Nidovirales: evolving the largest RNA virus genome.
Leiden, Netherlands. In Virus Res, 2006
Replicase gene expression is under the principal control of a ribosomal frameshifting signal and a chymotrypsin-like protease, which is assisted by one or more papain-like proteases.
Secreted proteases from pathogenic fungi.
Lausanne, Switzerland. In Int J Med Microbiol, 2002
To these proteases has to be added the non-pepsin-type aspartic protease from Aspergillus niger and a unique chymotrypsin-like protease from Coccidioides immitis.
A new myocardial conversion of angiotensin I.
Winston-Salem, United States. In Curr Opin Cardiol, 1994
An alternative pathway for the generation of angiotensin II from angiotensin I has been proposed, following the recent identification of a chymotrypsin-like protease (chymase) that may contribute to the formation of angiotensin II in human heart tissue.
Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B.
Martinsried, Germany. In Nature, 1993
Here we report that I kappa B-alpha (formerly MAD-3) is degraded in cells after stimulation with phorbol ester, interleukin-1, lipopolysaccharide and tumour necrosis factor-alpha, an event coincident with the appearance of active NF-kappa B. Treatment of cells with various protease inhibitors or an antioxidant completely prevented the inducible decay of I kappa B-alpha as well as the activation of NF-kappa B. Our findings suggest that the activation of NF-kappa B relies on an inducible degradation of I kappa B-alpha through a cytoplasmic, chymotrypsin-like protease.