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Cytokine induced apoptosis inhibitor 1

CIAPIN1, DRE2, Anamorsin, Cytokine-induced apoptosis inhibitor 1
CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, OUT, CIA, bcl-2
Papers on CIAPIN1
Knock-down of CIAPIN1 sensitizes K562 chronic myeloid leukemia cells to Imatinib by regulation of cell cycle and apoptosis-associated members via NF-κB and ERK5 signaling pathway.
New
Pang et al., Tianjin, China. In Biochem Pharmacol, Feb 2016
CIAPIN1 (cytokine-induced apoptosis inhibitor 1) was recently identified as an essential downstream effector of the Ras signaling pathway.
Elucidating the Molecular Function of Human BOLA2 in GRX3-Dependent Anamorsin Maturation Pathway.
New
Muzzioli et al., Sesto Fiorentino, Italy. In J Am Chem Soc, Jan 2016
To investigate the still unknown functional role of the interaction between human glutaredoxin-3 (GRX3) and its protein partner BOLA2, we characterized at the atomic level the interaction of apo BOLA2 with the apo and holo states of GRX3 and studied the role of BOLA2 in the GRX3-dependent anamorsin maturation pathway.
[Expression of cytokine-induced apoptosis inhibitor 1 in gastric cancer tissues and its effects on invasion and migration of SGC-7901 cell].
New
Fan et al., Xi'an, China. In Zhonghua Wei Chang Wai Ke Za Zhi, Sep 2015
OBJECTIVE: To examine the expression of cytokine-induced apoptosis inhibitor1 (CIAPIN1) in gastric cancer and normal mucosa tissues, and to investigate its effects on migration and invasion of gastric cancer cells.
Cytokine-induced apoptosis inhibitor 1 inhibits the growth and proliferation of multiple myeloma.
New
Li et al., Guangzhou, China. In Mol Med Report, Aug 2015
The present study investigated the differential expression of cytokine-induced apoptosis inhibitor 1 (CIAPIN1) in human multiple myeloma (MM) bone marrow tissue and adjacent healthy bone marrow tissue.
CIAPIN1 targets Na⁺/H⁺ exchanger 1 to mediate MDA-MB-231 cells' metastasis through regulation of MMPs via ERK1/2 signaling pathway.
New
Pang et al., Tianjin, China. In Exp Cell Res, May 2015
Cytokine-induced antiapoptotic inhibitor 1 (CIAPIN1) was recently identified as an essential downstream effector of the Ras signaling pathway and has been confirmed to be closely associated with various malignant tumors.
CIAPIN1 and ABCA13 are markers of poor survival in metastatic ovarian serous carcinoma.
Davidson et al., Oslo, Norway. In Mol Cancer, 2014
METHODS: Advanced-stage serous ovarian carcinoma effusions (n = 150) were analyzed for mRNA expression of AKR1C1, ABCA4, ABCA13, ABCB10, BIRC6, CASP9, CIAPIN1, FAS, MGMT, MUTYH, POLH, SRC, TBRKB and XPA using quantitative real-time PCR.
Cancer-Related NEET Proteins Transfer 2Fe-2S Clusters to Anamorsin, a Protein Required for Cytosolic Iron-Sulfur Cluster Biogenesis.
Jennings et al., Denton, United States. In Plos One, 2014
Here we report the first physiological 2Fe-2S cluster acceptor for both NEET proteins as human Anamorsin (also known as cytokine induced apoptosis inhibitor-1; CIAPIN-1).
The diabetes drug target MitoNEET governs a novel trafficking pathway to rebuild an Fe-S cluster into cytosolic aconitase/iron regulatory protein 1.
Bouton et al., Gif-sur-Yvette, France. In J Biol Chem, 2014
Here we show that Fe-S assembly of mitoNEET, the first identified Fe-S protein anchored in the mitochondrial outer membrane, strictly depends on ISC machineries and not on the CIA or CIAPIN1.
Epigenetic role for the conserved Fe-S cluster biogenesis protein AtDRE2 in Arabidopsis thaliana.
