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Cytochrome P450, family 7, subfamily A, polypeptide 1

Cholesterol 7-alpha-Hydroxylase, CYP7A1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010] (from NCBI)
Top mentioned proteins: ACID, HAD, beta 2-adrenoceptor, V1a, CAN
Papers using Cholesterol 7-alpha-Hydroxylase antibodies
Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in C57BL/6J mice
Supplier
Obika Satoshi et al., In Molecular Therapy. Nucleic Acids, 2001
... For murine LDLR, SREBP2, SR-BI, LIPC, HMGCS2, CYP7A1, ABCA1, and ACAT1, TaqMan Gene Expression Assays were used; assay IDs: Mm00440169_m1, Mm01306297_g1, Mm00450236_m1, Mm01147313_m1, Mm00550050_m1, ...
Papers on Cholesterol 7-alpha-Hydroxylase
Bile Acid Signaling Is Involved in the Neurological Decline in a Murine Model of Acute Liver Failure.
New
DeMorrow et al., Temple, United States. In Am J Pathol, Feb 2016
C57Bl/6 or cytochrome p450 7A1 knockout (Cyp7A1(-/-)) mice were fed a control, cholestyramine-containing, or bile acid-containing diet before azoxymethane (AOM)-induced acute liver failure.
Taurine ameliorates cholesterol metabolism by stimulating bile acid production in high cholesterol-fed rats.
New
Fukuda et al., Fukui, Japan. In Clin Exp Pharmacol Physiol, Jan 2016
In the liver, taurine supplementation increased the mRNA expression and enzymatic activity of hepatic cholesterol 7α-hydroxylase (CYP7A1), the rate-limiting enzyme for bile acid synthesis, by tree- and two-fold, respectively.
Hepatocyte differentiation of human induced pluripotent stem cells is modulated by stearoyl-CoA desaturase 1 activity.
New
Darabi et al., Tabrīz, Iran. In Dev Growth Differ, Dec 2015
Liver-specific markers, specifically α-fetoprotein, albumin and urea in conditioned medium, and hepatocyte nuclear factor 4α (HNF4α) and cytochrome P450 7A1 (CYP7A1) gene expressions and triglyceride in cellular extracts were analyzed at various development stages.
Fibrates and cholestasis.
Review
New
Boyer et al., New Haven, United States. In Hepatology, Aug 2015
One of these NRs is peroxisome proliferator-activated receptor alpha (PPARα), which plays a central role in maintaining cholesterol, lipid, and bile acid homeostasis by regulating genes responsible for bile acid synthesis and transport in humans, including cytochrome P450 (CYP) isoform 7A1 (CYP7A1), CYP27A1, CYP8B1, uridine 5'-diphospho-glucuronosyltransferase 1A1, 1A3, 1A4, 1A6, hydroxysteroid sulfotransferase enzyme 2A1, multidrug resistance protein 3, and apical sodium-dependent bile salt transporter.
Central GLP-1 receptor activation improves cholesterol metabolism partially independent of its effect on food intake.
New
Jain et al., Ahmadābād, India. In Can J Physiol Pharmacol, Aug 2015
Expression of SREBP-1c was reduced while that of LDLR and CYP7A1 was increased after the repeated dose treatment, and there was no change in HMG CoA reductase.
Inter-individual Variability in Response to Plant Sterol and Stanol Consumption.
Review
New
Jones, Winnipeg, Canada. In J Aoac Int, May 2015
Particularly, single nucleotide polymorphisms within the genes coding for CYP7A1 and ApoE, as well as possibly other genes including ABCG5 and ABCG8, exist as predictors of whether LDL-C levels will decrease or even increase subsequent to plant sterol administration.
Bile acids as metabolic regulators.
Review
New
Chiang et al., Kansas City, United States. In Curr Opin Gastroenterol, Mar 2015
Two studies identified intestine Diet1 and hepatic SHP-2 as novel regulators of CYP7A1 and bile acid synthesis through the gut-liver FXR-fibroblast growth factor 15/19-FGF receptor four signaling axis.
Recent advances in the development of farnesoid X receptor agonists.
Review
Lindor et al., Scottsdale, United States. In Ann Transl Med, 2015
FXRs regulate the expression of the gene encoding for cholesterol 7 alpha-hydroxylase, which is the rate-limiting enzyme in BA synthesis.
