Genetic determination of irritable bowel syndrome.
Cluj-Napoca / Kolozsvár, Romania. In World J Gastroenterol, 2008
Whereas no specific gene has been identified in association with IBS, recent studies have noticed the importance of polymorphisms in the promoter region of the serotonin reuptake transporter gene, G-protein beta 3 subunit gene (C825T), cholecystokinin receptor (CCKAR gene 779T>C), and high-producer tumor necrosis factor genotype.
Structural basis of cholecystokinin receptor binding and regulation.
Scottsdale, United States. In Pharmacol Ther, 2008
Two structurally-related guanine nucleotide-binding protein-coupled receptors for two related peptides, cholecystokinin (CCK) and gastrin, have evolved to exhibit substantial diversity in specificity of ligand recognition, in their molecular basis of binding these ligands, and in their mechanisms of biochemical and cellular regulation.