Kinoshita et al., Nara, Japan. In Proc Natl Acad Sci U S A, 2014
We used an FWA-GFP reporter to find mutants defective in maternal activation of FWA-GFP in the EDL, and isolated an allele of the yeast Dre2/human antiapoptotic factor CIAPIN1 homolog, encoding an enzyme previously implicated in the cytosolic Fe-S biogenesis pathway (CIA), which we named atdre2-2.
CIAPIN1 targets Na+/H+ exchanger 1 to mediate K562 chronic myeloid leukemia cells' differentiation via ERK1/2 signaling pathway.
Pang et al., Tianjin, China. In Leuk Res, 2014
CIAPIN1 (cytokine-induced antiapoptotic inhibitor 1) was recently identified as an essential downstream effector of the Ras signaling pathway.
Anamorsin, a novel caspase-3 substrate in neurodegeneration.
Oh et al., Seoul, South Korea. In J Biol Chem, 2014
Among 46 putative substrates identified in MN9D neuronal cells, we further evaluated whether caspase-3-mediated cleavage of anamorsin, a recently recognized cell death-defying factor in hematopoiesis, is a general feature of apoptosis.
Discovery, isolation, and structure elucidation of dretamycin.
Roemer et al., Rahway, United States. In J Nat Prod, 2014
MS-1-4 was discovered to produce a compound, dretamycin, which yielded a fitness profile exhibiting significant hypersensitivity of the DRE2 heterozygote and hyposensitivity of the DIP5 heterozygote.
[Effect of CIAPIN1 gene on proliferation of K562 cells].
Pang et al., Tianjin, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2014
The study was aimed to investigate the effect of CIAPIN1 gene on the proliferation of chronic myeloid leukemia (CML) cell line K562.
CIAPIN1 gene silencing enhances chemosensitivity in a drug-resistant animal model in vivo.
Lu et al., Harbin, China. In Braz J Med Biol Res, 2014
Overexpression of cytokine-induced apoptosis inhibitor 1 (CIAPIN1) contributes to multidrug resistance (MDR) in breast cancer.
A S-adenosylmethionine methyltransferase-like domain within the essential, Fe-S-containing yeast protein Dre2.
GeneRIF
Vernis et al., Orsay, France. In Febs J, 2012
Study show that Dre2 contains an N-terminal domain whose structure in solution consists of a stable well-structured monomer with an overall typical S-adenosylmethionine methyltransferase fold lacking two alpha-helices and a beta-strand.
Investigation of in vivo diferric tyrosyl radical formation in Saccharomyces cerevisiae Rnr2 protein: requirement of Rnr4 and contribution of Grx3/4 AND Dre2 proteins.
GeneRIF
Huang et al., Cambridge, United States. In J Biol Chem, 2012
diferric tyrosyl radical formation in Saccharomyces cerevisiae Rnr2 protein: requirement of Rnr4 and contribution of Grx3/4 AND Dre2 proteins.(
Interaction between the reductase Tah18 and highly conserved Fe-S containing Dre2 C-terminus is essential for yeast viability.
GeneRIF
Vernis et al., Orsay, France. In Mol Microbiol, 2011
Interaction between the Tah18 and Dre2 C-terminus is essential for viability.
Anamorsin is a [2Fe-2S] cluster-containing substrate of the Mia40-dependent mitochondrial protein trapping machinery.
GeneRIF
Winkelmann et al., Sesto Fiorentino, Italy. In Chem Biol, 2011
Anamorsin is a Mia40-dependent but ALR-independent IMS-protein and binds a [2Fe-2S] cluster before and after specific Mia40-driven Cys-oxidation.
[Expression of CIAPIN1 gene in BMMNC of patients with leukemia].
GeneRIF
Pang et al., Tianjin, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2011
Up-regulation of CIAPIN1 expression may play an important role in pathogenesis of leukemia.
CIAPIN1 as a therapeutic target in cancer.
Review
Fan et al., Xi'an, China. In Expert Opin Ther Targets, 2010
IMPORTANCE OF THE FIELD: Cytokine-induced apoptosis inhibitor 1 (CIAPIN1) is a newly identified cytokine-induced apoptosis inhibitor, which has roles in cell division and angiogenesis.
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