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CHO1 Cho1p

CHO1, phosphatidylserine synthase, CDPdiacylglycerol-Serine O-Phosphatidyltransferase, MKLP1
The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in two transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PI3K, CAN, ACID, V1a, HAD
Papers on CHO1
Lipid Biosynthetic Genes Affect Candida albicans Extracellular Vesicle Morphology, Cargo, and Immunostimulatory Properties.
New
Casadevall et al., New York City, United States. In Eukaryot Cell, Aug 2015
The genes encoding phosphatidylserine synthase (CHO1) and phosphatidylserine decarboxylase (PSD1 and PSD2) are Candida albicans genes involved in phospholipid biosynthesis, and mutations in these genes affect mitochondrial function, cell wall thickness, and virulence in mice.
WD repeat-containing protein 5 (WDR5) localizes to the midbody and regulates abscission.
New
Ma et al., Santa Barbara, United States. In J Biol Chem, May 2015
Here, we report that WD repeat-containing protein 5 (WDR5), a core subunit of COMPASS/MLL family histone H3 lysine 4 methyltransferase (H3K4MT) complexes, resides at the midbody and associates with a subset of midbody regulatory proteins, including PRC1 and CYK4/MKLP1.
CYK4 promotes antiparallel microtubule bundling by optimizing MKLP1 neck conformation.
New
Mishima et al., Cambridge, United Kingdom. In Plos Biol, Apr 2015
Centralspindlin, a constitutive 2:2 heterotetramer of MKLP1 (a kinesin-6) and the non-motor subunit CYK4, plays important roles in cytokinesis.
Phosphorylation of CHO1 by Lats1/2 regulates the centrosomal activation of LIMK1 during cytokinesis.
Nojima et al., Suita, Japan. In Cell Cycle, 2014
As components of the centralspindlin complex, the kinesin-like protein CHO1 and its splicing variant MKLP1 colocalize with chromosome passenger proteins and GTPases and regulate the formation of the contractile ring and cytokinesis; however, the regulatory mechanisms of CHO1/MKLP1 remain elusive.
The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis.
Glotzer et al., Chicago, United States. In Elife, 2014
Centralspindlin, composed of the Rho family GTPase-activating protein (RhoGAP) MgcRacGAP/CYK-4 and the kinesin MKLP1/ZEN-4, is known to activate ECT-2, but the underlying mechanism is not understood.
Phosphatidylserine in the brain: metabolism and function.
Review
Spector et al., Bethesda, United States. In Prog Lipid Res, 2014
PS is synthesized from phosphatidylcholine or phosphatidylethanolamine by exchanging the base head group with serine, and this reaction is catalyzed by phosphatidylserine synthase 1 and phosphatidylserine synthase 2 located in the endoplasmic reticulum.
Gain-of-function mutations in the phosphatidylserine synthase 1 (PTDSS1) gene cause Lenz-Majewski syndrome.
Impact
Moore et al., London, United Kingdom. In Nat Genet, 2014
By using whole-exome sequencing and selecting variants consistent with the predicted dominant de novo etiology of LMS, we identified causative heterozygous missense mutations in PTDSS1, which encodes phosphatidylserine synthase 1 (PSS1).
Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis.
GeneRIF
Nakayama et al., Ibaraki, Japan. In Embo J, 2012
It was shown that, during cytokinesis, Arf6 is first accumulated around the cleavage furrow and, prior to abscission, recruited onto the Flemming body via interaction with MKLP1.
Downregulation of KIF23 suppresses glioma proliferation.
GeneRIF
Toda et al., Tokyo, Japan. In J Neurooncol, 2012
The results of this study indicated that downregulation of KIF23 decreases proliferation of glioma cells and that KIF23 may be a novel therapeutic target in malignant glioma.
Phosphatidylserine is polarized and required for proper Cdc42 localization and for development of cell polarity.
Impact
Grinstein et al., Toronto, Canada. In Nat Cell Biol, 2011
Mutants lacking phosphatidylserine synthase had impaired polarization of the Cdc42 complex, leading to a delay in bud emergence, and defective mating.
Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation.
GeneRIF
Bejsovec et al., Durham, United States. In J Cell Sci, 2010
Results identify two modulators of the Wnt pathway, Tum and Pav, that have shared functions in cell division, which hints at a possible link between cytokinesis and Wnt activity during tumorigenesis.
Arabidopsis EMBRYOMAKER encoding an AP2 domain transcription factor plays a key role in developmental change from vegetative to embryonic phase.
GeneRIF
Takahata et al., Morioka, Japan. In Plant Mol Biol, 2010
AtEMK is a key player to maintain embryonic identity, and the rapid disappearance of AtEMK expression during germination is essential for the developmental transition between the embryonic and vegetative phases in plants. [AtEMK]
Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis.
GeneRIF
Mishima et al., Cambridge, United Kingdom. In Curr Biol, 2010
Study shows that 14-3-3 protein binds centralspindlin when the kinesin-6 component MKLP1 is phosphorylated at S710; 14-3-3 prevents centralspindlin from clustering in vitro, and MKLP1 mutant that is unable to bind 14-3-3 forms aberrant clusters in vivo.
Cytokinesis and cancer: Polo loves ROCK'n' Rho(A).
Review
Xu et al., Beijing, China. In J Genet Genomics, 2010
More specifically, Plk1 phosphorylates the centralspindlin complex Cyk4 and MKLP1/CHO1, thus recruiting RhoA guanine nucleotide-exchange factor (GEF) Ect2 through its phosphopeptide-binding BRCT domains.
The molecular basis of organ formation: insights from the C. elegans foregut.
Review
Mango, Cambridge, United States. In Annu Rev Cell Dev Biol, 2008
During morphogenesis, the pharyngeal precursors form an epithelial tube in a process that is independent of cadherins, catenins, and integrins but requires the kinesin zen-4/MKLP1.
Regulation of phospholipid synthesis in Saccharomyces cerevisiae by zinc depletion.
Review
Han et al., New Brunswick, United States. In Biochim Biophys Acta, 2007
Alterations in phosphatidylinositol and phosphatidylethanolamine can be ascribed to an increase in PIS1-encoded phosphatidylinositol synthase activity and to decreases in the activities of CDP-diacylglycerol pathway enzymes including the CHO1-encoded phosphatidylserine synthase, respectively.
The C. elegans pharynx: a model for organogenesis.
Review
Mango, Salt Lake City, United States. In Wormbook, 2006
Rather, the kinesin ZEN-4/MKLP1 and CYK-4/RhoGAP are critical to establish the apical domain during epithelial polarization.
Cell cycle regulation of central spindle assembly.
Impact
Glotzer et al., Vienna, Austria. In Nature, 2004
Central spindle assembly requires the centralspindlin complex composed of the Caenorhabditis elegans ZEN-4 (mammalian orthologue MKLP1) kinesin-like protein and the Rho family GAP CYK-4 (MgcRacGAP).
A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles.
Impact
McIntosh et al., Boulder, United States. In Nature, 1992
The protein was originally identified as a spindle antigen by the CHO1 monoclonal antibody and shown to be required for mitotic progression.
Molecular genetics of membrane phospholipid synthesis.
Review
Impact
Raetz, In Annu Rev Genet, 1985
Why does overproduction of phosphatidylserine synthase have no effect on phospholipid composition?
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