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DNA-damage-inducible transcript 3

CHOP, GADD153
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010] (from NCBI)
Papers using CHOP antibodies
Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction
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Wu Yu-Jen et al., In Marine Drugs, 2011
... calreticulin(CALR), protein disulfide isomerase (PDI), Bax, Bcl-xL and Bcl-2, PERK, phospho-PERK (p-PERK), phospho-elF2α (p-elF2α) and CHOP were from Cell Signaling Technology (Danvers, MA, USA) ...
Thematic review series: glycerolipids. Mammalian glycerol-3-phosphate acyltransferases: new genes for an old activity
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Bar-Tana Jacob et al., In Diabetes, 2007
... Anti- STAT3, FoxO1, P-FoxO1(T24)/P-FoxO3a(T32), rabbit C/EBPβ/LAP, and CHOP antibodies were from Cell Signaling Technology ...
High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice.
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Ferreira Sergio T., In PLoS ONE, 2007
... siRNA to gadd153/CHOP and non silencing control siRNA were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Novel role of protein disulfide isomerase in the regulation of NADPH oxidase activity: pathophysiological implications in vascular diseases.
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Kowaltowski Alicia J., In PLoS ONE, 2007
... Antibodies were obtained as follows: PDI and KDEL from Assay Designs/Stressgen (Ann Arbor, MI); CHOP/GADD153 from Thermo Scientific (Golden, CO); Akt, phospho-Akt, ...
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells
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Rozenfeld R et al., In Cell Death & Disease, 2007
... , anti-phospho-PERK, mouse monoclonal anti-CHOP (Cell Signaling Technology, Danvers, MA, USA), ...
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Papers on CHOP
ERK1/2-dependent bestrophin-3 expression prevents ER-stress-induced cell death in renal epithelial cells by reducing CHOP.
GeneRIF
Thévenod et al., Witten, Germany. In Biochim Biophys Acta, 2012
ERK1/2-dependent Best-3 activation regulates cell fate decisions during endoplasmic reticulum stress by suppressing CHOP induction and death.
Lipocalin 2, a new GADD153 target gene, as an apoptosis inducer of endoplasmic reticulum stress in lung cancer cells.
GeneRIF
Ko et al., T'ai-chung-shih, Taiwan. In Toxicol Appl Pharmacol, 2012
lipocalin 2 is a new GADD153 target gene that mediates endoplasmic reticulum stress-induced apoptosis in lung cancer cells
Reactive oxygen species-triggered trophoblast apoptosis is initiated by endoplasmic reticulum stress via activation of caspase-12, CHOP, and the JNK pathway in Toxoplasma gondii infection in mice.
GeneRIF
Shen et al., Hefei, China. In Infect Immun, 2012
It was concluded that apoptosis in placental trophoblasts was initiated predominantly by ROS-mediated ERS via activation of caspase-12, CHOP, and the JNK pathway in acute T. gondii infection.
Endoplasmic reticulum stress in retinal vascular degeneration: protective role of resveratrol.
GeneRIF
Zheng et al., Wuhan, China. In Invest Ophthalmol Vis Sci, 2012
High dosage of resveratrol pretreatment inhibited the injury-induced up-regulation of eIF2alpha-CHOP and IRE1alpha-XBP1 pathways.
Free cysteine modulates the conformation of human C/EBP homologous protein.
GeneRIF
Jia et al., Kingston, Canada. In Plos One, 2011
These results suggested a potential regulatory function of L-cysteine which may lead to changes in global conformation of CHOP in response to the cellular redox state and/or endoplasmic reticulum stress.
More papers using CHOP antibodies
Neuronal conduction of excitation without action potentials based on ceramide production
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Hoheisel Jörg D., In PLoS ONE, 2006
... immunoglobulins (IgG), antibodies to PTEN, to (Ser380)phospho-PTEN, to GSK-3β, to (Ser9)phospho GSK-3β, and antibodies to CHOP were from Cell Signaling (Beverly, MA) ...
Mechanisms of glucose-induced secretion of pancreatic-derived factor (PANDER or FAM3B) in pancreatic beta-cells
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Sun Zilin et al., In International Journal of Molecular Sciences, 2004
... anti-GAPDH, phosphor-eIF2α, eIF2α, caspase 3 and insulin antibodies were purchased from Cell signaling technology, rabbit anti-CHOP (GADD153) antibody were from Santa Cruz Biotechnology.
Hepatitis C virus non-structural proteins in the probable membranous compartment function in viral genome replication.
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Jhaveri Ravi, In PLoS ONE, 2002
... (p-PERK), and CHOP were purchased from Cell Signaling Technology (Beverly, USA) ...
Protection of retinal epithelial cells against oxidative injury by endoplasmic reticulum stress preconditioning is mediated by ERK1/2 activation
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Wu Jang-Yen et al., In Journal of Biomedical Science, 2002
... Mouse anti-actin, rabbit anti-Bax, rabbit anti–Bcl-2, rabbit anti-GRP78, rabbit anti-CHOP/GADD153 antibodies, and secondary mouse and rabbit antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity
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Murakami Koji et al., In Journal of Lipid Research, 2001
... Antibodies against PERK, eIF2, phospho-eIF2, and CHOP were purchased from Cell Signaling Technology (Beverly, MA) ...
Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor
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Tabas Ira et al., In The Journal of Cell Biology, 1997
... The mouse monoclonal antibodies against GADD 153 (CHOP) and tubulin were purchased from Santa Cruz Biotechnology, Inc ...
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
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Ron David et al., In The Journal of Cell Biology, 1997
... CHOP coding region, to enhanced green fluorescent protein (GFP) (CLONTECH Laboratories, Inc.) and termination ...
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
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Pereira T S et al., In Cell Death & Disease, 1994
... cleaved forms; 1:200, IMG-273, IMGENEX, San Diego, CA, USA), anti-Bip (1:500, #3177, Cell Signaling Technology), anti-CHOP (1:200, sc-575, Santa Cruz Biotechnology), anti- ...
Castanospermine inhibits alpha-glucosidase activities and alters glycogen distribution in animals.
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Chammas Roger, In PLoS ONE, 1984
... western blotting, anti-KDEL for GRP78 and GRP94 was purchased from Stressgen, (Ann Arbor, MI), polyclonal anti-CHOP/GADD153 was purchased from Santa Cruz Biotechnology (Santa Cruz, CA), and ...
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