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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cholinergic receptor, nicotinic, alpha 7

CHRNA7, alpha7 neuronal nicotinic acetylcholine receptor
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: alpha7, HAD, CAN, AGE, CHRNB2
Papers on CHRNA7
CHRNA7 inhibits cell invasion and metastasis of LoVo human colorectal cancer cells through PI3K/Akt signaling.
Chen et al., Hangzhou, China. In Oncol Rep, Feb 2016
The α7 neuronal nicotinic receptor gene (CHRNA7) is widely expressed in both the brain and periphery whereas its encoding protein of α7 neuronal acetylcholine receptor (α7nAChR) belongs to the nicotinic acetylcholine receptor family.
The 15q13.3 deletion syndrome: Deficient α(7)-containing nicotinic acetylcholine receptor-mediated neurotransmission in the pathogenesis of neurodevelopmental disorders.
Urbano et al., Norfolk, United States. In Prog Neuropsychopharmacol Biol Psychiatry, Feb 2016
Array comparative genomic hybridization (array CGH) has led to the identification of microdeletions of the proximal region of chromosome 15q between breakpoints (BP) 3 or BP4 and BP5 encompassing CHRNA7, the gene encoding the α7-nicotinic acetylcholine receptor (α7nAChR) subunit.
Perinatal Phosphatidylcholine Supplementation and Early Childhood Behavior Problems: Evidence for CHRNA7 Moderation.
Freedman et al., Denver, United States. In Am J Psychiatry, Jan 2016
The children's behavior is moderated by CHRNA7 variants associated with later mental illness and is related to their enhanced cerebral inhibition as newborns.
Association Study of CHRNA7 Promoter Variants with Sensory and Sensorimotor Gating in Schizophrenia Patients and Healthy Controls: A Danish Case-Control Study.
Glenthøj et al., Glostrup, Denmark. In Neuromolecular Med, Dec 2015
The CHRNA7 gene, encoding the subunit of the human α7 nicotinic acetylcholine receptor (α7nAChR), is suggested as a susceptibility factor for schizophrenia.
Effect of GTS-21, An Alpha7 Nicotinic Acetylcholine Receptor Agonist, on Clp-Induced Inflammatory, Gastrointestinal Motility and Colonic Permeability Changes in Mice.
De Winter et al., Leuven, Belgium. In Shock, Dec 2015
In this respect, selective alpha7 nicotinic acetylcholine receptor (α7nAChR) agonists have shown anti-inflammatory properties in several animal models of inflammation.
Expression of CHRFAM7A and CHRNA7 in neuronal cells and postmortem brain of HIV-infected patients: considerations for HIV-associated neurocognitive disorder.
Lasalde-Dominicci et al., San Juan, Puerto Rico. In J Neurovirol, Dec 2015
Hence, we studied both CHRNA7 and CHRFAM7A regulation patterns in various gp120IIIB in vitro conditions.
Evaluation of multiple putative risk alleles within the 15q13.3 region for genetic generalized epilepsy.
Berkovic et al., Melbourne, Australia. In Epilepsy Res, Nov 2015
Deficiency of the acetylcholine receptor gene CHRNA7 and the partial duplication, CHRFAM7A, may contribute to these phenotypes and we sought to comprehensively analyze these genes in genetic generalized epilepsy.
The human clinical phenotypes of altered CHRNA7 copy number.
Schaaf et al., Houston, United States. In Biochem Pharmacol, Nov 2015
Dosage sensitivity of the CHRNA7 gene, which encodes for the α7 nicotinic acetylcholine receptor in the human brain, has been proposed to have a major contribution to the observed cognitive and behavioral phenotypes, as it represents the smallest region of overlap to all the 15q13.3
Effect of Genetic Polymorphisms (SNPs) in CHRNA7 Gene on Response to Acetylcholinesterase Inhibitors (AChEI) in Patients with Alzheimer's Disease.
