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Chitinase 1

Chitinase, chitotriosidase
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, YKL-40, fibrillin-1
Papers using Chitinase antibodies
Description, distribution, activity and phylogenetic relationship of ribosome-inactivating proteins in plants, fungi and bacteria
Shaw Pang-Chui et al., In Nucleic Acids Research, 2003
... Co-expression of a modified maize ribosome-inactivating protein and a rice basic chitinase gene in transgenic rice plants confers enhanced ...
Papers on Chitinase
Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study.
Girkontaitė et al., Vilnius, Lithuania. In Int Arch Allergy Immunol, Feb 2016
RESULTS: Serum levels of adiponectin, chemokine (C-C motif) ligand 5 (CCL5), C-reactive protein (CRP), chitinase 3-like 1 (CHI3L1), complement factor D (CFD), endoglin, lipocalin-2, osteopontin, retinol-binding protein 4 (RBP4), and platelet factor 4 (PF4) were significantly higher, whereas levels of trefoil factor 3 (TFF3) were significantly lower, in ACD patients than in healthy controls.
YKL-40/chitinase-3-like protein 1 is associated with poor prognosis and promotes cell growth and migration of cholangiocarcinoma.
Talabnin et al., Nakhon Ratchasima, Thailand. In Tumour Biol, Feb 2016
UNASSIGNED: YKL-40, a chitinase-like glycoprotein, is expressed at a high level in cancer patients.
YKL-40 as marker of severe lung disease in cystic fibrosis patients.
Salpietro et al., Catania, Italy. In J Cyst Fibros, Feb 2016
BACKGROUND: YKL-40 is a chitinase-like protein present in serum of healthy subjects and its levels are increased in several human inflammatory diseases.
Chitinases and immunity: Ancestral molecules with new functions.
Malaguarnera et al., Catania, Italy. In Immunobiology, Jan 2016
In humans, despite the absence of endogenous chitin, a number of Chitinases and Chitinase-like Proteins (C/CLPs) have been identified.
Adaptations of the Secretome of Candida albicans in Response to Host-Related Environmental Conditions.
Brul et al., Amsterdam, Netherlands. In Eukaryot Cell, Dec 2015
The genes ENG1, CHT3, and SCW11, which encode an endoglucanase, the major chitinase, and a β-1,3-glucan-modifying enzyme, respectively, are periodically expressed and peak in M/G1.
Fungal chitinases: function, regulation, and potential roles in plant/pathogen interactions.
Göhre et al., Düsseldorf, Germany. In Curr Genet, Dec 2015
Although chitinase research made huge progress in the last decades, our knowledge about their role in phytopathogenic fungi is still scarce.
Spectrum of allergens for Japanese cedar pollinosis and impact of component-resolved diagnosis on allergen-specific immunotherapy.
Kawamoto et al., Japan. In Allergol Int, Oct 2015
Allergenome analysis identified a chitinase, a lipid transfer protein, a serine protease, and an aspartic protease as novel IgE-reactive allergens in patients with JCP allergy.
Identification of a Novel Small Cysteine-Rich Protein in the Fraction from the Biocontrol Fusarium oxysporum Strain CS-20 that Mitigates Fusarium Wilt Symptoms and Triggers Defense Responses in Tomato.
Zavriev et al., Moscow, Russia. In Front Plant Sci, 2014
This fraction initiated an ion exchange response in cultured tomato cells resulting in a reversible alteration of extracellular pH; increased tomato chitinase activity, and induced systemic resistance by enhancing PR-1 expression in tomato leaves.
Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage.
Allen et al., Gaithersburg, United States. In Nat Immunol, 2014
Enzymatically inactive chitinase-like proteins (CLPs) such as BRP-39, Ym1 and Ym2 are established markers of immune activation and pathology, yet their functions are essentially unknown.
Chitinases from Bacteria to Human: Properties, Applications, and Future Perspectives.
Gupta et al., New Delhi, India. In Enzyme Res, 2014
Designing of chitinase by applying directed laboratory evolution and rational approaches for improved catalytic activity for cost-effective field applications has also been explored.
Differences in the roles of the two surface-exposed tyrosine residues, Y240 and Y481, of Serratia marcescens chitinase B during processive degradation of crystalline chitin.
Watanabe et al., Niigata, Japan. In J Gen Appl Microbiol, 2014
Chitinase B from Serratia marcescens 2170 is one of the processive chitinases, and it has a linear path of aromatic amino acid residues on the surface and in the catalytic cleft.
Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation.
Artis et al., Philadelphia, United States. In Science, 2014
Notably, helminth-induced impairment of antiviral immunity was evident in germ-free mice, but neutralization of Ym1, a chitinase-like molecule that is associated with alternatively activated macrophages, could partially restore antiviral immunity.
Chitinase 1 is a biomarker for and therapeutic target in scleroderma-associated interstitial lung disease that augments TGF-β1 signaling.
Elias et al., New Haven, United States. In J Immunol, 2012
Patients with systemic sclerosis and interstitial lung disease show high levels of circulating Chit1 activity that correlate with disease severity.
Genetic association between human chitinases and lung function in COPD.
Sandford et al., Vancouver, Canada. In Hum Genet, 2012
study demonstrated genetic associations between chitinase gene variants and lung function level and rate of decline in chronic obstructive pulmonary disease patients from the Lung Health Study
Chitotriosidase, interleukin-1 beta and tumor necrosis factor alpha levels in mild preeclampsia.
Baser et al., Ankara, Turkey. In Arch Gynecol Obstet, 2012
Serum Chitotriosidase activity was significantly higher in the preeclampsia group as compared with levels in the control group.
Inflammatory marker levels in obese adolescents with glucose intolerance: increased chitotriosidase activity.
Ersoy et al., İzmir, Turkey. In Clin Biochem, 2012
Data suggest that serum chitotriosidase activity (a possible marker of inflammatory processes) is increased in obese adolescents with impaired glucose tolerance.
Human chitotriosidase-catalyzed hydrolysis of chitosan.
Sørlie et al., Norway. In Biochemistry, 2012
Human chitotriosidase degrades chitosan primarily via an endoprocessive mechanism: the main hydrolysis product is chitobiose, (i.e., the acetylated dimer) fully consistent with its role as a "normal" processive enzyme.
In situ click chemistry: probing the binding landscapes of biological molecules.
Finn et al., Los Angeles, United States. In Chem Soc Rev, 2010
Examples of the discovery of potent inhibitors of acetylcholinesterases, carbonic anhydrase, HIV-protease, and chitinase are described, as are methods for the templated assembly of agents that bind DNA and proteins.
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
Chupp et al., Chicago, United States. In N Engl J Med, 2008
RESULTS: A promoter SNP (-131C-->G) in CHI3L1, the chitinase 3-like 1 gene encoding YKL-40, was associated with elevated serum YKL-40 levels (P=1.1 x 10(-13)), asthma (P=0.047),
A chitinase-like protein in the lung and circulation of patients with severe asthma.
Elias et al., New Haven, United States. In N Engl J Med, 2007
The related chitinase-like protein, YKL-40 (also called human cartilage glycoprotein 39 [HCgp-39] and chitinase 3-like 1), can be readily measured in the serum.
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