GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Chromogranin A
chromogranin A, CgA, pancreastatin
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
Synaptophysin, HAD, CAN, AGE, fibrillin-1
Papers using
chromogranin A
antibodies
Additive actions of the cannabinoid and neuropeptide Y systems on adiposity and lipid oxidation
Supplier
In Cell Metabolism, 2009
... (Chemicon, Harrow, UK), DAPI (Sigma-Aldrich, Poole, UK), PGP9.5 (Ultraclone Ltd., Isle of Wight, UK), and chromogranin A (DAKO A/S, Glostrup, Denmark) were ...
Temozolomide as monotherapy is effective in treatment of advanced malignant neuroendocrine tumors
Supplier
In The Scientific World Journal, 2006
... Polyclonal Rabbit Anti-Human Chromogranin A (Dako Denmark A/S, Glostrup, Denmark) ...
A case of primary small cell carcinoma of the breast
Supplier
In Pathology Research International, 2006
... CD99 (Dako, clone 12E7, 1 : 100), NSE (Dako, clone BBS/NC/VIH14, 1 : 500), synaptophysin (Novocastra, clone 27G12, 1 : 150), chromogranin A (Dako, clone DAK-A3, 1 : 3000), high ...
Small-cell carcinoma of the gastrointestinal tract: a retrospective study of 64 cases
Supplier
In Diagnostic Pathology, 2003
... Chromogranin APolyclonalDako (Carpinteria, CA) ...
The gastric cardia: fact or fiction?
more suppliersSupplier
In Gastroenterology Research and Practice, 1999
... Glostrup, Denmark, 1 : 200) and HDC (Code B260-1, Eurodiagnostica, 1 : 15000) for 1 hour at room temperature, and CgA (Code MO869, Dakocytomation, 1 : 2000) and serotonin (Code 6336, Abcam, 1 : 100) for 18 hours ...
Papers on
chromogranin A
Chromogranin A: any relevance in neuroendocrine tumors?
Review
New
New Haven, United States. In Curr Opin Endocrinol Diabetes Obes, Feb 2016
PURPOSE OF REVIEW: The review summarizes the utility and limitations of chromogranin A (CgA) as a circulating biomarker for neuroendocrine tumors (NETs).
The New Combination Docetaxel, Prednisone and Curcumin in Patients with Castration-Resistant Prostate Cancer: A Pilot Phase II Study.
New
Clermont-Ferrand, France. In Oncology, Feb 2016
An ancillary study assessed the seric values of chromogranin A (CgA) and neuron-specific enolase (NSE).
Influence of abiraterone acetate on circulating neuromediators in chemotherapy-naïve castration-resistant prostate cancer.
New
Mannheim, Germany. In Prostate, Feb 2016
We evaluated how treatment with AA influences circulating neuromediators chromogranin A (CGA), neuron-specific enolase (NSE), and pro-gastrin-releasing peptide (Pro-GRP) in chemotherapy-naïve CRPC patients.
PROX1 promotes secretory granule formation in medullary thyroid cancer cells.
New
Kami-renjaku, Japan. In Endocrinology, Feb 2016
Knockdown of PROX1 in an MTC cells reduced SGs detected by electron microscopy, and decreased expression of SG-related genes (Chromogranin A, Chromogranin B, Secretogranin II, Secretogranin III, Synaptophysin and Carboxypeptidase E).
Columnar Metaplasia in the Esophageal Remnant After Esophagectomy: A Common Occurrence and a Valuable Insight Into the Development of Barrett Esophagus.
New
Newcastle upon Tyne, United Kingdom. In Ann Surg, Feb 2016
Specimens were stained using hematoxylin and eosin and by immunohistochemistry for cytokeratins 7 and 20, and Chromogranin A-proteins which have a well described expression pattern in sporadic Barrett esophagus.
Microcystic/Reticular Schwannoma of the Mandible First Case Report and Review of the Literature.
Review
New
Shanghai, China. In Medicine (baltimore), Nov 2015
Tumor cells were also positive for CD34, CD99, and NSE, but negative for CK, EMA, CK5/6, P63, Calponin, CD10, SMA, Desmin, GFAP, NF, Syn, and CgA.
[Primary Carcinoid Tumor of the Urinary Bladder : A Case Report and Questionnaire Survey on the Reported Cases in Japan].
Review
New
Davao, Philippines. In Hinyokika Kiyo, Nov 2015
An immunohistochemical study showed the tumor cells were positively stained for chromogranin A, synaptophysin, CD56, and NSE.
