Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in
In Molecular Therapy. Nucleic Acids, 2001
... For murine LDLR, SREBP2, SR-BI, LIPC, HMGCS2, CYP7A1, ABCA1, and ACAT1, TaqMan Gene Expression Assays were used; assay IDs: Mm00440169_m1, Mm01306297_g1, Mm00450236_m1, Mm01147313_m1, Mm00550050_m1, ...
Fibrates and cholestasis.
New Haven, United States. In Hepatology, Aug 2015
One of these NRs is peroxisome proliferator-activated receptor alpha (PPARα), which plays a central role in maintaining cholesterol, lipid, and bile acid homeostasis by regulating genes responsible for bile acid synthesis and transport in humans, including cytochrome P450 (CYP) isoform 7A1 (CYP7A1), CYP27A1, CYP8B1, uridine 5'-diphospho-glucuronosyltransferase 1A1, 1A3, 1A4, 1A6, hydroxysteroid sulfotransferase enzyme 2A1, multidrug resistance protein 3, and apical sodium-dependent bile salt transporter.
Bile acids as metabolic regulators.
Kansas City, United States. In Curr Opin Gastroenterol, Mar 2015
Two studies identified intestine Diet1 and hepatic SHP-2 as novel regulators of CYP7A1 and bile acid synthesis through the gut-liver FXR-fibroblast growth factor 15/19-FGF receptor four signaling axis.