Kinetics of gene derepression by ERK signaling.
Princeton, United States. In Proc Natl Acad Sci U S A, 2013
ERK induces ind by antagonizing its repression by Capicua (Cic), a transcription factor that acts as a sensor of receptor tyrosine kinases in animal development and human diseases.
EGFR-dependent downregulation of Capicua and the establishment of Drosophila dorsoventral polarity.
Barcelona, Spain. In Fly (austin), 2012
We have characterized the transcriptional circuit that links EGFR signaling to pipe repression: in dorsal follicle cells, the homeodomain transcription factor Mirror (Mirr), which is induced by EGFR signaling, directly represses pipe transcription, whereas in ventral follicle cells, the HMG-box protein Capicua (Cic) supports pipe expression by repressing mirr.
Mutations in CIC and FUBP1 contribute to human oligodendroglioma.
Baltimore, United States. In Science, 2011
CIC gene was mutated in 6 oligodendrogliomas and FUBP1 gene was mutated in 2; 27 additional oligodendrogliomas showed 12 and 3 more tumors with mutations of CIC and FUBP1; results suggest role of these genes in biology and pathology of oligodendrocytes