Revisiting the role of the mast cell in asthma.
Lund, Sweden. In Curr Opin Pulm Med, Jan 2016
RECENT FINDINGS: The heterogeneity of human mast cells has been recognized: MCTC expressing both tryptase and chymase and MCT expressing tryptase only.
Phenotypic variability in human skin mast cells.
Berlin, Germany. In Exp Dermatol, Jan 2016
Pathophysiologically relevant key features were quantified and correlated: transcripts of c-kit, FcεRIα, FcεRIβ, FcεRIγ, histidine decarboxylase, tryptase, and chymase; surface expression of c-Kit, FcεRIα; activity of tryptase, and chymase; histamine content and release triggered by FcεRI and Ca(2+) ionophore.
Emerging small-molecule compounds for treatment of atopic dermatitis: a review.
Hradec Králové, Czech Republic. In Expert Opin Ther Pat, Nov 2015
These substances include compounds targeting the skin barrier (filaggrin production promoters, filaggrin breakdown products and compounds improving stratum corneum lipid barrier including pseudoceramides), anti-inflammatory compounds (PDE4/7 inhibitors, CRTH2 inhibitors, chemokine receptor antagonists, inhibitors of chymase and other) and compounds specifically targeting itch (TRP agonists, opioid ligands, serotonin 7 and histamine 4 antagonists).
Role of chymase in diabetic nephropathy.
São Paulo, Brazil. In Exp Biol Med (maywood), 2012
The results indicate an important role for chymase in inducing fibrosis through TGF-beta1 activation, parallel with Ang II effects.