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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Choline kinase alpha

choline kinase, Proton-pump, CHK
kinase of the CDP-choline pathway [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, V1a, PI3K
Papers using choline kinase antibodies
Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets.
Supplier
Uversky Vladimir N., In PLoS ONE, 1996
... from BioSource, rabbit anti-Csk (C-20) and anti-Ctk from Santa Cruz, mouse-anti-Csk (clone 52) and mouse anti-CHK from BD BioSciences, mouse anti-Src (clone GD11) ...
Papers on choline kinase
Acute Coronary Syndromes, Gastrointestinal Protection, and Recommendations Regarding Concomitant Administration of Proton-Pump Inhibitors (Omeprazol/Esomeprazole) and Clopidogrel.
New
Gomez-Jaume et al., Gijón, Spain. In Am J Cardiol, Mar 2016
In conclusion, almost the totality of the patients with an ACS receive gastroprotective agents at the moment of discharge, most of them with proton-pump inhibitors.
Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery.
New
Dalgarno et al., Cambridge, United States. In J Med Chem, Feb 2016
UNASSIGNED: Choline kinase α (ChoKα) is an enzyme involved in the synthesis of phospholipids and thereby plays key roles in regulation of cell proliferation, oncogenic transformation, and human carcinogenesis.
Practical considerations in the management of proton-pump inhibitors.
New
Albillos Martínez et al., Spain. In Rev Esp Enferm Dig, Jan 2016
UNASSIGNED: Proton-pump inhibitors (PPIs) are one of the most active ingredients prescribed in Spain.
The Caenorhabditis elegans Werner syndrome protein participates in DNA damage checkpoint and DNA repair in response to CPT-induced double-strand breaks.
New
Ahn et al., Ulsan, South Korea. In Cell Signal, Jan 2016
We found that WRN-1 is involved in the checkpoint response to DSBs after CPT, inducing cell cycle arrest, is recruited to DSBs by RPA-1 and functions upstream of ATL-1 and ATM-1 for CHK-1 phosphorylation in the S-phase checkpoint.
Targeted therapies in bladder cancer: an overview of in vivo research.
Review
New
Zwarthoff et al., Rotterdam, Netherlands. In Nat Rev Urol, Dec 2015
Several other targets, for example COX-2, IL-12, Bcl-xL, livin and choline kinase α, have also been observed to inhibit tumour growth, but these findings have not been replicated to date.
Increased activity of CHK enhances the radioresistance of MCF-7 breast cancer stem cells.
New
Jiang et al., Suzhou, China. In Oncol Lett, Dec 2015
DNA damage may lead to activation of the checkpoint kinase (CHK) signaling pathway, of which debromohymenialdisine (DBH) is a specific inhibitor.
Magnesium Deficiency and Proton-Pump Inhibitor Use: A Clinical Review.
Review
New
Danziger et al., Boston, United States. In J Clin Pharmacol, Dec 2015
UNASSIGNED: The association of proton-pump inhibitor (PPI) use and hypomagnesemia has garnered much attention over the last five years.
'Lemonade Legs': Why do Some Patients Get Profound Hypomagnesaemia on Proton-Pump Inhibitors?
Review
New
Travis et al., Oxford, United Kingdom. In Intestinal Res, Jul 2015
Proton pump inhibitors (PPIs) are widely used though an association with hypomagnesaemia and hypocalcaemia has only been described since 2006.
Hypomagnesemia Induced by Long-Term Treatment with Proton-Pump Inhibitors.
Review
Milani et al., Bellinzona, Switzerland. In Gastroenterol Res Pract, 2014
In 2006, hypomagnesemia was first described as a complication of proton-pump inhibitors.
Risk of community-acquired pneumonia with outpatient proton-pump inhibitor therapy: a systematic review and meta-analysis.
Review
Crowell et al., Baltimore, United States. In Plos One, 2014
BACKGROUND: Proton-pump inhibitors (PPIs) are among the most frequently prescribed medications.
Circadian expression of H,K-ATPase type 2 contributes to the stability of plasma K⁺ levels.
GeneRIF
Crambert et al., Paris, France. In Faseb J, 2012
HKA2-null mice fed a normal diet have 2-fold higher K(+) renal excretion during rest. Under K(+) restriction, their urinary K(+) loss is 40% higher during the activity period.
Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase α inhibition.
GeneRIF
Lacal et al., Madrid, Spain. In Curr Cancer Drug Targets, 2012
ASAH1 inhibition synergistically sensitizes lung cancer cells resistant to the antiproliferative effect of choline kinase alpha inhibitors.
TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy.
GeneRIF
Mignot et al., Beijing, China. In Sleep Med, 2012
The study extends on the observation of a strong multiethnic association of polymorphisms in the TCRA and P2RY11 with narcolepsy, but does not confirm the association of CPT1B/CHKB (rs5770917) in the Chinese population.
Use of [11C]choline PET-CT as a noninvasive method for detecting pelvic lymph node status from prostate cancer and relationship with choline kinase expression.
GeneRIF
Mangar et al., London, United Kingdom. In Clin Cancer Res, 2012
Data show choline kinase alpha (CHKalpha) expressed in both cytoplasm and nucleus in malignant lesions.
Choline metabolism in malignant transformation.
Review
Impact
Ronen et al., Baltimore, United States. In Nat Rev Cancer, 2011
Furthermore, enzymes of choline metabolism, such as choline kinase, present novel targets for image-guided cancer therapy.
Expression of the non-gastric H+/K+ ATPase ATP12A in normal and pathological human prostate tissue.
GeneRIF
Ritter et al., Salzburg, Austria. In Cell Physiol Biochem, 2010
No significantly different expression levels could be detected in the various disease states compared to normal tissue.
Clopidogrel with or without omeprazole in coronary artery disease.
Impact
COGENT Investigators et al., Boston, United States. In N Engl J Med, 2010
Proton-pump inhibitors (PPIs) are believed to decrease the risk of such complications, though no randomized trial has proved this in patients receiving dual antiplatelet therapy.
Meiotic chromosome homology search involves modifications of the nuclear envelope protein Matefin/SUN-1.
Impact
Jantsch et al., Vienna, Austria. In Cell, 2009
These CHK-2 dependent phosphorylations occur in leptotene/zygotene, diminish during pachytene and are involved in pairing.
Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials.
Review
Impact
Wiviott et al., Boston, United States. In Lancet, 2009
BACKGROUND: Proton-pump inhibitors (PPIs) are often prescribed in combination with thienopyridines.
Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study.
Impact
Lacal et al., Madrid, Spain. In Lancet Oncol, 2007
The aim of this study was to assess whether choline kinase alpha (ChoKalpha) gene expression could identify patients with different prognoses.
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