Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS inductionmore suppliers
In Marine Drugs, 2011
... calreticulin(CALR), protein disulfide isomerase (PDI), Bax, Bcl-xL and Bcl-2, PERK, phospho-PERK (p-PERK), phospho-elF2α (p-elF2α) and CHOP were from Cell Signaling Technology (Danvers, MA, USA) ...
Traditional Chinese medicine targeting apoptotic mechanisms for esophageal cancer therapy.
Shijiazhuang, China. In Acta Pharmacol Sin, Jan 2016
By using different monomers and composite prescriptions of TCM, it is possible to modulate the ratio of Bcl-2/Bax, regulate the expression of caspase proteases and mitochondrial transmembrane potential, increase the expression of Fas and p53, down-regulate NF-κB pathway and the expression of CHOP and survivin, and block cell cycle progression.
Bortezomib-based therapy for newly diagnosed mantle-cell lymphoma.
Aş Şanamayn, Syria. In N Engl J Med, Apr 2015
We investigated whether substituting bortezomib for vincristine in frontline therapy with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) could improve outcomes in patients with newly diagnosed mantle-cell lymphoma.
Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review.
More papers using
Zürich, Switzerland. In Mol Cancer, 2014
More than half of DLBLC patients can be cured with standard R-CHOP regimens, however approximately 30 to 40 % of patients will develop relapsed/refractory disease that remains a major cause of morbidity and mortality due to the limited therapeutic options.Recent advances in gene expression profiling have led to the identification of at least three distinct molecular subtypes of DLBCL: a germinal center B cell-like subtype, an activated B cell-like subtype, and a primary mediastinal B-cell lymphoma subtype.
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
In Cell Death & Disease, 1994
... cleaved forms; 1:200, IMG-273, IMGENEX, San Diego, CA, USA), anti-Bip (1:500, #3177, Cell Signaling Technology), anti-CHOP (1:200, sc-575, Santa Cruz Biotechnology), anti- ...