Immunoconjugates in the management of hairy cell leukemia.
Bethesda, United States. In Best Pract Res Clin Haematol, Dec 2015
An affinity matured version of BL22, termed moxetumomab pasudotox (formerly HA22 or CAT-8015) achieved high CR rates in phase I, and is currently undergoing multicenter Phase 3 testing.
Physiological Roles of Hydrogen Sulfide and Polysulfides.
Kodaira, Japan. In Handb Exp Pharmacol, 2014
H2S is produced from L-cysteine by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) together with cysteine aminotransferase (CAT).
Antioxidant Potential of Plumieride against CCl₄-Induced Peroxidative Damage in Rats.
Jaipur, India. In Antioxidants (basel), 2013
The antioxidant potential was evaluated by using hepatic tissue for SOD (superoxide dismutase), CAT (catalase), GSH (reduced glutathione), GPx (glutathione peroxidase), GR (glutathione reductase) and LPO (lipid peroxidation) alongwith the concomitant blood serum for AST & ALT (aspartate and alanine transaminases), GGT (gamma glutamyl transpeptidase), ALP (alkaline phosphatase), total bilirubin and total protein contents.
Challenges with advanced therapy medicinal products and how to meet them.
In Nat Rev Drug Discov, 2010
Central to this framework is the Committee for Advanced Therapies (CAT) at the European Medicines Agency (EMA), comprising a multidisciplinary scientific expert committee, representing all EU member states and European Free Trade Association countries, as well as patient and medical associations.
Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer.
Cambridge, United Kingdom. In J Clin Oncol, 2007
PATIENTS AND METHODS: We examined associations between 54 polymorphisms that tag the known common variants (minor allele frequency > 0.05) in 10 genes involved in oxidative damage repair (CAT, SOD1, SOD2, GPX1, GPX4, GSR, TXN, TXN2, TXNRD1, and TXNRD2) and survival in 4,470 women with breast cancer.