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Cholinergic receptor, nicotinic, alpha 9

This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: CHRNA7, CHRNB4, HAIR, CHRNB2, CHRNA3
Papers on CHRNA9
Atracurium Besylate and other neuromuscular blocking agents promote astroglial differentiation and deplete glioblastoma stem cells.
Bar et al., Cleveland, United States. In Oncotarget, Dec 2015
To investigate the clinical importance of nAChRs in gliomas, we examined clinical outcomes and found that glioma patients with tumors overexpressing CHRNA1 or CHRNA9 (encoding for the AChR-α1 or AChR-α9) exhibit significant shorter overall survival.
The contribution of rare and common variants in 30 genes to risk nicotine dependence.
Li et al., Charlottesville, United States. In Mol Psychiatry, Nov 2015
Rare variants in NRXN1, CHRNA9, CHRNA2, NTRK2, GABBR2, GRIN3A, DNM1, NRXN2, NRXN3 and ARRB2 were significantly associated with smoking status in the MSTCC AA sample, with weighted sum statistic (WSS) P-values ranging from 2.42 × 10(-3) to 1.31 × 10(-4) after 10(6) phenotype rearrangements.
Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder.
Beckham et al., Durham, United States. In Psychiatry Res, Oct 2015
The present study examined the association between genetic variation in the nicotinic receptor gene family (CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNA9, CHRNA10, CHRNB2, CHRNB3, CHRNB4) and the occurrence of posttraumatic stress disorder (PTSD).
CHRNA9 polymorphisms and smoking exposure synergize to increase the risk of breast cancer in Taiwan.
Chiou et al., Taipei, Taiwan. In Carcinogenesis, 2014
However, no studies have explored the joint effect of α9-nAChRs (CHRNA9) genes and cigarette smoking exposure on breast cancer risk.
Neuronal acetylcholine receptor subunit alpha-9 (CHRNA9) polymorphisms are associated with NSCLC risk in a Chinese population.
Bao et al., Hangzhou, China. In Med Oncol, 2014
Neuronal acetylcholine receptor subunit alpha-9 (CHRNA9) encodes a plasma membrane protein of divalent cation channels and is expressed in keratinocytes.
Expression of acetylcholine receptors by experimental rat renal allografts.
Grau et al., Gießen, Germany. In Biomed Res Int, 2013
In contrast, CHRNA9, CHRM4, and CHRM5 mRNA remained below the threshold of detection.
A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility.
Spanish Scleroderma Group et al., In Arthritis Res Ther, 2013
Two SNPs, PPARG rs310746 and CHRNA9 rs6832151, were selected for genotyping in the replication cohort (1,068 SSc patients and 6,762 healthy controls) based on the results of the first step.
New associations of the genetic polymorphisms in nicotinic receptor genes with the risk of lung cancer.
Grando et al., Irvine, United States. In Life Sci, 2012
In this study, we perform case-control analysis of CHRNA9 and CHRNA3 genes using 340 non-small cell lung cancer cases and 435 controls.
Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA.
McIntosh et al., Salt Lake City, United States. In J Neurochem, 2012
A two order of magnitude species difference in potency of alpha-conotoxin RgIA is reported for rat versus human alpha9alpha10 nAChR.
Phylogenetic differences in calcium permeability of the auditory hair cell cholinergic nicotinic receptor.
Elgoyhen et al., Buenos Aires, Argentina. In Proc Natl Acad Sci U S A, 2012
The properties of rat and chicken recombinant and native alpha9alpha10 receptors, were compared.
Spatial and temporal expression patterns of nicotinic acetylcholine α9 and α10 subunits in the embryonic and early postnatal inner ear.
Morley et al., Los Angeles, United States. In Neuroscience, 2011
mRNA expression of the nicotinic acetylcholine alpha9 receptor subunit precedes expression of the alpha10 subunit in both cochlear and vestibular hair cells.
A genome-wide association study identifies two new risk loci for Graves' disease.
China Consortium for Genetics of Autoimmune Thyroid Disease et al., Shanghai, China. In Nat Genet, 2011
These newly associated SNPs were correlated with the expression levels of RNASET2 at 6q27, of CHRNA9 and of a previously uncharacterized gene at 4p14, respectively.
Associations of nicotine intake measures with CHRN genes in Finnish smokers.
Kaprio et al., Helsinki, Finland. In Nicotine Tob Res, 2011
We first studied SNPs residing on selected nAChR subunit genes (CHRNA2, CHRNA4, CHRNA6/CHRNB3, CHRNA7, CHRNA9, CHRNA10, CHRNB2, CHRNG/CHRND) genotyped within a genome-wide association study for single SNP and multiple SNP associations by ordinal regression.
Tea polyphenol (-)-epigallocatechin-3-gallate inhibits nicotine- and estrogen-induced α9-nicotinic acetylcholine receptor upregulation in human breast cancer cells.
Ho et al., Taipei, Taiwan. In Mol Nutr Food Res, 2011
Significant increases in the alpha9-nAChR mRNA and protein levels in MCF-7 cells were detected 6 h after nicotine treatment. Nicotine- and estrogen-induced alpha9-nicotinic acetylcholine receptor upregulation was blocked by (-)-epigallocatechin-3-gallate.
Naturally occurring variants of human Α9 nicotinic receptor differentially affect bronchial cell proliferation and transformation.
Grando et al., Irvine, United States. In Plos One, 2010
Data suggest that the biologic activities of Alpha9 nicotinic receptor (CHRNA9) may be regulated at the splicing level, and genetic polymorphisms in CHRNA9 affecting protein levels, amino acid sequence and RNA splicing may influence the risk for lung cancer.
Constitutive expression of the alpha10 nicotinic acetylcholine receptor subunit fails to maintain cholinergic responses in inner hair cells after the onset of hearing.
Elgoyhen et al., Buenos Aires, Argentina. In J Assoc Res Otolaryngol, 2009
The retraction of these fibers after the onset of hearing correlates with the cessation of transcription of the Chrna10 (but not the Chrna9) gene in IHCs.
A point mutation in the hair cell nicotinic cholinergic receptor prolongs cochlear inhibition and enhances noise protection.
Elgoyhen et al., Buenos Aires, Argentina. In Plos Biol, 2009
Relative to their wild-type littermates, Chrna9(L9'T/L9'T) mice showed less permanent hearing loss following exposure to intense noise. Thus, a point mutation designed to alter alpha9alpha10 receptor gating has provided an animal model.
Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function.
Lerer et al., Jerusalem, Israel. In Genes Brain Behav, 2008
Response inhibition (MFFT, Stroop, CPT Loading Phase, TOL) was associated with variants in CHRNA2, CHRNA4, CHRNA5, CHRNA7, CHRNA9, CHRNA10, CHRNB2 and CHRNB3.
Transgenic and gene targeting studies of hair cell function in mouse inner ear.
Zuo, Memphis, United States. In J Neurobiol, 2002
Targeted inactivation using embryonic stem cell technology and transgenic expression studies have revealed the roles of several genes involved in hair cell lineage (Math1), differentiation (Pou4f3), mechanotransduction (Myo1c, and Myo7a), electromotility (Prestin), and efferent modulation (Chrna9, encoding alpha9 AChR).
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