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Cholinergic receptor, nicotinic, alpha 3

CHRNA3, V alpha 3
This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: CHRNB4, AGE, HAD, CAN, iMpact
Papers on CHRNA3
CHRNA5/CHRNA3 Locus Associates with Increased Mortality among Smokers.
New
Laitinen et al., Turku, Finland. In Copd, Feb 2016
UNASSIGNED: Polymorphisms in the nicotinic acetylcholine receptor gene (CHRNA5/CHRNA3 locus) have been associated with several smoking related traits such as nicotine dependence, cigarette consumption, smoking cessation, lung cancer, and COPD.
Gene variance in the nicotinic receptor cluster (CHRNA5-CHRNA3-CHRNB4) predicts death from cardiopulmonary disease and cancer in smokers.
New
Melander et al., Malmö, Sweden. In J Intern Med, Jan 2016
BACKGROUND: Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), peripheral artery disease and lung cancer.
Differential expression of minimal residual disease markers in peripheral blood and bone marrow samples from high-risk neuroblastoma patients.
New
Nishimura et al., Kōbe, Japan. In Oncol Lett, Nov 2015
In the present study, the expression of 11 previously validated MRD markers (CHRNA3, CRMP1, DBH, DCX, DDC, GABRB3, GAP43, ISL1, KIF1A, PHOX2B and TH) was determined in 23 pairs of PB and BM samples collected from seven high-risk neuroblastoma patients at the same time point, and the sample was scored as MRD-positive if one of the MRD markers exceeded the normal range.
Common single nucleotide variants underlying drug addiction: more than a decade of research.
Review
New
López-Moreno et al., Málaga, Spain. In Addict Biol, Sep 2015
SNPs in the alcohol metabolizing genes, in the cholinergic gene cluster CHRNA5-CHRNA3-CHRNB4, and in the DRD2 and ANNK1 genes, are, to date, the most replicated and significant gene variants associated with alcohol- and nicotine-related phenotypes.
Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses.
New
van den Oord et al., Richmond, United States. In Nicotine Tob Res, Sep 2015
INTRODUCTION: Genome-wide association study meta-analyses have robustly implicated three loci that affect susceptibility for smoking: CHRNA5\CHRNA3\CHRNB4, CHRNB3\CHRNA6 and EGLN2\CYP2A6.
[A genetic view of addiction].
Review
New
Gorwood et al., Paris, France. In Med Sci (paris), Apr 2015
This approach allowed the identification of the first susceptibility gene in addiction (tobacco), with genes CHRNA5, CHRNA3 and CHRNB4 encoding the α5, α3 and b4 subunits involved in the formation of nicotinic receptors, explaining 14% of the attributable risk for tobacco dependence.
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
COPDGene Investigators et al., Aurora, United States. In Bmc Genet, 2014
RESULTS: Among NHW in the COPDGene cohort, both measures of pulmonary function were significantly associated with SNPs at the 15q25 locus [containing CHRNA3/5, AGPHD1, IREB2, CHRNB4] (lowest p-value = 2.17 × 10(-11)), and FEV1/FVC was associated with a genomic region on chromosome 4 [upstream of HHIP] (lowest p-value = 5.94 × 10(-10)); both regions have been previously associated with COPD.
Candidate genes for COPD: current evidence and research.
Review
Lee et al., Ch'unch'ŏn, South Korea. In Int J Chron Obstruct Pulmon Dis, 2014
Recently, candidate genes for COPD identified by GWASs include CHRNA3/5 (cholinergic nicotine receptor alpha 3/5), IREB2 (iron regulatory binding protein 2), HHIP (hedgehog-interacting protein), FAM13A (family with sequence similarity 13, member A), and AGER (advanced glycosylation end product-specific receptor).
Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability.