Duodenal gangliocytic paraganglioma: report of two cases and review of literature.
Review
China. In Int J Clin Exp Pathol, 2014
The epithelioid cells were positive for cytokeratin (AE1/AE3), synaptophysin (Syn), chromogranin A (CgA), CD56 and progesterone receptor (PR).
Unusual paraneoplastic neurological syndrome secondary to a well differentiated pancreatic neuroendocrine tumor: a case report and review of the literature.
Review
Torino, Italy. In Bmc Cancer, 2014
Initial treatment with long-acting somatostatin analogue (octreotide LAR) and prednisone achieved a biochemical response (reduction of chromogranin A level) and a radiological disease control, but patient experienced only a brief improvement of neurological symptoms.
Chromogranin A and cortisol at intraoperative repeated noxious stimuli: Surgical stress in a dog model.
Uppsala, Sweden. In Sage Open Med, 2014
CONCLUSION: The results suggest chromogranin A is a poor indicator of intraoperative sympathetic tone during elective surgery in dogs.
Circulating tumor cells as prognostic markers in neuroendocrine tumors.
Impact
London, United Kingdom. In J Clin Oncol, 2013
Presence of CTCs was associated with increased burden, increased tumor grade, and elevated serum chromogranin A (CgA).
Antiarrhythmic effects of vasostatin-1 in a canine model of atrial fibrillation.
GeneRIF
Oklahoma City, United States. In J Cardiovasc Electrophysiol, 2012
Vasostatin-1 suppresses atrial fibrillation inducibility, likely by inhibiting ganglionated plexus function.
Differences of molecular expression mechanisms among neural cell adhesion molecule 1, synaptophysin, and chromogranin A in lung cancer cells.
GeneRIF
Yokohama, Japan. In Pathol Int, 2012
NCAM1, SYPT and CGA expressions are differently regulated by neuroendocrine phenotype-specific transcription factors in lung cancer cells.
Chromogranin A is a reliable biomarker for gastroenteropancreatic neuroendocrine tumors in an Asian population of patients.
GeneRIF
Taiwan. In Neuroendocrinology, 2011
Chromogranin A is a reliable biomarker for gastroenteropancreatic neuroendocrine tumors.
Chromogranin A (CgA) as poor prognostic factor in patients with small cell carcinoma of the cervix: results of a retrospective study of 293 patients.
GeneRIF
Guangzhou, China. In Plos One, 2011
CgA may serve as a useful marker in prognostic evaluation for early-stage patients with small cell carcinoma of the cervix.
The extended granin family: structure, function, and biomedical implications.
Review
Impact
Minneapolis, United States. In Endocr Rev, 2011
The chromogranins (chromogranin A and chromogranin B), secretogranins (secretogranin II and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) that together comprise the granin family subserve essential roles in the regulated secretory pathway that is responsible for controlled delivery of peptides, hormones, neurotransmitters, and growth factors.
Correlation between age and Chromogranin A determination in prostate diseases.
GeneRIF
Perugia, Italy. In Cancer Biomark, 2010
Data indicate that Chromogranin A (CgA values did not correlate with other clinical prognostic factors, except age, in untreated-naive prostate cancer (PC).
Chromogranin A is an autoantigen in type 1 diabetes.
Impact
Denver, United States. In Nat Immunol, 2010
In the nonobese diabetic (NOD) mouse model of type 1 diabetes, we have identified the peptide WE14 from chromogranin A (ChgA) as the antigen for highly diabetogenic CD4(+) T cell clones.
Daily oral everolimus activity in patients with metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: a phase II trial.
Impact
Houston, United States. In J Clin Oncol, 2010
Chromogranin A (CgA) and neuron-specific enolase (NSE) were assessed monthly if elevated at baseline.
Phase II study of high-dose [131I]metaiodobenzylguanidine therapy for patients with metastatic pheochromocytoma and paraganglioma.
More papers using
chromogranin A
antibodies
Impact
San Francisco, United States. In J Clin Oncol, 2009
Response was evaluated by [(123)I]MIBG scans, computed tomography/magnetic resonance imaging, urinary catecholamines/metanephrines, and chromogranin A. RESULTS: The overall complete response (CR) plus partial response (PR) rate in 49 evaluable patients was 22%.
Abnormal enteric nerve morphology in atretic esophagus of fetal rats with adriamycin-induced esophageal atresia
Supplier
In International Journal of Pediatrics, 1998
... (6) Anti CgA (Chromogranin A) mouse monoclonal antibody (clone DAK-A3), diluted 1:50 Dako A/S, Glostrup Denmark ...
