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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cholinergic receptor, nicotinic, beta 4

CHRNB4
may act as a subunit of a neuronal nicotinic acetylcholine receptor [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CHRNA3, AGE, HAD, CAN, CHRNB3
Papers on CHRNB4
Focused Analysis of Exome Sequencing Data for Rare Germline Mutations in Familial and Sporadic Lung Cancer.
New
Spitz et al., Houston, United States. In J Thorac Oncol, Jan 2016
iron-responsive element binding protein neuronal 2 (IREB2); cholinergic receptor, nicotinic, alpha 5 (neuronal) (CHRNA5); and cholinergic receptor, nicotinic, beta 4 (CHRNB4).
Gene variance in the nicotinic receptor cluster (CHRNA5-CHRNA3-CHRNB4) predicts death from cardiopulmonary disease and cancer in smokers.
New
Melander et al., Malmö, Sweden. In J Intern Med, Jan 2016
BACKGROUND: Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), peripheral artery disease and lung cancer.
A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence.
New
Johnson et al., New York City, United States. In Hum Mol Genet, Nov 2015
We tested for cis-methylation quantitative trait loci (cis-meQTLs) using SNP genotypes and DNA methylation levels measured across the IREB2-HYKK-PSMA4-CHRNA5-CHRNA3-CHRNB4 genes on chromosome 15q25.1 in the BrainCloud and Brain QTL cohorts [total N = 175 European-Americans and 65 African-Americans (AAs)].
Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder.
New
Beckham et al., Durham, United States. In Psychiatry Res, Oct 2015
The present study examined the association between genetic variation in the nicotinic receptor gene family (CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNA9, CHRNA10, CHRNB2, CHRNB3, CHRNB4) and the occurrence of posttraumatic stress disorder (PTSD).
Common single nucleotide variants underlying drug addiction: more than a decade of research.
Review
New
López-Moreno et al., Málaga, Spain. In Addict Biol, Sep 2015
SNPs in the alcohol metabolizing genes, in the cholinergic gene cluster CHRNA5-CHRNA3-CHRNB4, and in the DRD2 and ANNK1 genes, are, to date, the most replicated and significant gene variants associated with alcohol- and nicotine-related phenotypes.
Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses.
New
van den Oord et al., Richmond, United States. In Nicotine Tob Res, Sep 2015
INTRODUCTION: Genome-wide association study meta-analyses have robustly implicated three loci that affect susceptibility for smoking: CHRNA5\CHRNA3\CHRNB4, CHRNB3\CHRNA6 and EGLN2\CYP2A6.
New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder.
New
Sunyer et al., Barcelona, Spain. In Am J Med Genet B Neuropsychiatr Genet, Aug 2015
We detected other genes suggested to be involved in synaptic plasticity, cognitive function, neurological and neuropsychiatric disorders, and smoking behavior such as NUAK1, FGF20, NETO1, BTBD9, DLG2, TOP3B, and CHRNB4.
[A genetic view of addiction].
Review
New
Gorwood et al., Paris, France. In Med Sci (paris), Apr 2015
This approach allowed the identification of the first susceptibility gene in addiction (tobacco), with genes CHRNA5, CHRNA3 and CHRNB4 encoding the α5, α3 and b4 subunits involved in the formation of nicotinic receptors, explaining 14% of the attributable risk for tobacco dependence.
Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium.
Sattar et al., Trondheim, Norway. In Bmj Open, 2014
DESIGN: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes.
Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability.
Review
Kenny et al., Jupiter, United States. In Neuropharmacology, 2014
Second, genetic variation that modifies noxious responses to nicotine and thereby influences vulnerability to tobacco dependence, in particular variation in the CHRNA5-CHRNA3-CHRNB4 nicotinic acetylcholine receptor (nAChR) subunit gene cluster, will be discussed.
Molecular mechanisms underlying behaviors related to nicotine addiction.
Review
Kenny et al., New Haven, United States. In Cold Spring Harb Perspect Med, 2013
Indeed, genetic variation in the CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the α5, α3, and β4 nAChR subunits, respectively, has been shown to increase vulnerability to tobacco dependence and smoking-associated diseases including lung cancer.
The CHRNA5/A3/B4 gene cluster and tobacco, alcohol, cannabis, inhalants and other substance use initiation: replication and new findings using mixture analyses.
GeneRIF
Ehringer et al., United States. In Behav Genet, 2012
study provides evidence for a general role of the CHRNA5/A3/B4 gene cluster in substance use initiation that is not limited to nicotine and alcohol.
Carboetomidate inhibits alpha4/beta2 neuronal nicotinic acetylcholine receptors at concentrations affecting animals.
GeneRIF
Forman et al., Boston, United States. In Anesth Analg, 2012
Compared with etomidate, carboetomidate's higher hydrophobicity is associated with greater inhibition of alpha4/beta2 neuronal nicotinic acetylcholine receptors.
Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice.
GeneRIF
Dierssen et al., Barcelona, Spain. In Alcohol, 2012
transgenic mice with human alpha 5, alpha 3, beta 4 subunit genes drank less ethanol than wild-type in a two-bottle (ethanol vs. water) preference test; results suggest a complex role for this receptor subunit gene cluster in the modulation of ethanol's as well as nicotine's effects
Nicotinic acetylcholine receptor α7 and β4 subunits contribute nicotine-induced apoptosis in periodontal ligament stem cells.
GeneRIF
Heo et al., Seoul, South Korea. In Mol Cells, 2012
Collectively, the presence of alpha7 and beta4 nAChRs in PDLSCs supports a key role of Nicotinic acetylcholine receptor (nAChRs) in the modulation of nicotine-induced apoptosis
Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking.
GeneRIF
Goate et al., Saint Louis, United States. In Plos One, 2011
Quantitative trait disequilibrium test (QTDT) significant association was detected between age at onset of daily smoking and variants located upstream of CHRNB4.
Recent advances in understanding nicotinic receptor signaling mechanisms that regulate drug self-administration behavior.
Review
Kenny et al., Jupiter, United States. In Biochem Pharmacol, 2011
Consistent with this possibility, human genome-wide association studies have shown that genetic variation in the CHRNA5-CHRNA3-CHRNB4 gene cluster located in chromosome region 15q25, which encode the α5, α3 and β4 nAChR subunits, respectively, increases vulnerability to tobacco addiction and smoking-related diseases.
Nicotinic acetylcholine receptor polymorphism, smoking behavior, and tobacco-related cancer and lung and cardiovascular diseases: a cohort study.
Impact
GeneRIF
Nordestgaard et al., Copenhagen, Denmark. In J Clin Oncol, 2011
Nicotinic acetylcholine receptor polymorphisms are associated with additional increased risk of lung cancer, bladder cancer, and chronic obstructive pulmonary disease after adjustment for smoking.
Meta-analysis and imputation refines the association of 15q25 with smoking quantity.
Impact
Marchini et al., Oxford, United Kingdom. In Nat Genet, 2010
Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits.
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.
Impact
Brennan et al., Lyon, France. In Nature, 2008
The association region contains several genes, including three that encode nicotinic acetylcholine receptor subunits (CHRNA5, CHRNA3 and CHRNB4).
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