Fini et al., Roma, Italy. In Curr Drug Targets, Nov 2015
Acetylcholinesterase inhibitors (AChEI) are moderately active in AD. 7nAChR (nicotinic acetylcholine receptor), encoded by CHRNA7, is involved in cholinergic neurotransmission and AD pathogenesis.
The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function.
Leonard et al., Aurora, United States. In Neuropharmacology, Sep 2015
The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is ubiquitously expressed in both the central nervous system and in the periphery.
Natural genetic variability of the neuronal nicotinic acetylcholine receptor subunit genes in mice: Consequences and confounds.
Stitzel et al., United States. In Neuropharmacology, Sep 2015
Most studies on mouse nAChR subunit gene variability to date have focused on Chrna4, the gene that encodes the α4 nAChR subunit and Chrna7, the gene that encodes the α7 nAChR subunit.
Non-Neuronal Acetylcholine: The Missing Link Between Sepsis, Cancer, and Delirium?
Osorio et al., United States. In Front Med (lausanne), 2014
We hypothesize that age-induced ACh deficiency is the result of an epigenomic dysfunction of microRNA-6775 (miR-6775), which silences the transcription of CHRNA7 gene [coding for alpha 7 nicotinic cholinergic receptors (nAChRs)].
Structural characterization of binding mode of smoking cessation drugs to nicotinic acetylcholine receptors through study of ligand complexes with acetylcholine-binding protein.
Sixma et al., Amsterdam, Netherlands. In J Biol Chem, 2012
Data indicate that cytisine, varenicline, and nicotine are all high affinity binders for the alpha4beta2 nAChRs, but all display lower affinity for the alpha7 subtype receptor.
Potential state-selective hydrogen bond formation can modulate activation and desensitization of the α7 nicotinic acetylcholine receptor.
Horenstein et al., Gainesville, United States. In J Biol Chem, 2012
Potential state-selective hydrogen bond formation can modulate activation and desensitization of the alpha7 nicotinic acetylcholine receptor
Sperm epidermal growth factor receptor (EGFR) mediates α7 acetylcholine receptor (AChR) activation to promote fertilization.
Breitbart et al., Ramat Gan, Israel. In J Biol Chem, 2012
activation of alpha7 by ZP leads to SFK-dependent EGFR activation, Ca(2+) influx, and the acrosome reaction
Prolonged disynaptic inhibition in the cortex mediated by slow, non-α7 nicotinic excitation of a specific subset of cortical interneurons.
Hestrin et al., Tucson, United States. In J Neurosci, 2012
Cholinergic axons from the basal forebrain of transgenic mice excite a specific subset of cortical interneurons via a remarkably slow, non-alpha7 nicotinic receptor-mediated conductance.
Nicotinic acetylcholine receptor expression and susceptibility to cholinergic immunomodulation in human monocytes of smoking individuals.
de Jonge et al., Amsterdam, Netherlands. In Neuroimmunomodulation, 2011
Authors conclude that CHRNA7 expression on blood monocytes is upregulated in smoking individuals, which may contribute to cholinergic immunomodulation.
A small recurrent deletion within 15q13.3 is associated with a range of neurodevelopmental phenotypes.
Stankiewicz et al., Houston, United States. In Nat Genet, 2009
Although this deletion also affects OTUD7A, accumulated data suggest that haploinsufficiency of CHRNA7 is causative for the majority of neurodevelopmental phenotypes in the 15q13.3
15q13.3 microdeletions increase risk of idiopathic generalized epilepsy.
Sander et al., Kiel, Germany. In Nat Genet, 2009
microdeletions encompassing the CHRNA7 gene in 12 of 1,223 individuals with idiopathic generalized epilepsy (IGE), which were not detected in 3,699 controls (joint P = 5.32 x 10(-8)).
A recurrent 15q13.3 microdeletion syndrome associated with mental retardation and seizures.
Eichler et al., Seattle, United States. In Nat Genet, 2008
This recurrent 1.5-Mb deletion contains six genes, including a candidate gene for epilepsy (CHRNA7) that is probably responsible for the observed seizure phenotype.
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