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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Chymotrypsin-like

chymotrypsin-like protease
pancreatic digestive serine protease [RGD, Feb 2006] (from NCBI)
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Top mentioned proteins: Chymotrypsin, Trypsin, HAD, ACID, CAN
Papers on chymotrypsin-like protease
Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV.
New
Ryu et al., South Korea. In J Enzyme Inhib Med Chem, Feb 2016
Two viral proteases of severe acute respiratory syndrome coronavirus (SARS-CoV), a chymotrypsin-like protease (3CL(pro)) and a papain-like protease (PL(pro)) are attractive targets for the development of anti-SARS drugs.
Structural basis for the development of SARS 3CL protease inhibitors from a peptide mimic to an aza-decaline scaffold.
New
Akaji et al., Sendai, Japan. In Biopolymers, Dec 2015
UNASSIGNED: Design of inhibitors against severe acute respiratory syndrome (SARS) chymotrypsin-like protease (3CL(pro) ) is a potentially important approach to fight against SARS.
Impact of Q139R substitution of MEB4-Cry2Aa toxin on its stability, accessibility and toxicity against Ephestia kuehniella.
New
Souad et al., Sfax, Tunisia. In Int J Biol Macromol, Nov 2015
In fact, due to its presence within the loop α3-α4, the chymotrypsin-like protease was unable to access to its site in Cry2Aa-MEB4, resulting to the production of only the 65kDa form.
Structures of DegQ from Legionella pneumophila Define Distinct ON and OFF States.
New
Hansen et al., Lübeck, Germany. In J Mol Biol, Sep 2015
A common feature of all members of this family is their modular organization comprising a chymotrypsin-like protease domain and at least one PDZ (postsynaptic density of 95 kDa, disks large homolog 1 and zonula occludens 1) domain.
[Preliminary Genetic and Functional Analyses of Schistosoma japonicum Chymotrypsin-like Protease].
New
Hu et al., In Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi, Aug 2015
OBJECTIVE: To investigate the gene expression, localization and potential functions of Schistosoma japonicum chymotrypsin-like protease (SjCTRL) in the host, and evaluate its potential immune-protection efficacy against S. japonicum infection in mice.
Handicap-Recover Evolution Leads to a Chemically Versatile, Nucleophile-Permissive Protease.
New
Hollfelder et al., Melbourne, Australia. In Chembiochem, Jul 2015
This apparent nucleophile permissiveness explains how nucleophile switches can occur in the phylogeny of the chymotrypsin-like protease PA superfamily.
Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors.
New
Akaji et al., Kyoto, Japan. In Bioorg Med Chem, Mar 2015
The design and evaluation of a novel decahydroisoquinolin scaffold as an inhibitor for severe acute respiratory syndrome (SARS) chymotrypsin-like protease (3CL(pro)) are described.
Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: homology modelling and molecular dynamic studies.
Gamieldien et al., Cape Town, South Africa. In Bmc Struct Biol, 2014
BACKGROUND: The coronavirus 3 chymotrypsin-like protease (3CL(pro)) is a validated target in the design of potential anticoronavirus inhibitors.
Analysis of the complete genomic sequences of two virus subpopulations of the Australian infectious bronchitis virus vaccine VicS.
Browning et al., Melbourne, Australia. In Avian Pathol, 2014
Compared with VicS-v, the more attenuated VicS-del strain had two non-synonymous changes in the non-structural protein 6 (nsp6), a transmembrane (TM) domain that may participate in autocatalytic release of the 3-chymotrypsin-like protease, a polymorphic difference at the end of the S2 gene, which coincided with the body transcription-regulating sequence (B-TRS) of mRNA 3 and a truncated open reading frame for a peptide encoded by gene 4 (4b).
Characterization of Treponema denticola mutants defective in the major antigenic proteins, Msp and TmpC.
Yoshimura et al., Nagoya, Japan. In Plos One, 2013
Msp defects increased cell-surface hydrophobicity and secretion of TNF-α from macrophage-like cells, whereas TmpC defects decreased autoagglutination and chymotrypsin-like protease activities.
Chymotrypsin-like protease (chymase) mediates endothelial activation by factors derived from preeclamptic placentas.
GeneRIF
Yuping Wang et al., Shreveport, United States. In Reprod Sci, 2009
activation of endothelial CLP/chymase may directly relate to the increased inflammatory phenotypic changes in the vascular system in women with preeclampsia
Placenta-derived chymotrypsin-like protease (CLP) disturbs endothelial junctional structure in preeclampsia.
GeneRIF
Wang et al., Shreveport, United States. In Reprod Sci, 2009
Placenta-derived chymotrypsin-like protease contributes to the altered endothelial barrier function in preeclampsia.
Nidovirales: evolving the largest RNA virus genome.
Review
Snijder et al., Leiden, Netherlands. In Virus Res, 2006
Replicase gene expression is under the principal control of a ribosomal frameshifting signal and a chymotrypsin-like protease, which is assisted by one or more papain-like proteases.
Molecular cloning and characterization of chymopasin, a novel serine protease from rat pancreas.
GeneRIF
Yamaguchi et al., Kyoto, Japan. In Pancreas, 2002
molecular cloning and characterization of chymopasin from the pancreas [chymopasin]
Secreted proteases from pathogenic fungi.
Review
Jousson et al., Lausanne, Switzerland. In Int J Med Microbiol, 2002
To these proteases has to be added the non-pepsin-type aspartic protease from Aspergillus niger and a unique chymotrypsin-like protease from Coccidioides immitis.
Co-translational folding of an alphavirus capsid protein in the cytosol of living cells.
Impact
Helenius et al., Zürich, Switzerland. In Nat Cell Biol, 1999
The Semliki Forest virus capsid protein contains a chymotrypsin-like protease domain that must fold before it can autocatalytically cleave the protein from a larger polyprotein precursor.
A new myocardial conversion of angiotensin I.
Review
Chappell et al., Winston-Salem, United States. In Curr Opin Cardiol, 1994
An alternative pathway for the generation of angiotensin II from angiotensin I has been proposed, following the recent identification of a chymotrypsin-like protease (chymase) that may contribute to the formation of angiotensin II in human heart tissue.
Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B.
Impact
Baeuerle et al., Martinsried, Germany. In Nature, 1993
Here we report that I kappa B-alpha (formerly MAD-3) is degraded in cells after stimulation with phorbol ester, interleukin-1, lipopolysaccharide and tumour necrosis factor-alpha, an event coincident with the appearance of active NF-kappa B. Treatment of cells with various protease inhibitors or an antioxidant completely prevented the inducible decay of I kappa B-alpha as well as the activation of NF-kappa B. Our findings suggest that the activation of NF-kappa B relies on an inducible degradation of I kappa B-alpha through a cytoplasmic, chymotrypsin-like protease.
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