gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Galactosamine

chondroitinase
This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, hyaluronidase, V1a
Papers using chondroitinase antibodies
Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells
Supplier
Zachary Ian C. et al., In Biochemical Journal, 2009
... Chondroitinase ABC and heparinase III (heparitinase) were from Sigma, and the following antibodies were from Santa Cruz Biotechnology: anti-NRP1 (C-19), anti-NRP2 (C-9), ...
Growth factor–induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells
Supplier
Lander Arthur D. et al., In The Journal of Cell Biology, 1994
... Heparinase III and chondroitinase ABC were purchased from Seikagaku; GM6001 (Galardin) was obtained from BIOMOL Research Laboratories, Inc.; Texas ...
Papers on chondroitinase
Suppression of HIV-1 Infectivity by Human Glioma Cells.
New
Hoshino et al., Dhaka, Bangladesh. In Aids Res Hum Retroviruses, Feb 2016
This inhibitory effect was eliminated by the treatment of the SCM with chondroitinase ABC but not heparinase, suggesting that the inhibitory factor(s) secreted by NP-2 and U87MG cells was chiefly mediated by chondroitin sulfate (CS) or CS-like moiety.
Actin resistant DNAse I expression from oncolytic adenovirus Enadenotucirev enhances its intratumoural spread and reduces tumour growth.
New
Fisher et al., Oxford, United Kingdom. In Mol Ther, Jan 2016
Non-replicating Ad5 vectors expressing actin-resistant DNase (aDNAse I), proteinase K (PK), hyaluronidase (rhPH20) and chondroitinase ABC (CABC) were injected into established DLD human colorectal adenocarcinoma xenografts, transcomplemented with a replicating Ad5 virus.
Multi-parametric MRI characterization of enzymatically degraded articular cartilage.
New
Nieminen et al., Kuopio, Finland. In J Orthop Res, Jan 2016
Bovine osteochondral specimens were subjected to 44h incubation in control medium or in collagenase or chondroitinase ABC to induce superficial collagen or proteoglycan (glycosaminoglycan) alterations.
Mast Cells Produce a Unique Chondroitin Sulfate Epitope.
New
Lord et al., Sydney, Australia. In J Histochem Cytochem, Dec 2015
This study investigated a unique CS structure produced by mast cells that was detected with the antibody clone 2B6 in the absence of chondroitinase ABC digestion.
[TRANSPLANTATION OF NEURAL STEM CELLS INDUCED BY ALL-TRANS- RETINOIC ACID COMBINED WITH GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR AND CHONDROITINASE ABC FOR REPAIRING SPINAL CORD INJURY OF RATS].
New
Yu et al., In Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, Aug 2015
OBJECTIVE: To observe the effect of transplantation of neural stem cells (NSCs) induced by all-trans-retinoic acid (ATRA) combined with glial cell line derived neurotrophic factor (GDNF) and chondroitinase ABC (ChABC) on the neurological functional recovery of injured spinal cord in Sprague Dawley (SD) rats.
[Research progress in chondroitinase ABC].
Review
New
Yuan et al., In Sheng Wu Gong Cheng Xue Bao, May 2015
However, the appearance of chondroitinase ABC (ChSase ABC), which can lyse polysaccharides, solves the difficulties.
Multifunctional therapeutic delivery strategies for effective neuro-regeneration following traumatic spinal cord injury.
Review
Pillay et al., Johannesburg, South Africa. In Curr Pharm Des, 2014
This review provides a brief overview of multifunctional therapeutic delivery strategies for effective neuroregeneration post-TSCI with special emphasis on intrathecal hydrogel-based injectable systems, chondroitinase ABC releasing matrices, micro/nano-sized particulate strategies, 3D-scaffold architectures, biopolymeric channeled bridges for directed neuronal growth, functionalized nerve conduits, nano- and micro-fibrous scaffolds and multicomponent combinatorial paradigms for localized delivery to spinal cord.
The role of chondroitinase as an adjuvant to peripheral nerve repair.
Review
Marra et al., Pittsburgh, United States. In Cells Tissues Organs, 2013
The utilization of chondroitinase ABC (chABC) has led to a marked increase in the ability of injured axons to regenerate across gaps through the CSPG-laden extracellular matrix.
