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Baculoviral IAP repeat containing 3

cIAP2, cIAP1, API2
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011] (from NCBI)
Papers using cIAP2 antibodies
Interaction of insulin-like growth factor-binding protein-3 and BAX in mitochondria promotes male germ cell apoptosis.
Mayer Claudine, In PLoS ONE, 2009
... Antibodies against survivin, c-IAP1, and c-IAP2 were from Santa Cruz Biotechnology, Inc ...
The IKK2/NF-{kappa}B pathway suppresses MYC-induced lymphomagenesis
Siegmund D et al., In Cell Death & Disease, 2008
... and MS-581-P) was from Neomarkers (Fremont, CA, USA), anti-p100 (05-361) from Millipore (Temecula, CA, USA), anti-cIAP2 (51-9000062) was from BD (Heidelberg, Germany), and anti-NIK (4994), anti-rabbitHRP (7074) and anti-pIκBα (S32, 2859L) were from Cell Signaling Technologies (Danvers, MA, USA) ...
Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins
Streuli Charles H et al., In Breast Cancer Research : BCR, 2007
... The following primary antibodies were used: cIAP2 and Desmoplakin (Abcam, Cambridge, UK); monoclonal XIAP ...
Derivation of embryonic stem cell lines.
Green Douglas R., In PLoS Biology, 1992
... Myc-tagged murine c-IAP1 was obtained by subcloning into pCMV-Tag5 (Clontech).
Papers on cIAP2
BIRC2 amplification in squamous cell carcinomas of the uterine cervix.
Simon et al., Hamburg, Germany. In Virchows Arch, 2012
BIRC2 is amplified in a subset of squamous cell carcinoma of the uterine cervix.
Src, Akt, NF-κB, BCL-2 and c-IAP1 may be involved in an anti-apoptotic effect in patients with BCR-ABL positive and BCR-ABL negative acute lymphoblastic leukemia.
Lezama et al., Mexico. In Leuk Res, 2012
Src, Akt, NF-kappaB, BCL-2 and c-IAP1 may be involved in an anti-apoptotic effect in patients with BCR-ABL positive and BCR-ABL negative acute lymphoblastic leukemia.
Critical role for antiapoptotic Bcl-xL and Mcl-1 in human macrophage survival and cellular IAP1/2 (cIAP1/2) in resistance to HIV-Vpr-induced apoptosis.
Kumar et al., Ottawa, Canada. In J Biol Chem, 2012
resistance to Vpr-induced apoptosis is specifically mediated by cIAP1/2 genes independent of Bcl-xL and Mcl-1, which play a key role in maintaining cell viability.
An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1.
Duckett et al., Ann Arbor, United States. In Biochem J, 2012
found that, despite extensive backcrossing into a C57BL/6 background, c-IAP1(-/-) animals are also deficient in caspase 11
Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors.
Vucic et al., San Francisco, United States. In Sci Signal, 2012
c-IAP1 and c-IAP2 were required for canonical activation of NF-B and MAPK by members of the TNFR family.
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