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CHODL, chondrolectin, C21orf68, PRED12
This gene encodes a type I membrane protein with a carbohydrate recognition domain characteristic of C-type lectins in its extracellular portion. In other proteins, this domain is involved in endocytosis of glycoproteins and exogenous sugar-bearing pathogens. This protein localizes predominantly to the perinuclear region. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] (from NCBI)
Papers on CHODL
Chondrolectin is a novel diagnostic biomarker and a therapeutic target for lung cancer.
Daigo et al., Tokyo, Japan. In Clin Cancer Res, 2012
Data indicate that chondrolectin (CHODL) is likely to be a prognostic biomarker in the clinic and targeting CHODL might be a strategy for the development of anticancer drugs.
Expression and localization of CHODLDeltaE/CHODLfDeltaE, the soluble isoform of chondrolectin.
Merregaert et al., Edegem, Belgium. In Cell Biol Int, 2007
CHODLDeltaE/CHODLfDeltaE protein variant localizes in the late endoplasmic reticulum and is detected in spleen and tonsils; the isoform seems to be differentially expressed in thymocytes and lymphocytes.
A novel alternative spliced chondrolectin isoform lacking the transmembrane domain is expressed during T cell maturation.
Merregaert et al., Edegem, Belgium. In J Biol Chem, 2003
study describes the molecular characterization of novel members of the chondrolectin family associated with T cell maturation and a subcellular localization of chondrolectin f isoform in the endoplasmic reticulum-Golgi apparatus
Molecular cloning and characterization of human chondrolectin, a novel type I transmembrane protein homologous to C-type lectins.
Merregaert et al., Antwerp, Belgium. In Genomics, 2002
cloning and characterization; localized at chromosome 21q21
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