BMP signalling: agony and antagony in the family.
Dublin, Ireland. In Trends Cell Biol, May 2015
Antagonists such as Noggin, Chordin, Gremlin (Grem1), and twisted gastrulation-1 (Twsg1) have been shown to inhibit BMP action in a range of different cell types and developmental stage-specific contexts.
The Bone Morphogenetic Proteins and Their Antagonists.
London, United Kingdom. In Vitam Horm, 2014
One mechanism for enabling tight spatiotemporal control of their activities is through a number of antagonist proteins, including Noggin, Follistatin, Chordin, Twisted gastrulation (TSG), and the seven members of the Cerberus and Dan family.
Spemann's organizer and the self-regulation of embryonic fields.
Los Angeles, United States. In Mech Dev, 2009
Long-range communication between the dorsal and ventral sides is mediated by the action of growth factor antagonists - such as the BMP antagonist Chordin - that regulate the flow of BMPs within the embryonic morphogenetic field.
BMP-7 as antagonist of organ fibrosis.
Aachen, Germany. In Front Biosci, 2008
Moreover, member of the CCN family, Endoglin, Sclerostin, Sclerostin domain-containing proteins, Gremlin, Noggin, Chordin, and Kielin/Chordin-like protein influence the biological activity of both cytokines.
Scaling of the BMP activation gradient in Xenopus embryos.
Israel. In Nature, 2008
Here we present evidence that in Xenopus, the BMP activity gradient is defined by a 'shuttling-based' mechanism, whereby the BMP ligands are translocated ventrally through their association with the BMP inhibitor Chordin.