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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Chordin

Chordin, Chd, Chrd
This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Noggin, CAN, BMP4, NODAL, V1a
Papers on Chordin
The Gyc76C Receptor Guanylyl Cyclase and the Foraging cGMP-Dependent Kinase Regulate Extracellular Matrix Organization and BMP Signaling in the Developing Wing of Drosophila melanogaster.
New
Blair et al., Madison, United States. In Plos Genet, Oct 2015
The developing crossveins of the wing of Drosophila melanogaster are specified by long-range BMP signaling and are especially sensitive to loss of extracellular modulators of BMP signaling such as the Chordin homolog Short gastrulation (Sog).
Dorsoventral patterning by the Chordin-BMP pathway: a unified model from a pattern-formation perspective for Drosophila, vertebrates, sea urchins and Nematostella.
New
Meinhardt, Tübingen, Germany. In Dev Biol, Oct 2015
Conserved from Cnidarians to vertebrates, the dorsoventral (DV) axis is patterned by the Chordin-BMP pathway.
A semi-automated mass spectrometric immunoassay coupled to selected reaction monitoring (MSIA-SRM) reveals novel relationships between circulating PCSK9 and metabolic phenotypes in patient cohorts.
New
Coulombe et al., Montréal, Canada. In Methods, Jul 2015
Seven PCSK9 peptides were monitored in plasma samples: one in the prodomain prior to the autocleavage site at Q152, one in the catalytic domain prior to the furin cleavage site at R218, two in the catalytic domain following R218, one in the cysteine and histidine rich domain (CHRD) and the C-terminal peptide phosphorylated at S688 and unmodified.
Molecular mechanism of CHRDL1-mediated X-linked megalocornea in humans and in Xenopus model.
New
Villavicencio-Lorini et al., Berlin, Germany. In Hum Mol Genet, Jul 2015
Chordin-Like 1 (CHRDL1) mutations cause non-syndromic X-linked megalocornea (XMC) characterized by enlarged anterior eye segments.
BMP signalling: agony and antagony in the family.
Review
New
Martin et al., Dublin, Ireland. In Trends Cell Biol, May 2015
Antagonists such as Noggin, Chordin, Gremlin (Grem1), and twisted gastrulation-1 (Twsg1) have been shown to inhibit BMP action in a range of different cell types and developmental stage-specific contexts.
The Bone Morphogenetic Proteins and Their Antagonists.
Review
Rider et al., London, United Kingdom. In Vitam Horm, 2014
One mechanism for enabling tight spatiotemporal control of their activities is through a number of antagonist proteins, including Noggin, Follistatin, Chordin, Twisted gastrulation (TSG), and the seven members of the Cerberus and Dan family.
Scaling of dorsal-ventral patterning by embryo size-dependent degradation of Spemann's organizer signals.
Impact
Sasai et al., Kōbe, Japan. In Cell, 2013
Spemann's organizer plays a key role in dorsal-ventral (DV) patterning in the amphibian embryo by secreting diffusible proteins such as Chordin, an antagonist to ventralizing bone morphogenetic proteins (BMPs).
BMP signaling balances proliferation and differentiation of muscle satellite cell descendants.
GeneRIF
Vortkamp et al., Essen, Germany. In Bmc Cell Biol, 2010
Chordin upregulated in primary satellite cell cultures and in regenerating muscles
Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos.
GeneRIF
De Robertis et al., Los Angeles, United States. In Dev Biol, 2010
The data indicate a role for CV2 and Chd in the establishment of the vertebral morphogenetic field through the long-range relocalization of Chd/BMP complexes.
Sox17 and chordin are required for formation of Kupffer's vesicle and left-right asymmetry determination in zebrafish.
GeneRIF
Dawid et al., Bethesda, United States. In Dev Dyn, 2010
Targeted knockdown of Sox17 and Chd in dorsal forerunner cells led to aberrant Left-Right (L-R) asymmetry establishment, as visualized by the expression of southpaw and lefty, and heart and pancreas placement in the embryo.
Secreted bone morphogenetic protein antagonists of the Chordin family.
Ohta et al., In Biomol Concepts, 2010
Chordin, Chordin-like 1, and Chordin-like 2 are secreted bone morphogenetic protein (BMP) antagonists with highly conserved Chordin-like cysteine-rich domains.
Zebrafish chordin-like and chordin are functionally redundant in regulating patterning of the dorsoventral axis.
GeneRIF
Greenspan et al., Madison, United States. In Dev Biol, 2010
Chl, like Chd, dorsalizes embryos upon overexpression and is cleaved by BMP1; loss-of-function experiments show Chl serves as a BMP antagonist with functions that overlap and are redundant with those of Chd in forming the dorsoventral axis.
Roles of bone morphogenetic protein signaling and its antagonism in holoprosencephaly.
Review
Anderson et al., Durham, United States. In Am J Med Genet C Semin Med Genet, 2010
Chordin and Noggin are endogenous, extracellular antagonists of BMP signaling that promote the normal organization of the forebrain and face.
Binding between Crossveinless-2 and Chordin von Willebrand factor type C domains promotes BMP signaling by blocking Chordin activity.
GeneRIF
Hammerschmidt et al., Köln, Germany. In Plos One, 2009
Binding of CV2 to Chordin promotes BMP-2 signaling.
Spemann's organizer and the self-regulation of embryonic fields.
Review
De Robertis, Los Angeles, United States. In Mech Dev, 2009
Long-range communication between the dorsal and ventral sides is mediated by the action of growth factor antagonists - such as the BMP antagonist Chordin - that regulate the flow of BMPs within the embryonic morphogenetic field.
Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction.
Impact
Sato et al., New York City, United States. In Nat Cell Biol, 2009
Recently however, Xenopus laevis and zebrafish sFRP, Sizzled, was shown to function as an antagonist of Chordin processing by Tolloid-like metalloproteinases.
BMP-7 as antagonist of organ fibrosis.
Review
Gressner et al., Aachen, Germany. In Front Biosci, 2008
Moreover, member of the CCN family, Endoglin, Sclerostin, Sclerostin domain-containing proteins, Gremlin, Noggin, Chordin, and Kielin/Chordin-like protein influence the biological activity of both cytokines.
Scaling of the BMP activation gradient in Xenopus embryos.
Impact
Barkai et al., Israel. In Nature, 2008
Here we present evidence that in Xenopus, the BMP activity gradient is defined by a 'shuttling-based' mechanism, whereby the BMP ligands are translocated ventrally through their association with the BMP inhibitor Chordin.
Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein.
Impact
Hibi et al., Kōbe, Japan. In Nat Cell Biol, 2006
We found that Sizzled stabilizes Chordin, a Bmp antagonist, by binding and inhibiting the Tolloid-family metalloproteinase, Bmp1a, which cleaves and inactivates Chordin.
Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases.
Impact
De Robertis et al., Los Angeles, United States. In Cell, 2006
Microinjection experiments suggest that the Frizzled domain of Sizzled regulates the activity of Xolloid-related (Xlr), a metalloproteinase that degrades Chordin, through the following molecular pathway: Szl -| Xlr -| Chd -| BMP --> P-Smad1 --> Szl.
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