Review
Kenny et al., Jupiter, United States. In Neuropharmacology, 2014
Second, genetic variation that modifies noxious responses to nicotine and thereby influences vulnerability to tobacco dependence, in particular variation in the CHRNA5-CHRNA3-CHRNB4 nicotinic acetylcholine receptor (nAChR) subunit gene cluster, will be discussed.
Genetic susceptibility to lung cancer and co-morbidities.
Review
Fong et al., Brisbane, Australia. In J Thorac Dis, 2013
Large scale, multi-cohort GWAS of mainly Caucasian, smoking, populations have identified strong associations for lung cancer mapped to chromosomal regions 15q [nicotinic acetylcholine receptor (nAChR) subunits: CHRNA3, CHRNA5], 5p (TERT-CLPTM1L locus) and 6p (BAT3-MSH5).
The CHRNA5/A3/B4 gene cluster and tobacco, alcohol, cannabis, inhalants and other substance use initiation: replication and new findings using mixture analyses.
GeneRIF
Ehringer et al., United States. In Behav Genet, 2012
study provides evidence for a general role of the CHRNA5/A3/B4 gene cluster in substance use initiation that is not limited to nicotine and alcohol.
Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice.
GeneRIF
Dierssen et al., Barcelona, Spain. In Alcohol, 2012
transgenic mice with human alpha 5, alpha 3, beta 4 subunit genes drank less ethanol than wild-type in a two-bottle (ethanol vs. water) preference test; results suggest a complex role for this receptor subunit gene cluster in the modulation of ethanol's as well as nicotine's effects
A functional polymorphism on chromosome 15q25 associated with survival of early stage non-small-cell lung cancer.
GeneRIF
Park et al., China. In J Thorac Oncol, 2012
CHRNA3 polymorphism on chromosome 15q25 is associated with early stage non-small-cell lung cancer.
Nicotinic receptor-mediated filtering of mitral cell responses to olfactory nerve inputs involves the α3β4 subtype.
GeneRIF
Vijayaraghavan et al., Aurora, United States. In J Neurosci, 2012
A mechanistic model provides sharpening of mitral cell receptive fields by activation of the alpha3beta4 subtype of nicotinic receptor, which could aid in odor discrimination and perceptual learning.
Strong association between two polymorphisms on 15q25.1 and lung cancer risk: a meta-analysis.
GeneRIF
Niu et al., Beijing, China. In Plos One, 2011
CHRNA3 gene rs1051730-A allele might be a risk-conferring factor for the development of lung cancer in Caucasians, but not in East-Asians.
Nicotinic acetylcholine receptor polymorphism, smoking behavior, and tobacco-related cancer and lung and cardiovascular diseases: a cohort study.
Impact
GeneRIF
Nordestgaard et al., Copenhagen, Denmark. In J Clin Oncol, 2011
Nicotinic acetylcholine receptor polymorphisms are associated with additional increased risk of lung cancer, bladder cancer, and chronic obstructive pulmonary disease after adjustment for smoking.
Meta-analysis and imputation refines the association of 15q25 with smoking quantity.
Impact
Marchini et al., Oxford, United Kingdom. In Nat Genet, 2010
Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits.
Genome-wide meta-analyses identify multiple loci associated with smoking behavior.
Impact
Tobacco and Genetics Consortium, Chapel Hill, United States. In Nat Genet, 2010
The strongest association was a synonymous 15q25 SNP in the nicotinic receptor gene CHRNA3 (rs1051730[A], beta = 1.03, standard error (s.e.) = 0.053, P = 2.8 x 10(-73)).
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.
Impact
GeneRIF
Houlston et al., Houston, United States. In Nat Genet, 2008
CHRNA5 and CHRNA3 are promising candidate genes in the region of 15q25.1 for lung cancer.
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.
Impact
Brennan et al., Lyon, France. In Nature, 2008
The association region contains several genes, including three that encode nicotinic acetylcholine receptor subunits (CHRNA5, CHRNA3 and CHRNB4).
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