Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder.
Durham, United States. In Psychiatry Res, Oct 2015
The present study examined the association between genetic variation in the nicotinic receptor gene family (CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNA9, CHRNA10, CHRNB2, CHRNB3, CHRNB4) and the occurrence of posttraumatic stress disorder (PTSD).
New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder.
Barcelona, Spain. In Am J Med Genet B Neuropsychiatr Genet, Aug 2015
We detected other genes suggested to be involved in synaptic plasticity, cognitive function, neurological and neuropsychiatric disorders, and smoking behavior such as NUAK1, FGF20, NETO1, BTBD9, DLG2, TOP3B, and CHRNB4.
[A genetic view of addiction].
Paris, France. In Med Sci (paris), Apr 2015
This approach allowed the identification of the first susceptibility gene in addiction (tobacco), with genes CHRNA5, CHRNA3 and CHRNB4 encoding the α5, α3 and b4 subunits involved in the formation of nicotinic receptors, explaining 14% of the attributable risk for tobacco dependence.
Molecular mechanisms underlying behaviors related to nicotine addiction.
New Haven, United States. In Cold Spring Harb Perspect Med, 2013
Indeed, genetic variation in the CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the α5, α3, and β4 nAChR subunits, respectively, has been shown to increase vulnerability to tobacco dependence and smoking-associated diseases including lung cancer.