Targeting of ECM molecules and their metabolizing enzymes and receptors for the treatment of CNS diseases.
Review
Dityatev et al., Copenhagen, Denmark. In Prog Brain Res, 2013
ECM-targeting treatments include chondroitinase ABC, heparin/heparan sulfate-mimicking oligosaccharides, ECM cross-linking antibodies, and drugs stimulating expression of ECM molecules.
Cell therapy in spinal cord injury: a mini- reivew.
Review
Joghataei et al., Tehrān, Iran. In Basic Clin Neurosci, 2012
In later studies, was applied simultaneous transplantation of stem cells with chondroitinase ABC in SCI models with the aid of nanoparticles.
Mucopolysaccharidosis IVA within Tunisian patients: Confirmation of the two novel GALNS gene mutations.
GeneRIF
Laradi et al., Sousse, Tunisia. In Pathol Biol (paris), 2012
Screening of mutations and polymorphisms in GALNS gene provide useful information on genotype/phenotype correlations.
Functional regeneration of respiratory pathways after spinal cord injury.
Impact
Silver et al., Cleveland, United States. In Nature, 2011
Digestion of these potently inhibitory extracellular matrix molecules with chondroitinase ABC (denoted ChABC) could, by itself, promote the plasticity of tracts that were spared and restore limited activity to the paralysed diaphragm.
Polymorphisms in Tunisian patients with N-acetylgalactosamine-6-sulfate sulfatase gene deficiency: implication in Morquio A disease.
GeneRIF
Laradi et al., Sousse, Tunisia. In Diagn Pathol, 2010
Mucopolysaccharidosis type IVA or Morquio A syndrome is characterized by the lack of N-acetylgalactosamine-6-sulfate-sulfatase and the accumulation of keratan sulfate and chondroitin-6-sulfate in the lysosomes.
Mucopolysaccharidosis IVA mutations in Chinese patients: 16 novel mutations.
GeneRIF
Huang et al., Beijing, China. In J Hum Genet, 2010
GALNS mutations are associated with Mucopolysaccharidosis IVA.
Perineuronal nets protect fear memories from erasure.
Impact
Herry et al., Basel, Switzerland. In Science, 2009
In adults, degradation of PNNs by chondroitinase ABC specifically rendered subsequently acquired fear memories susceptible to erasure.
Deficiency in N-acetylgalactosamine-6-sulfate sulfatase results in collagen perturbations in cartilage of Morquio syndrome A patients.
GeneRIF
Everts et al., Groningen, Netherlands. In Mol Genet Metab, 2009
Deficiency in N-acetylgalactosamine-6-sulfate sulfatase has an impact on the phenotypic properties of chondrocytes, resulting in the formation of cartilage that is more prone to degeneration.
Descriptively quantitative relationship between mutated N-acetylgalactosamine-6-sulfatase and mucopolysaccharidosis IVA.
GeneRIF
Wu et al., Nanning, China. In Biopolymers, 2008
Results describe the quantitative relationship between the mutant N-acetylgalactosamine-6-sulfatase and the occurrence of mucopolysaccharidosis IVA.
Reactivation of ocular dominance plasticity in the adult visual cortex.
Impact
Maffei et al., Pisa, Italy. In Science, 2002
After CSPG degradation with chondroitinase-ABC in adult rats, monocular deprivation caused an ocular dominance shift toward the nondeprived eye.
Chondroitinase ABC promotes functional recovery after spinal cord injury.
Impact
McMahon et al., London, United Kingdom. In Nature, 2002
To test the functional effects of degrading chondroitin sulphate (CS)-GAG after spinal cord injury, we delivered chondroitinase ABC (ChABC) to the lesioned dorsal columns of adult rats.
Specific release of proteoglycans from human natural killer cells during target lysis.
Impact
Ritz et al., In Nature, 1985
In recent studies, human NK cell clones have been shown to contain a 200,000-Mr (relative molecular mass) protease-resistant chondroitin sulphate A proteoglycan, which has been localized to the secretory granule by X-ray dispersive analysis and by its resistance to cleavage by extracellular addition of chondroitinase AC or ABC (ref.
share on facebooktweetadd +1mail to friends