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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Choline acetyltransferase

choline acetyltransferase, Choline O-Acetyltransferase, ChAT
Top mentioned proteins: acetylcholinesterase, CAN, HAD, V1a, ACID
Papers using choline acetyltransferase antibodies
Neural regulation of in vitro giant contractions in the rat colon
Li Qian Qian et al., In Journal of Molecular Neuroscience, 2000
... A rabbit anti-rat nitric oxide synthase I polyclonal antibody and a rabbit anti-ChAT polyclonal antibody were purchased from Beijing Biosynthesis Biotechnology Co., Ltd ...
Papers on choline acetyltransferase
p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism.
Svenningsson et al., Stockholm, Sweden. In Proc Natl Acad Sci U S A, Feb 2016
Selective deletion of p11 in cholinergic acetyltransferase (ChAT) neurons reduces tacrine-induced tremor.
Topographic organization of the basal forebrain projections to the perirhinal, postrhinal, and entorhinal cortex in rats.
Zaborszky et al., Newark, United States. In J Comp Neurol, Feb 2016
In this study, we examined the topographic organization of cholinergic and non-cholinergic projections from the BF to the perirhinal, postrhinal, and entorhinal cortex using retrograde tracing combined with ChAT (choline acetyltransferase) immunohistochemistry in rats.
Myocardial Infarction Causes Transient Cholinergic Transdifferentiation of Cardiac Sympathetic Nerves via gp130.
Habecker et al., Portland, United States. In J Neurosci, Feb 2016
Immunohistochemistry 14 d after MI revealed choline acetyltransferase (ChAT) in stellate sympathetic neurons and vesicular ACh transporter immunoreactivity in tyrosine hydroxylase-positive cardiac sympathetic fibers.
Dual projections of single orexin- or CART-immunoreactive, lateral hypothalamic neurons to the paraventricular thalamic nucleus and nucleus accumbens shell in the rat: Light microscopic study.
Lee et al., Seoul, South Korea. In Brain Res, Feb 2016
At the light microscopic level, ORX (or CART) terminals formed close appositions to choline acetyltransferase (ChAT)-, glutamate decarboxylase (GAD)-, or enkephalin (Enk)-immunoreactive neuronal elements in the AcbSh.
Brain cholinergic alterations in rats subjected to repeated immobilization or forced swim stress on lambda-cyhalothrin exposure.
Khanna et al., Lucknow, India. In Neurochem Int, Jan 2016
Decrease in acetylcholinesterase activity, protein expression of ChAT and PKC-β1 associated with decreased mRNA expression of CHRM2, AChE and ChAT in frontal cortex and hippocampus was also evident in rats pre-exposed to IMS or FSS on LCT treatment, compared to rats exposed to IMS or FSS or LCT alone.
From the 90׳s to now: A brief historical perspective on more than two decades of estrogen neuroprotection.
Simpkins et al., Morgantown, United States. In Brain Res, Jan 2016
Active avoidance behavior and choline acetyltransferase (ChAT) activity in the frontal cortex and hippocampus were assessed at 5 and 28 weeks postovariectomy while performance on the Morris water task and high-affinity choline uptake (HACU) were measured only at the 5-week time point.
A direct GABAergic output from the basal ganglia to frontal cortex.
Sabatini et al., Boston, United States. In Nature, Jun 2015
Two cell types make up the GP-FC projection, distinguished by their electrophysiological properties, cortical projections and expression of choline acetyltransferase (ChAT), a synthetic enzyme for the neurotransmitter acetylcholine (ACh).
The heart's 'little brain' controlling cardiac function in the rabbit.
Brack, Leicester, United Kingdom. In Exp Physiol, May 2015
Using immunohistochemistry, neurons were found to contain choline acetyltransferase or tyrosine hydroxylase and/or neuronal nitric oxide synthase in differing amounts (choline acetyltransferase > tyrosine hydroxylase > neuronal nitric oxide synthase).
Role of α7 nicotinic receptor in the immune system and intracellular signaling pathways.
Lewicki et al., Warsaw, Poland. In Cent Eur J Immunol, 2014
In humans, this versatile molecule and its synthesizing enzyme, choline acetyltransferase, have been found in various non-neural tissues such as the epithelium, endothelium, mesothelium muscle, blood cells and immune cells.
The Retinal TNAP.
Somogyvári et al., Budapest, Hungary. In Subcell Biochem, 2014
These strata exactly corresponded those seen after quadruple immunohistochemistry with four canonical IPL markers (tyrosine hydroxylase, choline acetyltransferase, calretinin, protein kinase C α). Diabetes results in diminishing retinal TNAP activity before changes in canonical markers could be observed in a rat model.
Beyond the Hypothesis of Serum Anticholinergic Activity in Alzheimer's Disease: Acetylcholine Neuronal Activity Modulates Brain-Derived Neurotrophic Factor Production and Inflammation in the Brain.
Hori et al., Tokyo, Japan. In Neurodegener Dis, 2014
We speculate that BDNF is related to some neurocognitive process and reflects neuronal activity in other neurodegenerative and neuropsychiatric disorders and that in the mild cognitive impairment stage, BDNF and choline acetyltransferase (ChAT) activities are hyperactivated because of a compensatory mechanism of AD pathology.
Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis.
Elmquist et al., Dallas, United States. In Cell Metab, 2011
Re-expression of MC4Rs in cholinergic neurons (ChAT-Cre, loxTB MC4R mice) modestly reduced body weight gain without altering food intake and was sufficient to normalize energy expenditure and attenuate hyperglycemia and hyperinsulinemia.
Function of neuromuscular synapses in the zebrafish choline-acetyltransferase mutant bajan.
Brehm et al., Stony Brook, United States. In J Neurophysiol, 2008
We have identified a zebrafish mutant line, bajan, in which compromised motility and fatigue result from a point mutation in the gene coding choline acetyltransferase
Specification of motoneurons from human embryonic stem cells.
Zhang et al., In Nat Biotechnol, 2005
The in vitro-generated motoneurons expressed HB9, HoxC8, choline acetyltransferase and vesicular acetylcholine transporter, induced clustering of acetylcholine receptors in myotubes, and were electrophysiologically active.
Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord.
Goldman et al., New York City, United States. In Nat Biotechnol, 2004
These included both chx10(+) interneurons and Islet1(+)/Hb9(+)/ChAT(+) motor neurons; the latter were recognized by green fluorescent protein (GFP) driven by the Hb9 enhancer.
Smooth muscle cholinergic denervation hypersensitivity in diverticular disease.
Williams et al., London, United Kingdom. In Lancet, 2003
METHODS: Two investigators independently did a blinded immunohistochemical image analysis of localising antibodies to choline acetyltransferase, co-localised with protein gene product (PGP)--a marker of general neural tissue-and smooth muscle muscarinic M3 receptors, on three histological sections of sigmoid colons from ten patients with diverticular disease and ten controls, after resections for rectal tumours.
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