The comet assay: a method to measure DNA damage in individual cellsmore suppliers
In Cell Death & Disease, 2005
... antibody (Abcam, Cambridge, MA, USA), p-Chk1 (Ser 345), Chk1 (Cell Signaling Technology, Inc., Beverly, MA, ...
CHK2 stability is regulated by the E3 ubiquitin ligase SIAH2.
Córdoba, Spain. In Oncogene, Feb 2016
UNASSIGNED: The serine threonine checkpoint kinase 2 (CHK2) is a critical protein involved in the DNA damage-response pathway, which is activated by phosphorylation inducing cellular response such as DNA repair, cell-cycle regulation or apoptosis.
DNA damage in cancer therapeutics: a boon or a curse?
Sydney, Australia. In Cancer Res, Jul 2015
The tumor-suppressive role of DDR activity during the premalignant stage has been studied, and strong evidence is emerging for an oncogenic role for DDR proteins such as DNA-PK and CHK1 during the later stages of tumor development.
Hsp90: A New Player in DNA Repair?
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Roma, Italy. In Biomolecules, 2014
Multiple components of the DNA double strand breaks repair machinery, including BRCA1, BRCA2, CHK1, DNA-PKcs, FANCA, and the MRE11/RAD50/NBN complex, have been described to be client proteins of Hsp90, which acts as a regulator of the diverse DDR pathways.