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Baculoviral IAP repeat containing 3
cIAP2, cIAP1, API2
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011] (from
... and MS-581-P) was from Neomarkers (Fremont, CA, USA), anti-p100 (05-361) from Millipore (Temecula, CA, USA), anti-cIAP2 (51-9000062) was from BD (Heidelberg, Germany), and anti-NIK (4994), anti-rabbitHRP (7074) and anti-pIκBα (S32, 2859L) were from Cell Signaling Technologies (Danvers, MA, USA) ...