Revisiting the role of the mast cell in asthma.
Lund, Sweden. In Curr Opin Pulm Med, Jan 2016
RECENT FINDINGS: The heterogeneity of human mast cells has been recognized: MCTC expressing both tryptase and chymase and MCT expressing tryptase only.
Phenotypic variability in human skin mast cells.
Berlin, Germany. In Exp Dermatol, Jan 2016
Pathophysiologically relevant key features were quantified and correlated: transcripts of c-kit, FcεRIα, FcεRIβ, FcεRIγ, histidine decarboxylase, tryptase, and chymase; surface expression of c-Kit, FcεRIα; activity of tryptase, and chymase; histamine content and release triggered by FcεRI and Ca(2+) ionophore.
Human heart as a shock organ in anaphylaxis.
Napoli, Italy. In Allergo J Int, 2013
Anti-IgE, anti-FcεRI, and immunoglobulin superallergens induce in vitro secretion of preformed mediators (histamine, tryptase, chymase, and renin) and the de novo synthesis of cysteinyl leukotriene C4 (LTC4) and prostaglandin D2 (PGD2) from HHMC.
Role of chymase in diabetic nephropathy.
São Paulo, Brazil. In Exp Biol Med (maywood), 2012
The results indicate an important role for chymase in inducing fibrosis through TGF-beta1 activation, parallel with Ang II effects.