Hypocholesterolemic Effects of the Cauliflower Culinary-Medicinal Mushroom, Sparassis crispa (Higher Basidiomycetes), in Diet-Induced Hypercholesterolemic Rats.
Suh et al., Seoul, South Korea. In Int J Med Mushrooms, 2014
SCE supplementation significantly enhanced hepatic cholesterol catabolism through the upregulation of cholesterol 7α-hydroxylase (CYP7A1) messenger RNA (mRNA) expression (2.55-fold compared with that in the NC group; P < 0.05) and the downregulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA expression (0.57-fold compared with that in the NC group; P < 0.05).
Regulation of Cholesterol Metabolism in Liver: Link to NAFLD and Impact of n-3 PUFAs.
Review
Cha et al., Inch'ŏn, South Korea. In J Lifestyle Med, 2013
The increased n-3 PUFAs in fat-1 transgenic mice reduced diet-induced hyperlipidemia and fatty liver through induction of CYP7A1 expression and activation of cholesterol catabolism to bile acid.
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist.
Impact
Bäckhed et al., Göteborg, Sweden. In Cell Metab, 2013
Rederivation of Fxr-deficient mice as GF demonstrated that the gut microbiota regulated expression of fibroblast growth factor 15 in the ileum and cholesterol 7α-hydroxylase (CYP7A1) in the liver by FXR-dependent mechanisms.
Fibroblast growth factor 7 inhibits cholesterol 7α-hydroxylase gene expression in hepatocytes.
GeneRIF
Zhang et al., Shanghai, China. In Biochem Biophys Res Commun, 2012
these data suggest that FGF7 is a novel regulator of CYP7A1 expression in hepatocytes and may prevent hepatocytes from accumulating toxic bile acids during liver injury and fibrosis.
Peroxisome Proliferator-activated receptor γ activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression.
GeneRIF
Han et al., China. In J Biol Chem, 2012
Results indicate that although PPARgamma activation increased PCSK9 expression, PPARgamma activation induced LDLR and CYP7A1 expression that enhanced LDL cholesterol metabolism.
Cyanidin-3-O-β-glucoside upregulates hepatic cholesterol 7α-hydroxylase expression and reduces hypercholesterolemia in mice.
GeneRIF
Ling et al., Guangzhou, China. In Mol Nutr Food Res, 2012
Cyanidin-3-O-beta-glucoside consumption reduced hypercholesterolemia, promoted fecal bile acid excretion and upregulated hepatic cholesterol 7a-hydroxylase expression (CYP7A1).
Chitosan oligosaccharides promote reverse cholesterol transport and expression of scavenger receptor BI and CYP7A1 in mice.
GeneRIF
Qin et al., Taishan, China. In Exp Biol Med (maywood), 2012
Chitosan oligosaccharides promote reverse cholesterol transport and expression of scavenger receptor BI and CYP7A1 in mice
[Mechanisms of bile acid biosynthesis regulation--autoregulation by bile acids].
Review
GeneRIF
Hebanowska, Gdańsk, Poland. In Postepy Biochem, 2010
The main enzyme regulating bile acids biosynthesis is CYP7A1 (7alpha-cholesterol hydroxylase). [review]
Biological, clinical and population relevance of 95 loci for blood lipids.
Impact
Kathiresan et al., Ann Arbor, United States. In Nature, 2010
The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism.
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
Impact
Kliewer et al., Dallas, United States. In Cell Metab, 2005
Here, we demonstrate that fibroblast growth factor 15 (FGF15) signals from intestine to liver to repress the gene encoding cholesterol 7alpha-hydroxylase (CYP7A1), which catalyzes the first and rate-limiting step in the classical bile acid synthetic pathway.
Bile acid regulation of gene expression: roles of nuclear hormone receptors.
Review
Impact
Chiang, United States. In Endocr Rev, 2002
Bile acids activate the farnesoid X receptor (FXR) to inhibit transcription of the gene for cholesterol 7alpha-hydroxylase, and stimulate excretion and transport of bile acids.
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.
Impact
Gonzalez et al., Bethesda, United States. In Cell, 2000
Bile acid repression and induction of cholesterol 7alpha-hydroxylase and the ileal bile acid binding protein, respectively, did not occur in FXR/BAR null mice, establishing the regulatory role of FXR/BAR for the expression of these genes in vivo.
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