea in mouse hepatocytes.
GeneRIF
Chang et al., Beijing, China. In Biochem J, 2010
SREBP-1c mediates the effect of insulin on the expression of Cidea in mouse hepatocytes.
Peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) stimulates VLDL assembly through activation of cell death-inducing DFFA-like effector B (CideB).
GeneRIF
Finck et al., Saint Louis, United States. In J Biol Chem, 2010
PGC-1alpha plays an important role in partitioning cytoplasmic TG toward the VLDL secretory compartments and promoting VLDL secretion via transcriptional induction of CideB.
Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb.
GeneRIF
Li et al., Beijing, China. In Biochim Biophys Acta, 2010
Data suggest that Cideb is a novel regulator in controlling cholesterol homeostasis in the liver.
CIDE proteins and metabolic disorders.
Review
Li et al., Beijing, China. In Curr Opin Lipidol, 2009
PURPOSE OF REVIEW: The cell death-inducing DFF45-like effector (CIDE) family proteins, comprising three members, Cidea, Cideb, and Fsp27 (Cidec), have emerged as important regulators for various aspects of metabolism.
Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B.
Impact
GeneRIF
Li et al., Beijing, China. In Cell Metab, 2009
Cideb protein promotes the formation of triacylglycerol-enriched VLDL particles and provides a molecular insight into VLDL lipidation and maturation in hepatocytes.
Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation.
GeneRIF
Li et al., Hong Kong, Hong Kong. In Diabetes, 2007
Cideb is a novel important regulator in lipid metabolism in the liver and may thus represent a new therapeutic target for the treatment of obesity, diabetes, and liver steatosis
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