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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ASF1 anti-silencing function 1 homolog A

CIA
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Interleukin-6, IL-17, CAN, V1a, HAD
Papers on CIA
Induction of Tolerance against the Arthritogenic Antigen with Type-II Collagen Peptide-Linked Soluble MHC Class II Molecules.
New
Park et al., Seoul, South Korea. In Bmb Rep, Feb 2016
UNASSIGNED: In murine collagen-induced arthritis (CIA), self-reactive T cells recognize peptide antigens derived from type-II collagen (CII).
Suppression of experimental arthritis and associated bone loss by a tissue-selective estrogen complex.
New
Islander et al., Göteborg, Sweden. In Endocrinology, Feb 2016
Female ovariectomized DBA/1 mice were subjected to collagen-induced arthritis (CIA), an experimental postmenopausal RA model, and treated with BZA, 17β-estradiol (E2), combined BZA and E2 (BZA/E2) or vehicle.
Effects and mechanisms of potent caspase-1 inhibitor VX765 treatment on collagen-induced arthritis in mice.
New
Zheng et al., Beijing, China. In Clin Exp Rheumatol, Feb 2016
In this study we investigated the effect of VX765 treatment on collagen-induced arthritis (CIA).
Antiarthritis Effect of Morin is Associated with Inhibition of Synovial Angiogensis.
New
Wei et al., Nanjing, China. In Drug Dev Res, Dec 2015
This study investigated its effect on type II collagen-induced arthritis (CIA) in rats and explored the underlying mechanisms in view of synovial angiogenesis.
A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation.
New
Blease et al., Matsumoto, Japan. In Plos One, Dec 2015
Moreover, CC-509 significantly reduced paw swelling and the tissue levels of pro-inflammatory cytokines RANTES and MIP-1α in the collagen-induced arthritis (CIA) model.
Immunological GABAergic interactions and therapeutic applications in autoimmune diseases.
Review
New
Wang et al., Toronto, Canada. In Autoimmun Rev, Nov 2015
In preclinical models, therapeutic application of GABA, or GABAergic (agonistic) drugs, protects against type 1 diabetes (T1D), experimental autoimmune encephalomyelitis (EAE), collagen-induced arthritis (CIA) and contact dermatitis.
Experimental and investigational therapies for chemotherapy-induced anemia.
Review
New
Elvira et al., Roma, Italy. In Expert Opin Investig Drugs, Nov 2015
INTRODUCTION: In cancer patients, anemia is frequently observed, particularly as a consequence to chemotherapy (chemotherapy-induced anemia, CIA).
The role of mitochondria and the CIA machinery in the maturation of cytosolic and nuclear iron-sulfur proteins.
Review
New
Mühlenhoff et al., Marburg an der Lahn, Germany. In Eur J Cell Biol, Jul 2015
The sulfur-containing compound is exported by the mitochondrial ABC transporter Atm1 (human ABCB7) and utilized by components of the cytosolic iron-sulfur protein assembly (CIA) machinery.
From the worm to the pill, the parasitic worm product ES-62 raises new horizons in the treatment of rheumatoid arthritis.
Review
New
Harnett et al., Glasgow, United Kingdom. In Lupus, Apr 2015
ES-62 is a secreted glycoprotein of the filarial nematode Acanthocheilonema viteae, which we have found to protect against the development of collagen-induced arthritis (CIA) in mice.
Molecular mechanisms of pain in crystal-induced arthritis.
Review
New
Punzi et al., Padova, Italy. In Best Pract Res Clin Rheumatol, Feb 2015
Crystal-induced arthritis (CIA) is characterized by an intense inflammatory reaction triggered by the deposition of monosodium urate, calcium pyrophosphate, and basic calcium phosphate crystals in articular and periarticular tissues.
Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.
Impact
Lill et al., Marburg an der Lahn, Germany. In Cell Metab, 2013
Here, we identify and characterize human CIA2A (FAM96A), CIA2B (FAM96B), and CIA1 (CIAO1) as components of the cytosolic Fe/S protein assembly (CIA) machinery.
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.
Impact
Lill et al., Marburg an der Lahn, Germany. In Science, 2012
Here, we identify MMS19 as a member of the cytosolic iron-sulfur protein assembly (CIA) machinery.
MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.
Impact
Boulton et al., London, United Kingdom. In Science, 2012
Here, we demonstrate that MMS19 forms a complex with the cytoplasmic Fe-S assembly (CIA) proteins CIAO1, IOP1, and MIP18.
Dynamics and memory of heterochromatin in living cells.
Impact
Crabtree et al., Stanford, United States. In Cell, 2012
To address these questions, we developed a chromatin in vivo assay (CiA) system employing chemically induced proximity to initiate and terminate chromatin modifications in living cells.
Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply.
GeneRIF
Groth et al., Copenhagen, Denmark. In Embo J, 2012
The authors propose that Codanin-1 acts as a negative regulator of Asf1 function in chromatin assembly.
Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex.
GeneRIF
Marmorstein et al., Philadelphia, United States. In Biochemistry, 2012
NHRD domain of UBN1 as being an essential region for HIRA interaction and chromatin organization by the HUCA complex
Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R.
GeneRIF
Slagboom et al., Leiden, Netherlands. In Plos One, 2011
Low ASF1A is associated with familial longevity.
Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex.
GeneRIF
Adams et al., Bearsden, United Kingdom. In Mol Cell Biol, 2011
Data show that, like HIRA, UBN1, and ASF1a, CABIN1 is involved in heterochromatinization of the genome of senescent human cells.
A CD40 and an NCOA5 gene polymorphism confer susceptibility to psoriasis in a Southern European population: a case-control study.
GeneRIF
Krueger-Krasagakis et al., Irákleion, Greece. In Hum Immunol, 2011
gene polymorphism confers susceptibility to psoriasis in a Southern European population
Targeted depletion of lymphotoxin-alpha-expressing TH1 and TH17 cells inhibits autoimmune disease.
Impact
Grogan et al., San Francisco, United States. In Nat Med, 2009
In collagen-induced arthritis (CIA), preventive and therapeutic administration of LT-alpha-specific mAb inhibited disease, and immunoablated T cells expressing interleukin-17 (IL-17), interferon-gamma and tumor necrosis factor-alpha (TNF-alpha), whereas decoy lymphotoxin-beta receptor (LT-betaR) fusion protein had no effect.
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